Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress

Autores
Pascuan, C.G.; Di Rosso, M. E.; Pivoz-Avedikian, J.E.; Wald, Miriam Ruth; Zorrilla Zubilete, M.A.; Genaro, Ana María
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Pascuan, C.G. Instituto de Genética “Ewald A. Favret”; Argentina
Fil: Pascuan, C.G. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina
Fil: Di Rosso, M.E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; Argentina
Fil: Di Rosso, M.E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pivoz-Avedikian, J.E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Fil: Wald, M.R. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; Argentina
Fil: Wald, M.R. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zorrilla Zubilete, M.A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Fil: Zorrilla Zubilete, M.A. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Zorrilla Zubilete, M.A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zorrilla Zubilete, M.A. Universidad de Buenos Aires; Argentina
Fil: Genaro, A.M. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; Argentina
Fil: Genaro, A.M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Abstract:ESTRÉS PRENATAL Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated the participation of glucocorticoids, neurotrophins and cytokines in prenatal stress effects. For this purpose, pregnant mice were placed in a cylindrical restraint tube for 2 h daily during the last week of pregnancy. Control pregnant females were left undisturbed during their entire pregnancy period. Object-in-place task results showed that adult female mice exposed to prenatal stress exhibited an impairment in spatial memory. However, in the alternation test this memory deficit was only found in prenatally stressed mice submitted to chronic stress. This alteration occurred in parallel with a decrease in BDNF, an increase in glucocorticoid receptors and an alteration of Th1/Th2 in the hippocampus. Interestingly, these changes were observed in peripheral lymph nodes as well. However, none of the mentioned changes were observed in adult male mice. These results indicate that lymphoid cells could be good candidates as peripheral markers of susceptibility to behavioral alterations associated with prenatal exposure to stress.
Fuente
Physiology & Behavior Vol.173, 2017
Materia
ESTRES PRENATAL
MEMORIA ESPACIAL
NEUROTROFINAS
CORTICOSTERONA
TRASTORNOS DE LA MEMORIA
EMBARAZO
Nivel de accesibilidad
acceso embargado
Condiciones de uso
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/14598
Acceder
id RIUCA_c54d09f6e2740d5e728c2fb16eb79028
oai_identifier_str oai:ucacris:123456789/14598
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stressPascuan, C.G.Di Rosso, M. E.Pivoz-Avedikian, J.E.Wald, Miriam RuthZorrilla Zubilete, M.A.Genaro, Ana MaríaESTRES PRENATALMEMORIA ESPACIALNEUROTROFINASCORTICOSTERONATRASTORNOS DE LA MEMORIAEMBARAZOFil: Pascuan, C.G. Instituto de Genética “Ewald A. Favret”; ArgentinaFil: Pascuan, C.G. Centro de Investigación en Ciencias Veterinarias y Agronómicas; ArgentinaFil: Di Rosso, M.E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; ArgentinaFil: Di Rosso, M.E. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pivoz-Avedikian, J.E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; ArgentinaFil: Wald, M.R. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; ArgentinaFil: Wald, M.R. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zorrilla Zubilete, M.A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; ArgentinaFil: Zorrilla Zubilete, M.A. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Zorrilla Zubilete, M.A. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zorrilla Zubilete, M.A. Universidad de Buenos Aires; ArgentinaFil: Genaro, A.M. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; ArgentinaFil: Genaro, A.M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; ArgentinaAbstract:ESTRÉS PRENATAL Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated the participation of glucocorticoids, neurotrophins and cytokines in prenatal stress effects. For this purpose, pregnant mice were placed in a cylindrical restraint tube for 2 h daily during the last week of pregnancy. Control pregnant females were left undisturbed during their entire pregnancy period. Object-in-place task results showed that adult female mice exposed to prenatal stress exhibited an impairment in spatial memory. However, in the alternation test this memory deficit was only found in prenatally stressed mice submitted to chronic stress. This alteration occurred in parallel with a decrease in BDNF, an increase in glucocorticoid receptors and an alteration of Th1/Th2 in the hippocampus. Interestingly, these changes were observed in peripheral lymph nodes as well. However, none of the mentioned changes were observed in adult male mice. These results indicate that lymphoid cells could be good candidates as peripheral markers of susceptibility to behavioral alterations associated with prenatal exposure to stress.Elsevierinfo:eu-repo/date/embargoEnd/2100-01-012017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/145980031-93841873-507X (online)10.1016/j.physbeh.2017.01.04528167147Pascuan, C.G. et al. Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress [en línea]. Physiology & Behavior. 2017, 173. doi: 10.1016/j.physbeh.2017.01.045. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14598Physiology & Behavior Vol.173, 2017reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/embargoedAccess2025-07-03T10:58:43Zoai:ucacris:123456789/14598instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:43.77Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
spellingShingle Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
Pascuan, C.G.
ESTRES PRENATAL
MEMORIA ESPACIAL
NEUROTROFINAS
CORTICOSTERONA
TRASTORNOS DE LA MEMORIA
EMBARAZO
title_short Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_full Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_fullStr Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_full_unstemmed Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_sort Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
dc.creator.none.fl_str_mv Pascuan, C.G.
Di Rosso, M. E.
Pivoz-Avedikian, J.E.
Wald, Miriam Ruth
Zorrilla Zubilete, M.A.
Genaro, Ana María
author Pascuan, C.G.
author_facet Pascuan, C.G.
Di Rosso, M. E.
Pivoz-Avedikian, J.E.
Wald, Miriam Ruth
Zorrilla Zubilete, M.A.
Genaro, Ana María
author_role author
author2 Di Rosso, M. E.
Pivoz-Avedikian, J.E.
Wald, Miriam Ruth
Zorrilla Zubilete, M.A.
Genaro, Ana María
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ESTRES PRENATAL
MEMORIA ESPACIAL
NEUROTROFINAS
CORTICOSTERONA
TRASTORNOS DE LA MEMORIA
EMBARAZO
topic ESTRES PRENATAL
MEMORIA ESPACIAL
NEUROTROFINAS
CORTICOSTERONA
TRASTORNOS DE LA MEMORIA
EMBARAZO
dc.description.none.fl_txt_mv Fil: Pascuan, C.G. Instituto de Genética “Ewald A. Favret”; Argentina
Fil: Pascuan, C.G. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina
Fil: Di Rosso, M.E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; Argentina
Fil: Di Rosso, M.E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pivoz-Avedikian, J.E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Fil: Wald, M.R. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; Argentina
Fil: Wald, M.R. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zorrilla Zubilete, M.A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Fil: Zorrilla Zubilete, M.A. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Zorrilla Zubilete, M.A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zorrilla Zubilete, M.A. Universidad de Buenos Aires; Argentina
Fil: Genaro, A.M. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. a Instituto de Investigaciones Biomédicas; Argentina
Fil: Genaro, A.M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Abstract:ESTRÉS PRENATAL Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated the participation of glucocorticoids, neurotrophins and cytokines in prenatal stress effects. For this purpose, pregnant mice were placed in a cylindrical restraint tube for 2 h daily during the last week of pregnancy. Control pregnant females were left undisturbed during their entire pregnancy period. Object-in-place task results showed that adult female mice exposed to prenatal stress exhibited an impairment in spatial memory. However, in the alternation test this memory deficit was only found in prenatally stressed mice submitted to chronic stress. This alteration occurred in parallel with a decrease in BDNF, an increase in glucocorticoid receptors and an alteration of Th1/Th2 in the hippocampus. Interestingly, these changes were observed in peripheral lymph nodes as well. However, none of the mentioned changes were observed in adult male mice. These results indicate that lymphoid cells could be good candidates as peripheral markers of susceptibility to behavioral alterations associated with prenatal exposure to stress.
description Fil: Pascuan, C.G. Instituto de Genética “Ewald A. Favret”; Argentina
publishDate 2017
dc.date.none.fl_str_mv 2017
info:eu-repo/date/embargoEnd/2100-01-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/14598
0031-9384
1873-507X (online)
10.1016/j.physbeh.2017.01.045
28167147
Pascuan, C.G. et al. Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress [en línea]. Physiology & Behavior. 2017, 173. doi: 10.1016/j.physbeh.2017.01.045. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14598
url https://repositorio.uca.edu.ar/handle/123456789/14598
identifier_str_mv 0031-9384
1873-507X (online)
10.1016/j.physbeh.2017.01.045
28167147
Pascuan, C.G. et al. Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress [en línea]. Physiology & Behavior. 2017, 173. doi: 10.1016/j.physbeh.2017.01.045. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14598
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Physiology & Behavior Vol.173, 2017
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.070432

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