Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents

• Autores: Burgueño, Adriana Laura; Juárez, Yamila R.; Genaro, Ana María; Tellechea, Mariana L.
• Año de publicación: 2019
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Psychoneuroendocrinology. 2019, 113.
• Materia: ESTRES PRENATAL; SINDROME METABOLICO; HORMONAS; PRESION SANGUINEA; PESO AL NACER
• Institución: Pontificia Universidad Católica Argentina

Fil: Burgueño, Adriana L. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Burgueño, Adriana L. Burgueñoa, Adriana L. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Juárez, Yamila R. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Juárez, Yamila R. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Genaro, Ana M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Genaro, Ana M. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Tellechea, Mariana L. Hospital de Niños Ricardo Gutiérrez. División de Endocrinología; Argentina , Consejo Nacional de Investigaciones Científicas y Técnicas - -
Fil: Tellechea, Mariana L. Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergadá"; Argentina
Fil: Tellechea, Mariana L. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was to quantitatively synthesize the available data on the effects of MS on offspring obesity, estimated indirectly by body mass (BM), body fat (BF) and plasma leptin; systolic blood pressure (SBP); plasma glucose (and insulin) and blood lipid concentrations. Methods: Literature was screened and summary estimates of the effect of MS outcomes were calculated by using random-effects models. Data on the effects of exogenous corticosteroid administration (or inhibition of 11β-HSD2) during pregnancy in rodents was analysed separately to characterize the direct phenotypic effects of prenatal corticosteroid excess (PCE). Results: We conducted 14 separate meta-analyses and synthesized relevant data on outcomes scarcely reported in literature. Both MS and PCE were associated with low birth weight without rapid catch-up growth resulting in decreased body mass later in life. Our analysis also revealed significant and contradictory effects on offspring adiposity. Little evidence was found for effects on glucose metabolism and blood lipids. We identified increased SBP in offspring exposed to PCE; however, there is not enough data to draw any conclusion about effects of MS on SBP. Conclusions: Neonatal weight proved to be decreased in offspring prenatally exposed to stress or corticosteroids, but laboratory rodents in the absence of a challenging environment did not show catch-up growth. The available evidence is inconclusive regarding the effect on adiposity revealing clear methodological and knowledge gaps. This meta-analysis also confirmed a significant positive association between PCE and SBP. Nevertheless, additional studies should address the association with MS.