Melatonin signaling as a link between sleep and circadian biology : practical implications

Autores
Cardinali, Daniel Pedro; Brown, Gregory M.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brown, Gregory M. University of Toronto. Centre for Addiction and Mental Health; Canadá
Abstract: Normal circadian rhythms are synchronized to a regular 24 h environmental light-dark cycle. Both the suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation. Melatonin exerts its chronophysiological action in part by acting through specific membrane receptors (MT1, MT2), which have been identified in SCN cells as well as in several neural and non-neural tissues. Both receptors have been cloned and share general features with other G protein linked receptors. Melatonin also exerts direct effects on intracellular proteins, such as calmodulin or tubulin, has strong free radical scavenger properties, which are non-receptor mediated, is an effective mitochondrial protector and may interact with proteasome to affect intracellular physiology. Within the SCN, melatonin reduces neuronal activity in a time-dependent manner. The disruption of these circadian mechanisms causes a number of sleep disorders known as circadian rhythm sleep disorders (CRSDs). CRSDs include delayed or advanced sleep phase syndromes; non-24 h sleep-wake rhythm disorder, time zone change syndrome (“jet lag”) and shift work sleep disorder. Disturbances in the circadian phase position of plasma melatonin levels have been found in all these disorders. In addition, comorbidity of severe circadian alterations with neurodegenerative diseases like Alzheimer’s disease (AD) has been documented. Currently there is sufficient evidence to implicate endogenous melatonin as an important mediator in CRSD pathophysiology. The documented efficacy of melatonin to reduce chronic benzodiazepine/Z drug use in insomnia patients is also discussed.
Fuente
Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016
Materia
MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/10185

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oai_identifier_str oai:ucacris:123456789/10185
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repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Melatonin signaling as a link between sleep and circadian biology : practical implicationsCardinali, Daniel PedroBrown, Gregory M.MELATONINASUEÑORITMO CIRCADIANOTRASTORNOS DEL SUEÑOBENZODIAZEPINASENFERMEDAD DE ALZHEIMERFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Brown, Gregory M. University of Toronto. Centre for Addiction and Mental Health; CanadáAbstract: Normal circadian rhythms are synchronized to a regular 24 h environmental light-dark cycle. Both the suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation. Melatonin exerts its chronophysiological action in part by acting through specific membrane receptors (MT1, MT2), which have been identified in SCN cells as well as in several neural and non-neural tissues. Both receptors have been cloned and share general features with other G protein linked receptors. Melatonin also exerts direct effects on intracellular proteins, such as calmodulin or tubulin, has strong free radical scavenger properties, which are non-receptor mediated, is an effective mitochondrial protector and may interact with proteasome to affect intracellular physiology. Within the SCN, melatonin reduces neuronal activity in a time-dependent manner. The disruption of these circadian mechanisms causes a number of sleep disorders known as circadian rhythm sleep disorders (CRSDs). CRSDs include delayed or advanced sleep phase syndromes; non-24 h sleep-wake rhythm disorder, time zone change syndrome (“jet lag”) and shift work sleep disorder. Disturbances in the circadian phase position of plasma melatonin levels have been found in all these disorders. In addition, comorbidity of severe circadian alterations with neurodegenerative diseases like Alzheimer’s disease (AD) has been documented. Currently there is sufficient evidence to implicate endogenous melatonin as an important mediator in CRSD pathophysiology. The documented efficacy of melatonin to reduce chronic benzodiazepine/Z drug use in insomnia patients is also discussed.Apple Academic Press2016info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/10185978-1-77188-346-7 (impreso)978-1-77188-347-4 (online)Cardinali, D. P., Brown, G. M. Melatonin signaling as a link between sleep and circadian biology : practical implications [en línea]. En: Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10185Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:57:25Zoai:ucacris:123456789/10185instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:57:25.871Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Melatonin signaling as a link between sleep and circadian biology : practical implications
title Melatonin signaling as a link between sleep and circadian biology : practical implications
spellingShingle Melatonin signaling as a link between sleep and circadian biology : practical implications
Cardinali, Daniel Pedro
MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER
title_short Melatonin signaling as a link between sleep and circadian biology : practical implications
title_full Melatonin signaling as a link between sleep and circadian biology : practical implications
title_fullStr Melatonin signaling as a link between sleep and circadian biology : practical implications
title_full_unstemmed Melatonin signaling as a link between sleep and circadian biology : practical implications
title_sort Melatonin signaling as a link between sleep and circadian biology : practical implications
dc.creator.none.fl_str_mv Cardinali, Daniel Pedro
Brown, Gregory M.
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
Brown, Gregory M.
author_role author
author2 Brown, Gregory M.
author2_role author
dc.subject.none.fl_str_mv MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER
topic MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER
dc.description.none.fl_txt_mv Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brown, Gregory M. University of Toronto. Centre for Addiction and Mental Health; Canadá
Abstract: Normal circadian rhythms are synchronized to a regular 24 h environmental light-dark cycle. Both the suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation. Melatonin exerts its chronophysiological action in part by acting through specific membrane receptors (MT1, MT2), which have been identified in SCN cells as well as in several neural and non-neural tissues. Both receptors have been cloned and share general features with other G protein linked receptors. Melatonin also exerts direct effects on intracellular proteins, such as calmodulin or tubulin, has strong free radical scavenger properties, which are non-receptor mediated, is an effective mitochondrial protector and may interact with proteasome to affect intracellular physiology. Within the SCN, melatonin reduces neuronal activity in a time-dependent manner. The disruption of these circadian mechanisms causes a number of sleep disorders known as circadian rhythm sleep disorders (CRSDs). CRSDs include delayed or advanced sleep phase syndromes; non-24 h sleep-wake rhythm disorder, time zone change syndrome (“jet lag”) and shift work sleep disorder. Disturbances in the circadian phase position of plasma melatonin levels have been found in all these disorders. In addition, comorbidity of severe circadian alterations with neurodegenerative diseases like Alzheimer’s disease (AD) has been documented. Currently there is sufficient evidence to implicate endogenous melatonin as an important mediator in CRSD pathophysiology. The documented efficacy of melatonin to reduce chronic benzodiazepine/Z drug use in insomnia patients is also discussed.
description Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/10185
978-1-77188-346-7 (impreso)
978-1-77188-347-4 (online)
Cardinali, D. P., Brown, G. M. Melatonin signaling as a link between sleep and circadian biology : practical implications [en línea]. En: Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10185
url https://repositorio.uca.edu.ar/handle/123456789/10185
identifier_str_mv 978-1-77188-346-7 (impreso)
978-1-77188-347-4 (online)
Cardinali, D. P., Brown, G. M. Melatonin signaling as a link between sleep and circadian biology : practical implications [en línea]. En: Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10185
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Apple Academic Press
publisher.none.fl_str_mv Apple Academic Press
dc.source.none.fl_str_mv Pandi-Perumal, S. R. (ed.). Synopsis of sleep medicine. Toronto ; New Jersey : Apple Academic Press, 2016
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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