High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection

Autores
Cardinali, Daniel Pedro
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, antiinflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.
Fuente
Melatonin Research. 2020, 3 (3)
Materia
COVID-19
NEUROPROTECCION
NEUROLOGIA
MELATONINA
CORONAVIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/13678
Acceder
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oai_identifier_str oai:ucacris:123456789/13678
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infectionCardinali, Daniel PedroCOVID-19NEUROPROTECCIONNEUROLOGIAMELATONINACORONAVIRUSFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; ArgentinaAbstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, antiinflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/1367810.32794/11250064Cardinali, D. P. High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection [en línea]. Melatonin Research. 2020, 3 (3). doi: 10.32794/11250064. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13678Melatonin Research. 2020, 3 (3)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:30Zoai:ucacris:123456789/13678instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:30.4Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
spellingShingle High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
Cardinali, Daniel Pedro
COVID-19
NEUROPROTECCION
NEUROLOGIA
MELATONINA
CORONAVIRUS
title_short High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_full High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_fullStr High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_full_unstemmed High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_sort High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
dc.creator.none.fl_str_mv Cardinali, Daniel Pedro
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
author_role author
dc.subject.none.fl_str_mv COVID-19
NEUROPROTECCION
NEUROLOGIA
MELATONINA
CORONAVIRUS
topic COVID-19
NEUROPROTECCION
NEUROLOGIA
MELATONINA
CORONAVIRUS
dc.description.none.fl_txt_mv Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, antiinflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.
description Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/13678
10.32794/11250064
Cardinali, D. P. High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection [en línea]. Melatonin Research. 2020, 3 (3). doi: 10.32794/11250064. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13678
url https://repositorio.uca.edu.ar/handle/123456789/13678
identifier_str_mv 10.32794/11250064
Cardinali, D. P. High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection [en línea]. Melatonin Research. 2020, 3 (3). doi: 10.32794/11250064. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13678
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Melatonin Research. 2020, 3 (3)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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