Synthesis and Properties of Dendronized Chitosan

Autores
Aldana, Ana Agustina; Martinelli, Marisa; Strumia, Miriam Cristina
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chitosan films and microspheres were prepared and their surfaces were functionalized with first generation dendritic molecules. The films were modified by Weisocyanate dendron, while Behera?s and bis Behera?s amine dendrons were used to modify the microspheres. Prior to dendronization films were prepared by blending chitosan with 18% of polyvinyl pyrrolidone (PVP), and casting the resulting mixture. The degree of dendronization reached was 28%. The microspheres were prepared by coacervation/precipitation, after which the surfaces were activated with either epychlorohydrine (ECH) or 1,4-butanediol diglycidyl ether (BDGE). The oxirane groups were utilized to form covalent bonds between chitosan and dendrons. The degree of dendronization yielded with Behera?s amine was 60% for both activating agents. When bis Behera?s amine was used, the dendronization reached values of 15 and 21% when ECH or BDGE were used, respectively. The dendronized products were characterized through spectroscopic and microscopic studies and by determination of swelling indexes. Only one of the surfaces was dendronized in every film, which therefore presented a hydrophobic and a hydrophilic surface. Since these films maintain the properties of chitosan, they offer interesting potential as dressings for exuding wounds. The different surfaces make the microspheres potentially applicable as carriers for delivery and controlled release of drugs.
Fil: Aldana, Ana Agustina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Fil: Martinelli, Marisa. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Materia
Biomaterials
Dendronization
Dendronized Chitosan
Functional Polymers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14731
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/14731
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synthesis and Properties of Dendronized ChitosanAldana, Ana AgustinaMartinelli, MarisaStrumia, Miriam CristinaBiomaterialsDendronizationDendronized ChitosanFunctional Polymershttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Chitosan films and microspheres were prepared and their surfaces were functionalized with first generation dendritic molecules. The films were modified by Weisocyanate dendron, while Behera?s and bis Behera?s amine dendrons were used to modify the microspheres. Prior to dendronization films were prepared by blending chitosan with 18% of polyvinyl pyrrolidone (PVP), and casting the resulting mixture. The degree of dendronization reached was 28%. The microspheres were prepared by coacervation/precipitation, after which the surfaces were activated with either epychlorohydrine (ECH) or 1,4-butanediol diglycidyl ether (BDGE). The oxirane groups were utilized to form covalent bonds between chitosan and dendrons. The degree of dendronization yielded with Behera?s amine was 60% for both activating agents. When bis Behera?s amine was used, the dendronization reached values of 15 and 21% when ECH or BDGE were used, respectively. The dendronized products were characterized through spectroscopic and microscopic studies and by determination of swelling indexes. Only one of the surfaces was dendronized in every film, which therefore presented a hydrophobic and a hydrophilic surface. Since these films maintain the properties of chitosan, they offer interesting potential as dressings for exuding wounds. The different surfaces make the microspheres potentially applicable as carriers for delivery and controlled release of drugs.Fil: Aldana, Ana Agustina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; ArgentinaFil: Martinelli, Marisa. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; ArgentinaFil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; ArgentinaWiley2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14731Aldana, Ana Agustina; Martinelli, Marisa; Strumia, Miriam Cristina; Synthesis and Properties of Dendronized Chitosan; Wiley; Macromolecular Symposia; 298; 1; 12-2010; 99-1071022-13601521-3900enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/masy.201000035/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/masy.201000035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:26Zoai:ri.conicet.gov.ar:11336/14731instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:26.369CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis and Properties of Dendronized Chitosan
title Synthesis and Properties of Dendronized Chitosan
spellingShingle Synthesis and Properties of Dendronized Chitosan
Aldana, Ana Agustina
Biomaterials
Dendronization
Dendronized Chitosan
Functional Polymers
title_short Synthesis and Properties of Dendronized Chitosan
title_full Synthesis and Properties of Dendronized Chitosan
title_fullStr Synthesis and Properties of Dendronized Chitosan
title_full_unstemmed Synthesis and Properties of Dendronized Chitosan
title_sort Synthesis and Properties of Dendronized Chitosan
dc.creator.none.fl_str_mv Aldana, Ana Agustina
Martinelli, Marisa
Strumia, Miriam Cristina
author Aldana, Ana Agustina
author_facet Aldana, Ana Agustina
Martinelli, Marisa
Strumia, Miriam Cristina
author_role author
author2 Martinelli, Marisa
Strumia, Miriam Cristina
author2_role author
author
dc.subject.none.fl_str_mv Biomaterials
Dendronization
Dendronized Chitosan
Functional Polymers
topic Biomaterials
Dendronization
Dendronized Chitosan
Functional Polymers
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chitosan films and microspheres were prepared and their surfaces were functionalized with first generation dendritic molecules. The films were modified by Weisocyanate dendron, while Behera?s and bis Behera?s amine dendrons were used to modify the microspheres. Prior to dendronization films were prepared by blending chitosan with 18% of polyvinyl pyrrolidone (PVP), and casting the resulting mixture. The degree of dendronization reached was 28%. The microspheres were prepared by coacervation/precipitation, after which the surfaces were activated with either epychlorohydrine (ECH) or 1,4-butanediol diglycidyl ether (BDGE). The oxirane groups were utilized to form covalent bonds between chitosan and dendrons. The degree of dendronization yielded with Behera?s amine was 60% for both activating agents. When bis Behera?s amine was used, the dendronization reached values of 15 and 21% when ECH or BDGE were used, respectively. The dendronized products were characterized through spectroscopic and microscopic studies and by determination of swelling indexes. Only one of the surfaces was dendronized in every film, which therefore presented a hydrophobic and a hydrophilic surface. Since these films maintain the properties of chitosan, they offer interesting potential as dressings for exuding wounds. The different surfaces make the microspheres potentially applicable as carriers for delivery and controlled release of drugs.
Fil: Aldana, Ana Agustina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Fil: Martinelli, Marisa. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
description Chitosan films and microspheres were prepared and their surfaces were functionalized with first generation dendritic molecules. The films were modified by Weisocyanate dendron, while Behera?s and bis Behera?s amine dendrons were used to modify the microspheres. Prior to dendronization films were prepared by blending chitosan with 18% of polyvinyl pyrrolidone (PVP), and casting the resulting mixture. The degree of dendronization reached was 28%. The microspheres were prepared by coacervation/precipitation, after which the surfaces were activated with either epychlorohydrine (ECH) or 1,4-butanediol diglycidyl ether (BDGE). The oxirane groups were utilized to form covalent bonds between chitosan and dendrons. The degree of dendronization yielded with Behera?s amine was 60% for both activating agents. When bis Behera?s amine was used, the dendronization reached values of 15 and 21% when ECH or BDGE were used, respectively. The dendronized products were characterized through spectroscopic and microscopic studies and by determination of swelling indexes. Only one of the surfaces was dendronized in every film, which therefore presented a hydrophobic and a hydrophilic surface. Since these films maintain the properties of chitosan, they offer interesting potential as dressings for exuding wounds. The different surfaces make the microspheres potentially applicable as carriers for delivery and controlled release of drugs.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14731
Aldana, Ana Agustina; Martinelli, Marisa; Strumia, Miriam Cristina; Synthesis and Properties of Dendronized Chitosan; Wiley; Macromolecular Symposia; 298; 1; 12-2010; 99-107
1022-1360
1521-3900
url http://hdl.handle.net/11336/14731
identifier_str_mv Aldana, Ana Agustina; Martinelli, Marisa; Strumia, Miriam Cristina; Synthesis and Properties of Dendronized Chitosan; Wiley; Macromolecular Symposia; 298; 1; 12-2010; 99-107
1022-1360
1521-3900
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/masy.201000035/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/masy.201000035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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