New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study

Autores
Pavy Le Traon, Anne; Piedvache, A.; Pérez Lloret, Santiago; Calandra Buonara, G.; Cochen De Cock, V.; Colosimo, C.; Cortelli, P.; Debs, R.; Duerr, S.; Fanciulli, A.; Foubert Samier, A.; Gerdelat, Angela; Gurevich, T.; Krismer, F.; Poewe, W.; Tison, Francois; Tranchant, C.; Wenning, G.; Meissner, Wassilios G.; Rascol, Olivier
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: Orthostatic hypotension (OH) is a key feature of multiple system atrophy (MSA), a fatal progressive neurodegenerative disorder associated with autonomic failure, parkinsonism and ataxia. This study aims (1) to determine the clinical spectrum of OH in a large European cohort of patients with MSA and (2) to investigate whether a prolonged postural challenge increases the sensitivity to detect OH in MSA. Methods: Assessment of OH during a 10 min orthostatic test in 349 patients with MSA from seven centres of the European MSA-Study Group (age: 63.6±8.8 years; disease duration: 4.2±2.6 years). Assessment of a possible relationship between OH and MSA subtype (P with predominant parkinsonism or C with predominant cerebellar ataxia), Unified MSA Rating Scale (UMSARS) scores and drug intake. Results: 187 patients (54%) had moderate (>20 mm Hg (systolic blood pressure (SBP)) and/or >10 mm Hg (diastolic blood pressure (DBP)) or severe OH (>30 mm Hg (SBP) and/or >15 mm Hg (DBP)) within 3 min and 250 patients (72%) within 10 min. OH magnitude was significantly associated with disease severity (UMSARS I, II and IV), orthostatic symptoms (UMSARS I) and supine hypertension. OH severity was not associated with MSA subtype. Drug intake did not differ according to OH magnitude except for antihypertensive drugs being less frequently, and antihypotensive drugs more frequently, prescribed in severe OH. Conclusions: This is the largest study of OH in patients with MSA. Our data suggest that the sensitivity to pick up OH increases substantially by a prolonged 10 min orthostatic challenge. These results will help to improve OH management and the design of future clinical trials.
Fil: Pavy Le Traon, Anne. University Hospital of Toulouse; Francia. Inserm; Francia
Fil: Piedvache, A.. Université Paul Sabatier; Francia
Fil: Pérez Lloret, Santiago. University Hospital of Toulouse; Francia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Calandra Buonara, G.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; Italia
Fil: Cochen De Cock, V.. University Hospital of Toulouse; Francia. University of Montpellier; Francia
Fil: Colosimo, C.. Sapienza Università di Roma; Italia
Fil: Cortelli, P.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; Italia
Fil: Debs, R.. University Hospital of Toulouse; Francia
Fil: Duerr, S.. Universidad de Innsbruck; Austria
Fil: Fanciulli, A.. Universidad de Innsbruck; Austria
Fil: Foubert Samier, A.. Centre Hospitalier Universitaire de Bordeaux; Francia. Universite de Bordeaux; Francia
Fil: Gerdelat, Angela. University Hospital of Toulouse; Francia
Fil: Gurevich, T.. Tel-Aviv University; Israel
Fil: Krismer, F.. Universidad de Innsbruck; Austria
Fil: Poewe, W.. Universidad de Innsbruck; Austria
Fil: Tison, Francois. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; Francia
Fil: Tranchant, C.. University Hospital Hautepierre; Francia
Fil: Wenning, G.. Universidad de Innsbruck; Austria
Fil: Meissner, Wassilios G.. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; Francia
Fil: Rascol, Olivier. University Hospital of Toulouse; Francia
Materia
Atrofia Multisistémica
Hipotensión Ortostática
Reacciones Adversas Medicamentosas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38852
Acceder
id CONICETDig_2e0e383e24644ea8797973fc3b29d908
oai_identifier_str oai:ri.conicet.gov.ar:11336/38852
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort studyPavy Le Traon, AnnePiedvache, A.Pérez Lloret, SantiagoCalandra Buonara, G.Cochen De Cock, V.Colosimo, C.Cortelli, P.Debs, R.Duerr, S.Fanciulli, A.Foubert Samier, A.Gerdelat, AngelaGurevich, T.Krismer, F.Poewe, W.Tison, FrancoisTranchant, C.Wenning, G.Meissner, Wassilios G.Rascol, OlivierAtrofia MultisistémicaHipotensión OrtostáticaReacciones Adversas Medicamentosashttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objectives: Orthostatic hypotension (OH) is a key feature of multiple system atrophy (MSA), a fatal progressive neurodegenerative disorder associated with autonomic failure, parkinsonism and ataxia. This study aims (1) to determine the clinical spectrum of OH in a large European cohort of patients with MSA and (2) to investigate whether a prolonged postural challenge increases the sensitivity to detect OH in MSA. Methods: Assessment of OH during a 10 min orthostatic test in 349 patients with MSA from seven centres of the European MSA-Study Group (age: 63.6±8.8 years; disease duration: 4.2±2.6 years). Assessment of a possible relationship between OH and MSA subtype (P with predominant parkinsonism or C with predominant cerebellar ataxia), Unified MSA Rating Scale (UMSARS) scores and drug intake. Results: 187 patients (54%) had moderate (>20 mm Hg (systolic blood pressure (SBP)) and/or >10 mm Hg (diastolic blood pressure (DBP)) or severe OH (>30 mm Hg (SBP) and/or >15 mm Hg (DBP)) within 3 min and 250 patients (72%) within 10 min. OH magnitude was significantly associated with disease severity (UMSARS I, II and IV), orthostatic symptoms (UMSARS I) and supine hypertension. OH severity was not associated with MSA subtype. Drug intake did not differ according to OH magnitude except for antihypertensive drugs being less frequently, and antihypotensive drugs more frequently, prescribed in severe OH. Conclusions: This is the largest study of OH in patients with MSA. Our data suggest that the sensitivity to pick up OH increases substantially by a prolonged 10 min orthostatic challenge. These results will help to improve OH management and the design of future clinical trials.Fil: Pavy Le Traon, Anne. University Hospital of Toulouse; Francia. Inserm; FranciaFil: Piedvache, A.. Université Paul Sabatier; FranciaFil: Pérez Lloret, Santiago. University Hospital of Toulouse; Francia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Calandra Buonara, G.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; ItaliaFil: Cochen De Cock, V.. University Hospital of Toulouse; Francia. University of Montpellier; FranciaFil: Colosimo, C.. Sapienza Università di Roma; ItaliaFil: Cortelli, P.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; ItaliaFil: Debs, R.. University Hospital of Toulouse; FranciaFil: Duerr, S.. Universidad de Innsbruck; AustriaFil: Fanciulli, A.. Universidad de Innsbruck; AustriaFil: Foubert Samier, A.. Centre Hospitalier Universitaire de Bordeaux; Francia. Universite de Bordeaux; FranciaFil: Gerdelat, Angela. University Hospital of Toulouse; FranciaFil: Gurevich, T.. Tel-Aviv University; IsraelFil: Krismer, F.. Universidad de Innsbruck; AustriaFil: Poewe, W.. Universidad de Innsbruck; AustriaFil: Tison, Francois. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; FranciaFil: Tranchant, C.. University Hospital Hautepierre; FranciaFil: Wenning, G.. Universidad de Innsbruck; AustriaFil: Meissner, Wassilios G.. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; FranciaFil: Rascol, Olivier. University Hospital of Toulouse; FranciaB M J Publishing Group2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38852Pavy Le Traon, Anne; Piedvache, A.; Pérez Lloret, Santiago; Calandra Buonara, G.; Cochen De Cock, V.; et al.; New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study; B M J Publishing Group; Journal Of Neurology, Neurosurgery And Psychiatry; 87; 5; 5-2015; 1-90022-3050CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jnnp.bmj.com/content/87/5/554info:eu-repo/semantics/altIdentifier/doi/10.1136/jnnp-2014-309999info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:58Zoai:ri.conicet.gov.ar:11336/38852instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:59.157CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
title New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
spellingShingle New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
Pavy Le Traon, Anne
Atrofia Multisistémica
Hipotensión Ortostática
Reacciones Adversas Medicamentosas
title_short New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
title_full New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
title_fullStr New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
title_full_unstemmed New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
title_sort New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
dc.creator.none.fl_str_mv Pavy Le Traon, Anne
Piedvache, A.
Pérez Lloret, Santiago
Calandra Buonara, G.
Cochen De Cock, V.
Colosimo, C.
Cortelli, P.
Debs, R.
Duerr, S.
Fanciulli, A.
Foubert Samier, A.
Gerdelat, Angela
Gurevich, T.
Krismer, F.
Poewe, W.
Tison, Francois
Tranchant, C.
Wenning, G.
Meissner, Wassilios G.
Rascol, Olivier
author Pavy Le Traon, Anne
author_facet Pavy Le Traon, Anne
Piedvache, A.
Pérez Lloret, Santiago
Calandra Buonara, G.
Cochen De Cock, V.
Colosimo, C.
Cortelli, P.
Debs, R.
Duerr, S.
Fanciulli, A.
Foubert Samier, A.
Gerdelat, Angela
Gurevich, T.
Krismer, F.
Poewe, W.
Tison, Francois
Tranchant, C.
Wenning, G.
Meissner, Wassilios G.
Rascol, Olivier
author_role author
author2 Piedvache, A.
Pérez Lloret, Santiago
Calandra Buonara, G.
Cochen De Cock, V.
Colosimo, C.
Cortelli, P.
Debs, R.
Duerr, S.
Fanciulli, A.
Foubert Samier, A.
Gerdelat, Angela
Gurevich, T.
Krismer, F.
Poewe, W.
Tison, Francois
Tranchant, C.
Wenning, G.
Meissner, Wassilios G.
Rascol, Olivier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Atrofia Multisistémica
Hipotensión Ortostática
Reacciones Adversas Medicamentosas
topic Atrofia Multisistémica
Hipotensión Ortostática
Reacciones Adversas Medicamentosas
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: Orthostatic hypotension (OH) is a key feature of multiple system atrophy (MSA), a fatal progressive neurodegenerative disorder associated with autonomic failure, parkinsonism and ataxia. This study aims (1) to determine the clinical spectrum of OH in a large European cohort of patients with MSA and (2) to investigate whether a prolonged postural challenge increases the sensitivity to detect OH in MSA. Methods: Assessment of OH during a 10 min orthostatic test in 349 patients with MSA from seven centres of the European MSA-Study Group (age: 63.6±8.8 years; disease duration: 4.2±2.6 years). Assessment of a possible relationship between OH and MSA subtype (P with predominant parkinsonism or C with predominant cerebellar ataxia), Unified MSA Rating Scale (UMSARS) scores and drug intake. Results: 187 patients (54%) had moderate (>20 mm Hg (systolic blood pressure (SBP)) and/or >10 mm Hg (diastolic blood pressure (DBP)) or severe OH (>30 mm Hg (SBP) and/or >15 mm Hg (DBP)) within 3 min and 250 patients (72%) within 10 min. OH magnitude was significantly associated with disease severity (UMSARS I, II and IV), orthostatic symptoms (UMSARS I) and supine hypertension. OH severity was not associated with MSA subtype. Drug intake did not differ according to OH magnitude except for antihypertensive drugs being less frequently, and antihypotensive drugs more frequently, prescribed in severe OH. Conclusions: This is the largest study of OH in patients with MSA. Our data suggest that the sensitivity to pick up OH increases substantially by a prolonged 10 min orthostatic challenge. These results will help to improve OH management and the design of future clinical trials.
Fil: Pavy Le Traon, Anne. University Hospital of Toulouse; Francia. Inserm; Francia
Fil: Piedvache, A.. Université Paul Sabatier; Francia
Fil: Pérez Lloret, Santiago. University Hospital of Toulouse; Francia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Calandra Buonara, G.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; Italia
Fil: Cochen De Cock, V.. University Hospital of Toulouse; Francia. University of Montpellier; Francia
Fil: Colosimo, C.. Sapienza Università di Roma; Italia
Fil: Cortelli, P.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; Italia
Fil: Debs, R.. University Hospital of Toulouse; Francia
Fil: Duerr, S.. Universidad de Innsbruck; Austria
Fil: Fanciulli, A.. Universidad de Innsbruck; Austria
Fil: Foubert Samier, A.. Centre Hospitalier Universitaire de Bordeaux; Francia. Universite de Bordeaux; Francia
Fil: Gerdelat, Angela. University Hospital of Toulouse; Francia
Fil: Gurevich, T.. Tel-Aviv University; Israel
Fil: Krismer, F.. Universidad de Innsbruck; Austria
Fil: Poewe, W.. Universidad de Innsbruck; Austria
Fil: Tison, Francois. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; Francia
Fil: Tranchant, C.. University Hospital Hautepierre; Francia
Fil: Wenning, G.. Universidad de Innsbruck; Austria
Fil: Meissner, Wassilios G.. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; Francia
Fil: Rascol, Olivier. University Hospital of Toulouse; Francia
description Objectives: Orthostatic hypotension (OH) is a key feature of multiple system atrophy (MSA), a fatal progressive neurodegenerative disorder associated with autonomic failure, parkinsonism and ataxia. This study aims (1) to determine the clinical spectrum of OH in a large European cohort of patients with MSA and (2) to investigate whether a prolonged postural challenge increases the sensitivity to detect OH in MSA. Methods: Assessment of OH during a 10 min orthostatic test in 349 patients with MSA from seven centres of the European MSA-Study Group (age: 63.6±8.8 years; disease duration: 4.2±2.6 years). Assessment of a possible relationship between OH and MSA subtype (P with predominant parkinsonism or C with predominant cerebellar ataxia), Unified MSA Rating Scale (UMSARS) scores and drug intake. Results: 187 patients (54%) had moderate (>20 mm Hg (systolic blood pressure (SBP)) and/or >10 mm Hg (diastolic blood pressure (DBP)) or severe OH (>30 mm Hg (SBP) and/or >15 mm Hg (DBP)) within 3 min and 250 patients (72%) within 10 min. OH magnitude was significantly associated with disease severity (UMSARS I, II and IV), orthostatic symptoms (UMSARS I) and supine hypertension. OH severity was not associated with MSA subtype. Drug intake did not differ according to OH magnitude except for antihypertensive drugs being less frequently, and antihypotensive drugs more frequently, prescribed in severe OH. Conclusions: This is the largest study of OH in patients with MSA. Our data suggest that the sensitivity to pick up OH increases substantially by a prolonged 10 min orthostatic challenge. These results will help to improve OH management and the design of future clinical trials.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38852
Pavy Le Traon, Anne; Piedvache, A.; Pérez Lloret, Santiago; Calandra Buonara, G.; Cochen De Cock, V.; et al.; New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study; B M J Publishing Group; Journal Of Neurology, Neurosurgery And Psychiatry; 87; 5; 5-2015; 1-9
0022-3050
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38852
identifier_str_mv Pavy Le Traon, Anne; Piedvache, A.; Pérez Lloret, Santiago; Calandra Buonara, G.; Cochen De Cock, V.; et al.; New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study; B M J Publishing Group; Journal Of Neurology, Neurosurgery And Psychiatry; 87; 5; 5-2015; 1-9
0022-3050
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jnnp.bmj.com/content/87/5/554
info:eu-repo/semantics/altIdentifier/doi/10.1136/jnnp-2014-309999
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv B M J Publishing Group
publisher.none.fl_str_mv B M J Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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