Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration

Autores
Quintá, Héctor R.; Barrantes, Francisco José
Año de publicación
2019
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Fil: Quintá, Héctor R. Hospital Alemán. Laboratorio de Medicina Experimental Dr. J. Toblli; Argentina
Fil: Quintá, Héctor R. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Integrity of the plasma membrane is essential for the maintenance of physiological conditions, metabolic activity and the shape of eukaryotic cells. In neurons, the plasma membrane surrounding the axon—the axolemma—fulfills all these functions plus those inherent to the specific function of the neuron: maintaining the membrane potential by the regulated and concerted operation of ion-selective channels. Membrane expansion and neurite growth are directly linked through intricate cellular signaling mechanisms during the early stages of embryonic development. During axonal development there is an increase in the surface area of the axolemma which provokes an increase in membrane tension. Membrane insertion involved in axonal growth reduces the membrane tension, and this in turn allows distal membrane expansion and axonal extension. Under certain pathological conditions, such as spinal cord and traumatic brain injuries, the axolemmal damage results in different degrees of neuronal degeneration due to unregulated ionic influx, followed by oxidative damage, finally triggering neuronal apoptosis. Neurons possess counteractive mechanisms to arrest these degenerative processes which involve sealing the axolemma as a first step toward membrane repair, followed by attempts at axonal extension. In this review we address the main molecular actors and mechanisms involved in axonal growth during embryonic development and the recapitulation of these mechanisms during the posttraumatic regeneration process. We also discuss the efficacy of some classical and novel therapeutic approaches to axolemmal sealing and repair in different pathologies.
Fuente
Andrade. L.O. (ed.). Plasma Membrane Repair (Current Topics in Membranes, 84). Elsevier, 2019
Materia
AXONES
MEMBRANAS CELULARES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/14690

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oai_identifier_str oai:ucacris:123456789/14690
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restorationQuintá, Héctor R.Barrantes, Francisco JoséAXONESMEMBRANAS CELULARESFil: Quintá, Héctor R. Hospital Alemán. Laboratorio de Medicina Experimental Dr. J. Toblli; ArgentinaFil: Quintá, Héctor R. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; ArgentinaFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Integrity of the plasma membrane is essential for the maintenance of physiological conditions, metabolic activity and the shape of eukaryotic cells. In neurons, the plasma membrane surrounding the axon—the axolemma—fulfills all these functions plus those inherent to the specific function of the neuron: maintaining the membrane potential by the regulated and concerted operation of ion-selective channels. Membrane expansion and neurite growth are directly linked through intricate cellular signaling mechanisms during the early stages of embryonic development. During axonal development there is an increase in the surface area of the axolemma which provokes an increase in membrane tension. Membrane insertion involved in axonal growth reduces the membrane tension, and this in turn allows distal membrane expansion and axonal extension. Under certain pathological conditions, such as spinal cord and traumatic brain injuries, the axolemmal damage results in different degrees of neuronal degeneration due to unregulated ionic influx, followed by oxidative damage, finally triggering neuronal apoptosis. Neurons possess counteractive mechanisms to arrest these degenerative processes which involve sealing the axolemma as a first step toward membrane repair, followed by attempts at axonal extension. In this review we address the main molecular actors and mechanisms involved in axonal growth during embryonic development and the recapitulation of these mechanisms during the posttraumatic regeneration process. We also discuss the efficacy of some classical and novel therapeutic approaches to axolemmal sealing and repair in different pathologies.Elservier2019info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/14690978-0-12-817760-01063-582310.1016/bs.ctm.2019.07.00731610861Quintá, H.R., Barrantes, F.J. Damage and repair of the axolemmal membrane: From neural development to axonal trauma and restoration [en línea]. En: Andrade. L.O. (ed.). Plasma Membrane Repair (Current Topics in Membranes, 84). Elsevier, 2019 doi:10.1016/bs.ctm.2019.07.007 Disponible en:Andrade. L.O. (ed.). Plasma Membrane Repair (Current Topics in Membranes, 84). Elsevier, 2019reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:45Zoai:ucacris:123456789/14690instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:45.447Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
spellingShingle Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
Quintá, Héctor R.
AXONES
MEMBRANAS CELULARES
title_short Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_full Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_fullStr Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_full_unstemmed Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_sort Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
dc.creator.none.fl_str_mv Quintá, Héctor R.
Barrantes, Francisco José
author Quintá, Héctor R.
author_facet Quintá, Héctor R.
Barrantes, Francisco José
author_role author
author2 Barrantes, Francisco José
author2_role author
dc.subject.none.fl_str_mv AXONES
MEMBRANAS CELULARES
topic AXONES
MEMBRANAS CELULARES
dc.description.none.fl_txt_mv Fil: Quintá, Héctor R. Hospital Alemán. Laboratorio de Medicina Experimental Dr. J. Toblli; Argentina
Fil: Quintá, Héctor R. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Integrity of the plasma membrane is essential for the maintenance of physiological conditions, metabolic activity and the shape of eukaryotic cells. In neurons, the plasma membrane surrounding the axon—the axolemma—fulfills all these functions plus those inherent to the specific function of the neuron: maintaining the membrane potential by the regulated and concerted operation of ion-selective channels. Membrane expansion and neurite growth are directly linked through intricate cellular signaling mechanisms during the early stages of embryonic development. During axonal development there is an increase in the surface area of the axolemma which provokes an increase in membrane tension. Membrane insertion involved in axonal growth reduces the membrane tension, and this in turn allows distal membrane expansion and axonal extension. Under certain pathological conditions, such as spinal cord and traumatic brain injuries, the axolemmal damage results in different degrees of neuronal degeneration due to unregulated ionic influx, followed by oxidative damage, finally triggering neuronal apoptosis. Neurons possess counteractive mechanisms to arrest these degenerative processes which involve sealing the axolemma as a first step toward membrane repair, followed by attempts at axonal extension. In this review we address the main molecular actors and mechanisms involved in axonal growth during embryonic development and the recapitulation of these mechanisms during the posttraumatic regeneration process. We also discuss the efficacy of some classical and novel therapeutic approaches to axolemmal sealing and repair in different pathologies.
description Fil: Quintá, Héctor R. Hospital Alemán. Laboratorio de Medicina Experimental Dr. J. Toblli; Argentina
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/14690
978-0-12-817760-0
1063-5823
10.1016/bs.ctm.2019.07.007
31610861
Quintá, H.R., Barrantes, F.J. Damage and repair of the axolemmal membrane: From neural development to axonal trauma and restoration [en línea]. En: Andrade. L.O. (ed.). Plasma Membrane Repair (Current Topics in Membranes, 84). Elsevier, 2019 doi:10.1016/bs.ctm.2019.07.007 Disponible en:
url https://repositorio.uca.edu.ar/handle/123456789/14690
identifier_str_mv 978-0-12-817760-0
1063-5823
10.1016/bs.ctm.2019.07.007
31610861
Quintá, H.R., Barrantes, F.J. Damage and repair of the axolemmal membrane: From neural development to axonal trauma and restoration [en línea]. En: Andrade. L.O. (ed.). Plasma Membrane Repair (Current Topics in Membranes, 84). Elsevier, 2019 doi:10.1016/bs.ctm.2019.07.007 Disponible en:
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elservier
publisher.none.fl_str_mv Elservier
dc.source.none.fl_str_mv Andrade. L.O. (ed.). Plasma Membrane Repair (Current Topics in Membranes, 84). Elsevier, 2019
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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