Terpolymer-chitosan membranes as biomaterial

Autores
Bravi Costantino, Maria Leticia; Belluzo, María Soledad; Oberti, Tamara Gisela; Cortizo, Ana María; Cortizo, María Susana
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present study shows a novel copolymer synthesis, its application in the membrane design and the physicochemical and biological characterization of the biomaterial obtained. Terpolymer starting diisopropyl fumarate (F), vinyl benzoate (V) and 2-hydroxyethyl methacrylate (H) was prepared by thermal radical polymerization. This polymer (FVH) was obtained in several monomer ratios and characterized by spectroscopic and chromatographic methods (FTIR, ¹H-NMR and SEC). The best relationship of F:V:H was 5:4:1, which allows efficient interaction with chitosan through cross-linking with borax to achieve scaffolds for potential biomedical applications. The membranes were obtained by solvent casting and analyzed by scanning electron microscopy (SEM), swelling behavior and mechanical properties. In addition, we studied the possible cytotoxicity and biocompatibility of these materials using a murine macrophage-like cell line (RAW 264.7) and bone marrow mesenchymal progenitor cells (BMPC), respectively, taking into account their intended applications. The results of this study show that the terpolymer obtained and its combination with a natural polymer is a very interesting strategy to obtain a biomaterial with possible applications in regenerative medicine and this could be extended to other structurally related systems.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Laboratorio de Investigación en Osteopatías y Metabolismo Mineral
Materia
Química
Biología
biomaterials
chitosan
cytotoxicity
fumaric polymers
swelling
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/164070
Acceder
id SEDICI_02382aafe897397f5621affbbd7d15de
oai_identifier_str oai:sedici.unlp.edu.ar:10915/164070
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Terpolymer-chitosan membranes as biomaterialBravi Costantino, Maria LeticiaBelluzo, María SoledadOberti, Tamara GiselaCortizo, Ana MaríaCortizo, María SusanaQuímicaBiologíabiomaterialschitosancytotoxicityfumaric polymersswellingThe present study shows a novel copolymer synthesis, its application in the membrane design and the physicochemical and biological characterization of the biomaterial obtained. Terpolymer starting diisopropyl fumarate (F), vinyl benzoate (V) and 2-hydroxyethyl methacrylate (H) was prepared by thermal radical polymerization. This polymer (FVH) was obtained in several monomer ratios and characterized by spectroscopic and chromatographic methods (FTIR, ¹H-NMR and SEC). The best relationship of F:V:H was 5:4:1, which allows efficient interaction with chitosan through cross-linking with borax to achieve scaffolds for potential biomedical applications. The membranes were obtained by solvent casting and analyzed by scanning electron microscopy (SEM), swelling behavior and mechanical properties. In addition, we studied the possible cytotoxicity and biocompatibility of these materials using a murine macrophage-like cell line (RAW 264.7) and bone marrow mesenchymal progenitor cells (BMPC), respectively, taking into account their intended applications. The results of this study show that the terpolymer obtained and its combination with a natural polymer is a very interesting strategy to obtain a biomaterial with possible applications in regenerative medicine and this could be extended to other structurally related systems.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasLaboratorio de Investigación en Osteopatías y Metabolismo Mineral2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf383-393http://sedici.unlp.edu.ar/handle/10915/164070enginfo:eu-repo/semantics/altIdentifier/issn/1549-3296info:eu-repo/semantics/altIdentifier/issn/1552-4965info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.37295info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:24:06Zoai:sedici.unlp.edu.ar:10915/164070Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:24:06.681SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Terpolymer-chitosan membranes as biomaterial
title Terpolymer-chitosan membranes as biomaterial
spellingShingle Terpolymer-chitosan membranes as biomaterial
Bravi Costantino, Maria Leticia
Química
Biología
biomaterials
chitosan
cytotoxicity
fumaric polymers
swelling
title_short Terpolymer-chitosan membranes as biomaterial
title_full Terpolymer-chitosan membranes as biomaterial
title_fullStr Terpolymer-chitosan membranes as biomaterial
title_full_unstemmed Terpolymer-chitosan membranes as biomaterial
title_sort Terpolymer-chitosan membranes as biomaterial
dc.creator.none.fl_str_mv Bravi Costantino, Maria Leticia
Belluzo, María Soledad
Oberti, Tamara Gisela
Cortizo, Ana María
Cortizo, María Susana
author Bravi Costantino, Maria Leticia
author_facet Bravi Costantino, Maria Leticia
Belluzo, María Soledad
Oberti, Tamara Gisela
Cortizo, Ana María
Cortizo, María Susana
author_role author
author2 Belluzo, María Soledad
Oberti, Tamara Gisela
Cortizo, Ana María
Cortizo, María Susana
author2_role author
author
author
author
dc.subject.none.fl_str_mv Química
Biología
biomaterials
chitosan
cytotoxicity
fumaric polymers
swelling
topic Química
Biología
biomaterials
chitosan
cytotoxicity
fumaric polymers
swelling
dc.description.none.fl_txt_mv The present study shows a novel copolymer synthesis, its application in the membrane design and the physicochemical and biological characterization of the biomaterial obtained. Terpolymer starting diisopropyl fumarate (F), vinyl benzoate (V) and 2-hydroxyethyl methacrylate (H) was prepared by thermal radical polymerization. This polymer (FVH) was obtained in several monomer ratios and characterized by spectroscopic and chromatographic methods (FTIR, ¹H-NMR and SEC). The best relationship of F:V:H was 5:4:1, which allows efficient interaction with chitosan through cross-linking with borax to achieve scaffolds for potential biomedical applications. The membranes were obtained by solvent casting and analyzed by scanning electron microscopy (SEM), swelling behavior and mechanical properties. In addition, we studied the possible cytotoxicity and biocompatibility of these materials using a murine macrophage-like cell line (RAW 264.7) and bone marrow mesenchymal progenitor cells (BMPC), respectively, taking into account their intended applications. The results of this study show that the terpolymer obtained and its combination with a natural polymer is a very interesting strategy to obtain a biomaterial with possible applications in regenerative medicine and this could be extended to other structurally related systems.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Laboratorio de Investigación en Osteopatías y Metabolismo Mineral
description The present study shows a novel copolymer synthesis, its application in the membrane design and the physicochemical and biological characterization of the biomaterial obtained. Terpolymer starting diisopropyl fumarate (F), vinyl benzoate (V) and 2-hydroxyethyl methacrylate (H) was prepared by thermal radical polymerization. This polymer (FVH) was obtained in several monomer ratios and characterized by spectroscopic and chromatographic methods (FTIR, ¹H-NMR and SEC). The best relationship of F:V:H was 5:4:1, which allows efficient interaction with chitosan through cross-linking with borax to achieve scaffolds for potential biomedical applications. The membranes were obtained by solvent casting and analyzed by scanning electron microscopy (SEM), swelling behavior and mechanical properties. In addition, we studied the possible cytotoxicity and biocompatibility of these materials using a murine macrophage-like cell line (RAW 264.7) and bone marrow mesenchymal progenitor cells (BMPC), respectively, taking into account their intended applications. The results of this study show that the terpolymer obtained and its combination with a natural polymer is a very interesting strategy to obtain a biomaterial with possible applications in regenerative medicine and this could be extended to other structurally related systems.
publishDate 2022
dc.date.none.fl_str_mv 2022-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/164070
url http://sedici.unlp.edu.ar/handle/10915/164070
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1549-3296
info:eu-repo/semantics/altIdentifier/issn/1552-4965
info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.37295
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
383-393
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.982451

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