Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes

Autores
Mengatto, Luciano Nicolas; Ferreyra, Maria Graciela; Rubiolo, Amelia Catalina; Rintoul, Ignacio; Luna, Julio Alberto
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chitosan membranes with different cross-linking density were prepared by modifying cross-linking time. Sodium tripolyphosphate was the cross-linking agent. A pulsed nuclear magnetic resonance study was performed on uncross-linked and cross-linked membranes. Different fraction of water molecules were identified in different zones within the membranes. The ratio of water molecules per chitosan repeating unit were calculated. A maximum of twelve water molecules were tightly coordinated to the chitosan repeating unit. Also, a very small water molecule fraction was identified but it was mobile enough as not to contribute to the dipolar interactions. The cross-linking reaction could lead to the formation of hydrophilic and hydrophobic interactions. These two types of interactions could result in the coexistence of a network formed by hydrophilic and hydrophobic micropores. This knowledge could be useful for the interpretation of results of hydrophobic drugs permeation across hydrophilic membranes. For example, the increment of estradiol fluxes across chitosan membranes with an increase in cross-linking density. © 2013 Elsevier B.V. All rights reserved.
Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Ferreyra, Maria Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Rubiolo, Amelia Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Materia
BIOMATERIALS
DIFFUSION
NUCLEAR MAGNETIC RESONANCE (NMR)
POLYMERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8678
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hydrophilic and hydrophobic interactions in cross-linked chitosan membranesMengatto, Luciano NicolasFerreyra, Maria GracielaRubiolo, Amelia CatalinaRintoul, IgnacioLuna, Julio AlbertoBIOMATERIALSDIFFUSIONNUCLEAR MAGNETIC RESONANCE (NMR)POLYMERShttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Chitosan membranes with different cross-linking density were prepared by modifying cross-linking time. Sodium tripolyphosphate was the cross-linking agent. A pulsed nuclear magnetic resonance study was performed on uncross-linked and cross-linked membranes. Different fraction of water molecules were identified in different zones within the membranes. The ratio of water molecules per chitosan repeating unit were calculated. A maximum of twelve water molecules were tightly coordinated to the chitosan repeating unit. Also, a very small water molecule fraction was identified but it was mobile enough as not to contribute to the dipolar interactions. The cross-linking reaction could lead to the formation of hydrophilic and hydrophobic interactions. These two types of interactions could result in the coexistence of a network formed by hydrophilic and hydrophobic micropores. This knowledge could be useful for the interpretation of results of hydrophobic drugs permeation across hydrophilic membranes. For example, the increment of estradiol fluxes across chitosan membranes with an increase in cross-linking density. © 2013 Elsevier B.V. All rights reserved.Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaFil: Ferreyra, Maria Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaFil: Rubiolo, Amelia Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaFil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaElsevier Science Sa2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8678Mengatto, Luciano Nicolas; Ferreyra, Maria Graciela; Rubiolo, Amelia Catalina; Rintoul, Ignacio; Luna, Julio Alberto; Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes; Elsevier Science Sa; Materials Chemistry and Physics; 139; 1; 2-2013; 181-1860254-0584enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.matchemphys.2013.01.019info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0254058413000631info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:19:43Zoai:ri.conicet.gov.ar:11336/8678instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:19:44.109CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
title Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
spellingShingle Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
Mengatto, Luciano Nicolas
BIOMATERIALS
DIFFUSION
NUCLEAR MAGNETIC RESONANCE (NMR)
POLYMERS
title_short Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
title_full Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
title_fullStr Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
title_full_unstemmed Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
title_sort Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
dc.creator.none.fl_str_mv Mengatto, Luciano Nicolas
Ferreyra, Maria Graciela
Rubiolo, Amelia Catalina
Rintoul, Ignacio
Luna, Julio Alberto
author Mengatto, Luciano Nicolas
author_facet Mengatto, Luciano Nicolas
Ferreyra, Maria Graciela
Rubiolo, Amelia Catalina
Rintoul, Ignacio
Luna, Julio Alberto
author_role author
author2 Ferreyra, Maria Graciela
Rubiolo, Amelia Catalina
Rintoul, Ignacio
Luna, Julio Alberto
author2_role author
author
author
author
dc.subject.none.fl_str_mv BIOMATERIALS
DIFFUSION
NUCLEAR MAGNETIC RESONANCE (NMR)
POLYMERS
topic BIOMATERIALS
DIFFUSION
NUCLEAR MAGNETIC RESONANCE (NMR)
POLYMERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Chitosan membranes with different cross-linking density were prepared by modifying cross-linking time. Sodium tripolyphosphate was the cross-linking agent. A pulsed nuclear magnetic resonance study was performed on uncross-linked and cross-linked membranes. Different fraction of water molecules were identified in different zones within the membranes. The ratio of water molecules per chitosan repeating unit were calculated. A maximum of twelve water molecules were tightly coordinated to the chitosan repeating unit. Also, a very small water molecule fraction was identified but it was mobile enough as not to contribute to the dipolar interactions. The cross-linking reaction could lead to the formation of hydrophilic and hydrophobic interactions. These two types of interactions could result in the coexistence of a network formed by hydrophilic and hydrophobic micropores. This knowledge could be useful for the interpretation of results of hydrophobic drugs permeation across hydrophilic membranes. For example, the increment of estradiol fluxes across chitosan membranes with an increase in cross-linking density. © 2013 Elsevier B.V. All rights reserved.
Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Ferreyra, Maria Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Rubiolo, Amelia Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
description Chitosan membranes with different cross-linking density were prepared by modifying cross-linking time. Sodium tripolyphosphate was the cross-linking agent. A pulsed nuclear magnetic resonance study was performed on uncross-linked and cross-linked membranes. Different fraction of water molecules were identified in different zones within the membranes. The ratio of water molecules per chitosan repeating unit were calculated. A maximum of twelve water molecules were tightly coordinated to the chitosan repeating unit. Also, a very small water molecule fraction was identified but it was mobile enough as not to contribute to the dipolar interactions. The cross-linking reaction could lead to the formation of hydrophilic and hydrophobic interactions. These two types of interactions could result in the coexistence of a network formed by hydrophilic and hydrophobic micropores. This knowledge could be useful for the interpretation of results of hydrophobic drugs permeation across hydrophilic membranes. For example, the increment of estradiol fluxes across chitosan membranes with an increase in cross-linking density. © 2013 Elsevier B.V. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8678
Mengatto, Luciano Nicolas; Ferreyra, Maria Graciela; Rubiolo, Amelia Catalina; Rintoul, Ignacio; Luna, Julio Alberto; Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes; Elsevier Science Sa; Materials Chemistry and Physics; 139; 1; 2-2013; 181-186
0254-0584
url http://hdl.handle.net/11336/8678
identifier_str_mv Mengatto, Luciano Nicolas; Ferreyra, Maria Graciela; Rubiolo, Amelia Catalina; Rintoul, Ignacio; Luna, Julio Alberto; Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes; Elsevier Science Sa; Materials Chemistry and Physics; 139; 1; 2-2013; 181-186
0254-0584
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.matchemphys.2013.01.019
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0254058413000631
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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