Melatonin signaling as a link between sleep and circadian biology : practical implications
- Autores
- Cardinali, Daniel Pedro; Brown, Gregory M.
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- parte de libro
- Estado
- versión publicada
- Descripción
- Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brown, Gregory M. University of Toronto. Centre for Addiction and Mental Health; Canadá
Abstract: Normal circadian rhythms are synchronized to a regular 24 h environmental light-dark cycle. Both the suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation. Melatonin exerts its chronophysiological action in part by acting through specific membrane receptors (MT1, MT2), which have been identified in SCN cells as well as in several neural and non-neural tissues. Both receptors have been cloned and share general features with other G protein linked receptors. Melatonin also exerts direct effects on intracellular proteins, such as calmodulin or tubulin, has strong free radical scavenger properties, which are non-receptor mediated, is an effective mitochondrial protector and may interact with proteasome to affect intracellular physiology. Within the SCN, melatonin reduces neuronal activity in a time-dependent manner. The disruption of these circadian mechanisms causes a number of sleep disorders known as circadian rhythm sleep disorders (CRSDs). CRSDs include delayed or advanced sleep phase syndromes; non-24 h sleep-wake rhythm disorder, time zone change syndrome (“jet lag”) and shift work sleep disorder. Disturbances in the circadian phase position of plasma melatonin levels have been found in all these disorders. In addition, comorbidity of severe circadian alterations with neurodegenerative diseases like Alzheimer’s disease (AD) has been documented. Currently there is sufficient evidence to implicate endogenous melatonin as an important mediator in CRSD pathophysiology. The documented efficacy of melatonin to reduce chronic benzodiazepine/Z drug use in insomnia patients is also discussed. - Fuente
- Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016
- Materia
-
MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/10185
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Melatonin signaling as a link between sleep and circadian biology : practical implicationsCardinali, Daniel PedroBrown, Gregory M.MELATONINASUEÑORITMO CIRCADIANOTRASTORNOS DEL SUEÑOBENZODIAZEPINASENFERMEDAD DE ALZHEIMERFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Brown, Gregory M. University of Toronto. Centre for Addiction and Mental Health; CanadáAbstract: Normal circadian rhythms are synchronized to a regular 24 h environmental light-dark cycle. Both the suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation. Melatonin exerts its chronophysiological action in part by acting through specific membrane receptors (MT1, MT2), which have been identified in SCN cells as well as in several neural and non-neural tissues. Both receptors have been cloned and share general features with other G protein linked receptors. Melatonin also exerts direct effects on intracellular proteins, such as calmodulin or tubulin, has strong free radical scavenger properties, which are non-receptor mediated, is an effective mitochondrial protector and may interact with proteasome to affect intracellular physiology. Within the SCN, melatonin reduces neuronal activity in a time-dependent manner. The disruption of these circadian mechanisms causes a number of sleep disorders known as circadian rhythm sleep disorders (CRSDs). CRSDs include delayed or advanced sleep phase syndromes; non-24 h sleep-wake rhythm disorder, time zone change syndrome (“jet lag”) and shift work sleep disorder. Disturbances in the circadian phase position of plasma melatonin levels have been found in all these disorders. In addition, comorbidity of severe circadian alterations with neurodegenerative diseases like Alzheimer’s disease (AD) has been documented. Currently there is sufficient evidence to implicate endogenous melatonin as an important mediator in CRSD pathophysiology. The documented efficacy of melatonin to reduce chronic benzodiazepine/Z drug use in insomnia patients is also discussed.Apple Academic Press2016info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/10185978-1-77188-346-7 (impreso)978-1-77188-347-4 (online)Cardinali, D. P., Brown, G. M. Melatonin signaling as a link between sleep and circadian biology : practical implications [en línea]. En: Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10185Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:57:25Zoai:ucacris:123456789/10185instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:57:25.871Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Melatonin signaling as a link between sleep and circadian biology : practical implications |
title |
Melatonin signaling as a link between sleep and circadian biology : practical implications |
spellingShingle |
Melatonin signaling as a link between sleep and circadian biology : practical implications Cardinali, Daniel Pedro MELATONINA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO BENZODIAZEPINAS ENFERMEDAD DE ALZHEIMER |
title_short |
Melatonin signaling as a link between sleep and circadian biology : practical implications |
title_full |
Melatonin signaling as a link between sleep and circadian biology : practical implications |
title_fullStr |
Melatonin signaling as a link between sleep and circadian biology : practical implications |
title_full_unstemmed |
Melatonin signaling as a link between sleep and circadian biology : practical implications |
title_sort |
Melatonin signaling as a link between sleep and circadian biology : practical implications |
dc.creator.none.fl_str_mv |
Cardinali, Daniel Pedro Brown, Gregory M. |
author |
Cardinali, Daniel Pedro |
author_facet |
Cardinali, Daniel Pedro Brown, Gregory M. |
author_role |
author |
author2 |
Brown, Gregory M. |
author2_role |
author |
dc.subject.none.fl_str_mv |
MELATONINA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO BENZODIAZEPINAS ENFERMEDAD DE ALZHEIMER |
topic |
MELATONINA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO BENZODIAZEPINAS ENFERMEDAD DE ALZHEIMER |
dc.description.none.fl_txt_mv |
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Brown, Gregory M. University of Toronto. Centre for Addiction and Mental Health; Canadá Abstract: Normal circadian rhythms are synchronized to a regular 24 h environmental light-dark cycle. Both the suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation. Melatonin exerts its chronophysiological action in part by acting through specific membrane receptors (MT1, MT2), which have been identified in SCN cells as well as in several neural and non-neural tissues. Both receptors have been cloned and share general features with other G protein linked receptors. Melatonin also exerts direct effects on intracellular proteins, such as calmodulin or tubulin, has strong free radical scavenger properties, which are non-receptor mediated, is an effective mitochondrial protector and may interact with proteasome to affect intracellular physiology. Within the SCN, melatonin reduces neuronal activity in a time-dependent manner. The disruption of these circadian mechanisms causes a number of sleep disorders known as circadian rhythm sleep disorders (CRSDs). CRSDs include delayed or advanced sleep phase syndromes; non-24 h sleep-wake rhythm disorder, time zone change syndrome (“jet lag”) and shift work sleep disorder. Disturbances in the circadian phase position of plasma melatonin levels have been found in all these disorders. In addition, comorbidity of severe circadian alterations with neurodegenerative diseases like Alzheimer’s disease (AD) has been documented. Currently there is sufficient evidence to implicate endogenous melatonin as an important mediator in CRSD pathophysiology. The documented efficacy of melatonin to reduce chronic benzodiazepine/Z drug use in insomnia patients is also discussed. |
description |
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_3248 info:ar-repo/semantics/parteDeLibro |
format |
bookPart |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/10185 978-1-77188-346-7 (impreso) 978-1-77188-347-4 (online) Cardinali, D. P., Brown, G. M. Melatonin signaling as a link between sleep and circadian biology : practical implications [en línea]. En: Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10185 |
url |
https://repositorio.uca.edu.ar/handle/123456789/10185 |
identifier_str_mv |
978-1-77188-346-7 (impreso) 978-1-77188-347-4 (online) Cardinali, D. P., Brown, G. M. Melatonin signaling as a link between sleep and circadian biology : practical implications [en línea]. En: Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10185 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Apple Academic Press |
publisher.none.fl_str_mv |
Apple Academic Press |
dc.source.none.fl_str_mv |
Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638351792275456 |
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13.13397 |