Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse
- Autores
- Cardinali, Daniel Pedro; Golombek, Diego A.; Rosenstein, Ruth E.; Brusco, Luis I.; Vigo, Daniel Eduardo
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión aceptada
- Descripción
- Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina
Fil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Golombek, Diego A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina
Fil: Rosenstein, Ruth E. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina
Fil: Brusco, Luis I. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas José de San Martín. Centro de Neuropsiquiatría y Neurología de la Conducta; Argentina
Fil: Brusco, Luis I. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Vigo, Daniel Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina
Abstract: The abuse of benzodiazepine (BZP) and Z drugs has become, due to the tolerance and dependence theyproduce, a serious public health problem. Thirty years ago, we demonstrated in experimental animalsthe interaction of melatonin with central BZD receptors, and in 1997 we published the first series ofelderly patients who reduced BZP consumption after melatonin treatment. Almost every single neuron inthe hypothalamic suprachiasmatic nuclei (SCN), the central pacemaker of the circadian system, contains-aminobutyric acid (GABA) and many results in animals point out to a melatonin interaction with GABA-containing neurons. In addition, central-type BZD antagonism, that obliterates GABAAreceptor function,blunted most behavioral effects of melatonin including sleep. Melatonin is involved in the regulation ofhuman sleep. This is supported by the temporal relationship between the rise of plasma melatonin levelsand sleep propensity as well as by the sleep-promoting effects of exogenously administered melatonin.Both meta-analyses and consensus agreements give support to the therapeutic use of melatonin in sleepdisorders. This action is attributed to MT1and MT2melatoninergic receptors localized in the SCN, as wellas in other brain areas. This review discusses available data on the efficacy of melatonin to curtail chronicBZD/Z drug use in insomnia patients. A major advantage is that melatonin has a very safe profile, it isusually remarkably well tolerated and, in some studies, it has been administered to patients at very largedoses and for long periods of time, without any potentiality of abuse. Further studies on this applicationof melatonin are warranted. - Fuente
- Pharmacological Research Vol. 109, 2016
- Materia
-
MEDICINA
INSOMNIO
MELATONINA
SUEÑO
BIOMEDICINA
BENZODIACEPINAS
ABUSO DE DROGAS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/1465
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Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuseCardinali, Daniel PedroGolombek, Diego A.Rosenstein, Ruth E.Brusco, Luis I.Vigo, Daniel EduardoMEDICINAINSOMNIOMELATONINASUEÑOBIOMEDICINABENZODIACEPINASABUSO DE DROGASFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; ArgentinaFil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Golombek, Diego A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; ArgentinaFil: Rosenstein, Ruth E. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; ArgentinaFil: Brusco, Luis I. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas José de San Martín. Centro de Neuropsiquiatría y Neurología de la Conducta; ArgentinaFil: Brusco, Luis I. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; ArgentinaFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Vigo, Daniel Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; ArgentinaAbstract: The abuse of benzodiazepine (BZP) and Z drugs has become, due to the tolerance and dependence theyproduce, a serious public health problem. Thirty years ago, we demonstrated in experimental animalsthe interaction of melatonin with central BZD receptors, and in 1997 we published the first series ofelderly patients who reduced BZP consumption after melatonin treatment. Almost every single neuron inthe hypothalamic suprachiasmatic nuclei (SCN), the central pacemaker of the circadian system, contains-aminobutyric acid (GABA) and many results in animals point out to a melatonin interaction with GABA-containing neurons. In addition, central-type BZD antagonism, that obliterates GABAAreceptor function,blunted most behavioral effects of melatonin including sleep. Melatonin is involved in the regulation ofhuman sleep. This is supported by the temporal relationship between the rise of plasma melatonin levelsand sleep propensity as well as by the sleep-promoting effects of exogenously administered melatonin.Both meta-analyses and consensus agreements give support to the therapeutic use of melatonin in sleepdisorders. This action is attributed to MT1and MT2melatoninergic receptors localized in the SCN, as wellas in other brain areas. This review discusses available data on the efficacy of melatonin to curtail chronicBZD/Z drug use in insomnia patients. A major advantage is that melatonin has a very safe profile, it isusually remarkably well tolerated and, in some studies, it has been administered to patients at very largedoses and for long periods of time, without any potentiality of abuse. Further studies on this applicationof melatonin are warranted.Elsevier2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/14651096-1186 (online)1043-6618 (impreso)10.1016/j.phrs.2015.08.016Cardinali D. P., et al. Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse [en línea]. Postprint del documento publicado en Pharmacological Research. 2016, 109. doi: 10.1016/j.phrs.2015.08.016. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1465Pharmacological Research Vol. 109, 2016reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:17Zoai:ucacris:123456789/1465instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:17.95Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse |
title |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse |
spellingShingle |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse Cardinali, Daniel Pedro MEDICINA INSOMNIO MELATONINA SUEÑO BIOMEDICINA BENZODIACEPINAS ABUSO DE DROGAS |
title_short |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse |
title_full |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse |
title_fullStr |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse |
title_full_unstemmed |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse |
title_sort |
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse |
dc.creator.none.fl_str_mv |
Cardinali, Daniel Pedro Golombek, Diego A. Rosenstein, Ruth E. Brusco, Luis I. Vigo, Daniel Eduardo |
author |
Cardinali, Daniel Pedro |
author_facet |
Cardinali, Daniel Pedro Golombek, Diego A. Rosenstein, Ruth E. Brusco, Luis I. Vigo, Daniel Eduardo |
author_role |
author |
author2 |
Golombek, Diego A. Rosenstein, Ruth E. Brusco, Luis I. Vigo, Daniel Eduardo |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
MEDICINA INSOMNIO MELATONINA SUEÑO BIOMEDICINA BENZODIACEPINAS ABUSO DE DROGAS |
topic |
MEDICINA INSOMNIO MELATONINA SUEÑO BIOMEDICINA BENZODIACEPINAS ABUSO DE DROGAS |
dc.description.none.fl_txt_mv |
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina Fil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina Fil: Golombek, Diego A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina Fil: Rosenstein, Ruth E. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina Fil: Brusco, Luis I. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas José de San Martín. Centro de Neuropsiquiatría y Neurología de la Conducta; Argentina Fil: Brusco, Luis I. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina Fil: Vigo, Daniel Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental; Argentina Abstract: The abuse of benzodiazepine (BZP) and Z drugs has become, due to the tolerance and dependence theyproduce, a serious public health problem. Thirty years ago, we demonstrated in experimental animalsthe interaction of melatonin with central BZD receptors, and in 1997 we published the first series ofelderly patients who reduced BZP consumption after melatonin treatment. Almost every single neuron inthe hypothalamic suprachiasmatic nuclei (SCN), the central pacemaker of the circadian system, contains-aminobutyric acid (GABA) and many results in animals point out to a melatonin interaction with GABA-containing neurons. In addition, central-type BZD antagonism, that obliterates GABAAreceptor function,blunted most behavioral effects of melatonin including sleep. Melatonin is involved in the regulation ofhuman sleep. This is supported by the temporal relationship between the rise of plasma melatonin levelsand sleep propensity as well as by the sleep-promoting effects of exogenously administered melatonin.Both meta-analyses and consensus agreements give support to the therapeutic use of melatonin in sleepdisorders. This action is attributed to MT1and MT2melatoninergic receptors localized in the SCN, as wellas in other brain areas. This review discusses available data on the efficacy of melatonin to curtail chronicBZD/Z drug use in insomnia patients. A major advantage is that melatonin has a very safe profile, it isusually remarkably well tolerated and, in some studies, it has been administered to patients at very largedoses and for long periods of time, without any potentiality of abuse. Further studies on this applicationof melatonin are warranted. |
description |
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
acceptedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/1465 1096-1186 (online) 1043-6618 (impreso) 10.1016/j.phrs.2015.08.016 Cardinali D. P., et al. Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse [en línea]. Postprint del documento publicado en Pharmacological Research. 2016, 109. doi: 10.1016/j.phrs.2015.08.016. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1465 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1465 |
identifier_str_mv |
1096-1186 (online) 1043-6618 (impreso) 10.1016/j.phrs.2015.08.016 Cardinali D. P., et al. Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse [en línea]. Postprint del documento publicado en Pharmacological Research. 2016, 109. doi: 10.1016/j.phrs.2015.08.016. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1465 |
dc.language.none.fl_str_mv |
eng eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
Pharmacological Research Vol. 109, 2016 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
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Repositorio Institucional (UCA) |
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Repositorio Institucional (UCA) |
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Pontificia Universidad Católica Argentina |
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Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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13.13397 |