Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy

• Autores: Georges, Claire; Pérez Lloret, Santiago; Ory Magne, Fabienne; Fabbri, Margherita; Foubert Samier, Alexandra; Meissner, Wassilios G.; Rascol, Olivier; Pavy-Le Traon, Anne
• Año de publicación: 2022
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Parkinsonism & Related Disorders. 2022, 103
• Materia: ATROFIA MULTISISTÉMICA; ENFERMEDADES NEURODEGENERATIVAS; DISFUNCION VENTRICULAR; SISTEMA NERVIOSO AUTONOMO; SUDORACIÓN; HIPERTENSION ARTERIAL
• Institución: Pontificia Universidad Católica Argentina

Fil: Georges, Claire. Centro de Referencia para la Atrofia Multisistémica. Departamento de Neurología; Francia
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Laboratorio de Investigación en Ciencia de Datos; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ory Magne, Fabienne. Centro de Referencia para la Atrofia Multisistémica. Departamento de Neurología; Francia
Fil: Fabbri, Margherita. Centro de Referencia para la Atrofia Multisistémica. Departamento de Neurología; Francia
Fil: Foubert-Samier, Alexandra. Hospital Universitario de Burdeos. Departamento de Neurología de Enfermedades Neurodegenerativas; Francia
Fil: Foubert-Samier, Alexandra. Universidad de Burdeos. Instituto de Enfermedades Neurodegenerativas; Francia
Fil: Meissner, Wassilios G. Hospital Universitario de Burdeos. Departamento de Neurología de Enfermedades Neurodegenerativas; Francia
Fil: Meissner, Wassilios G. Universidad de Burdeos. Instituto de Enfermedades Neurodegenerativas; Francia
Fil: Meissner, Wassilios G. Universidad de Otago. Departamento de Medicina. Instituto de Investigación del Cerebro; Nueva Zelanda
Fil: Rascol, Olivier. Centro de Referencia para la Atrofia Multisistémica. Departamento de Neurología; Francia
Fil: Rascol, Olivier. Universidad de Toulouse. Centro de Excelencia en Neurodegeneración NeuroToul. Centro de Investigación Clínica, Departamento de Farmacología Clínica y Neurociencias; Francia
Fil: Pavy-Le Traon, Anne. Centro de Referencia para la Atrofia Multisistémica. Departamento de Neurología; Francia
Fil: Pavy-Le Traon, Anne. Instituto de Enfermedades Metabólicas y Cardiovasculares; Francia
Abstract: Background: Multiple System Atrophy (MSA) is a rare neurodegenerative disease with pronounced autonomic failure (AF). Severe cardiovascular AF is associated with poor prognosis. Since sweating dysfunction is less well known, we investigated the interest of a quick and non-invasive assessment of sweating using electrochemical skin conductance (ESC) as a marker for AF in MSA. Methods: 138 MSA patients of the French Reference center for MSA with an annual follow-up including the Unified MSA Rating Scale (UMSARS), COMPASS (autonomic symptoms) and measurements of foot and hand ESC (Sudoscan®) participated to this study (age 65 ± 8 years, 66% probable MSA, 72% AMS-P). Statistical analysis included: (i) correlations between ESC and MSA type, age, disease duration, severity, blood pressure (BP), COMPASS, (ii) comparisons between groups with normal or abnormal ESC, and (iii) multivariate analysis by logistic regression. Relationships between severity progression during follow-up with ESC and other variables were modeled by Generalized Estimating Equation. Results: Hands and feet ESCs were abnormal in 81/138 (59%) and 93/138 (67%) cases, respectively. Abnormal ESCs were significantly correlated to disease severity and several features of AF. ESCs worsening over time was more pronounced than other autonomic features such as orthostatic hypotension. Abnormal ESCs at baseline were significantly associated with a higher progression of UMSARS’s score during follow-up. Conclusion: Sweating dysfunction assessed by ESC is frequent in MSA and is significantly related to disease severity and AF. The gradual decrease in ESC with disease duration could be useful as a quantitative marker of autonomic dysfunction.