High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection

Autores
Cardinali, Daniel Pedro
Año de publicación
2020
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.
Fuente
Melatonin Research. 2020, 3(3)
Materia
MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/10355
Acceder
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oai_identifier_str oai:ucacris:123456789/10355
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infectionCardinali, Daniel PedroMELATONINACORONAVIRUSCOVID-19ACCIDENTE CEREBROVASCULARNEUROPROTECCIONNEUROLOGIAFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaAbstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.ST Bio-Life2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/103552641-028110.32794/11250064Cardinali, D.P. High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection [en línea]. Melatonin Research. 2020, 3(3). doi:10.32794/11250064 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10355Melatonin Research. 2020, 3(3)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaspainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:57:27Zoai:ucacris:123456789/10355instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:57:27.775Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
spellingShingle High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
Cardinali, Daniel Pedro
MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
title_short High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_full High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_fullStr High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_full_unstemmed High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_sort High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
dc.creator.none.fl_str_mv Cardinali, Daniel Pedro
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
author_role author
dc.subject.none.fl_str_mv MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
topic MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
dc.description.none.fl_txt_mv Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.
description Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/10355
2641-0281
10.32794/11250064
Cardinali, D.P. High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection [en línea]. Melatonin Research. 2020, 3(3). doi:10.32794/11250064 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10355
url https://repositorio.uca.edu.ar/handle/123456789/10355
identifier_str_mv 2641-0281
10.32794/11250064
Cardinali, D.P. High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection [en línea]. Melatonin Research. 2020, 3(3). doi:10.32794/11250064 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10355
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ST Bio-Life
publisher.none.fl_str_mv ST Bio-Life
dc.source.none.fl_str_mv Melatonin Research. 2020, 3(3)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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