Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease

Autores
Abulafia, Carolina Andrea; Duarte-Abritta, Bárbara; Villareal, Mirta F.; García, Celeste; Sequeyra, Geraldine; Sevlever, Gustavo; Fiorentini, Leticia; Bär, Karl-Jürgen; Gustafson, Deborah R.; Vigo, Daniel Eduardo; Guinjoan, Salvador M.; Ladrón de Guevara, María Soledad
Año de publicación
2017
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Abulafia, Carolina. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Abulafia, Carolina. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada; Argentina
Fil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Duarte-Abritta, Bárbara. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Villareal, Mirta F. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Villareal, Mirta F. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ladrón-de-Guevara, María S. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Ladrón-de-Guevara, María S. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sequeyra, Geraldine. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Sevlever, Gustavo. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Fiorentini, Leticia. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Bär, Karl-Jürgen. Friedrich-Schiller-Universität. Universitätsklinikum Jena. Department of Psychiatry and Psychotherapy; Alemania
Fil: Gustafson, Deborah R. State University of New York. Downstate Medical Center. Department of Neurology; Estados Unidos
Fil: Gustafson, Deborah R. University of Gothenburg. Neuropsychiatric Epidemiology Unit; Suecia
Fil: Gustafson, Deborah R. University of Skövde. Department of Health and Education; Suecia
Fil: Vigo Daniel E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada; Argentina
Fil: Vigo Daniel E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador M. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Fundacion De Altos Estudios Univeristarios Fleni. Unidad Educativa. Departamento de Psiquiatría y Salud Mental; Argentina
Fil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Psicología. Departamento de Neurofisiología; Argentina
Fil: García, Celeste. Fundación De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Abstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer’s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep–wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t D 4.97, df D 49, p < 0.01) and language (Weschler’s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t D 2.49, df D 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t D 2.48, df D 40, p D 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep–wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
Fuente
Frontiers in Aging Neuroscience, Vol. 9, 2017
Materia
ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1463
Acceder
id RIUCA_0748d7c1ed9aac8ed24583f4b67dbcf3
oai_identifier_str oai:ucacris:123456789/1463
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s diseaseAbulafia, Carolina AndreaDuarte-Abritta, BárbaraVillareal, Mirta F.García, CelesteSequeyra, GeraldineSevlever, GustavoFiorentini, LeticiaBär, Karl-JürgenGustafson, Deborah R.Vigo, Daniel EduardoGuinjoan, Salvador M.Ladrón de Guevara, María SoledadENFERMEDAD DE ALZHEIMERPROCESO COGNITIVOSUEÑORITMO CIRCADIANOFil: Abulafia, Carolina. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaFil: Abulafia, Carolina. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada; ArgentinaFil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Duarte-Abritta, Bárbara. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaFil: Villareal, Mirta F. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaFil: Villareal, Mirta F. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ladrón-de-Guevara, María S. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaFil: Ladrón-de-Guevara, María S. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sequeyra, Geraldine. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaFil: Sevlever, Gustavo. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaFil: Fiorentini, Leticia. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaFil: Bär, Karl-Jürgen. Friedrich-Schiller-Universität. Universitätsklinikum Jena. Department of Psychiatry and Psychotherapy; AlemaniaFil: Gustafson, Deborah R. State University of New York. Downstate Medical Center. Department of Neurology; Estados UnidosFil: Gustafson, Deborah R. University of Gothenburg. Neuropsychiatric Epidemiology Unit; SueciaFil: Gustafson, Deborah R. University of Skövde. Department of Health and Education; SueciaFil: Vigo Daniel E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada; ArgentinaFil: Vigo Daniel E. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guinjoan, Salvador M. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaFil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Fundacion De Altos Estudios Univeristarios Fleni. Unidad Educativa. Departamento de Psiquiatría y Salud Mental; ArgentinaFil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Psicología. Departamento de Neurofisiología; ArgentinaFil: García, Celeste. Fundación De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; ArgentinaAbstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer’s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep–wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t D 4.97, df D 49, p < 0.01) and language (Weschler’s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t D 2.49, df D 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t D 2.48, df D 40, p D 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep–wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.Frontiers Media2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/14631663-4365 (online)10.3389/fnagi.2017.00093Abulafia, C., et al. Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease [en línea]. Frontiers in Aging Neuroscience. 2017, 9. doi:10.3389/fnagi.2017.00093. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1463Frontiers in Aging Neuroscience, Vol. 9, 2017reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaspaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:17Zoai:ucacris:123456789/1463instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:17.944Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
spellingShingle Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
Abulafia, Carolina Andrea
ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
title_short Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_full Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_fullStr Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_full_unstemmed Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_sort Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
dc.creator.none.fl_str_mv Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Villareal, Mirta F.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
Ladrón de Guevara, María Soledad
author Abulafia, Carolina Andrea
author_facet Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Villareal, Mirta F.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
Ladrón de Guevara, María Soledad
author_role author
author2 Duarte-Abritta, Bárbara
Villareal, Mirta F.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
Ladrón de Guevara, María Soledad
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
topic ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
dc.description.none.fl_txt_mv Fil: Abulafia, Carolina. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Abulafia, Carolina. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada; Argentina
Fil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Duarte-Abritta, Bárbara. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Villareal, Mirta F. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Villareal, Mirta F. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ladrón-de-Guevara, María S. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Ladrón-de-Guevara, María S. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sequeyra, Geraldine. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Sevlever, Gustavo. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Fiorentini, Leticia. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Bär, Karl-Jürgen. Friedrich-Schiller-Universität. Universitätsklinikum Jena. Department of Psychiatry and Psychotherapy; Alemania
Fil: Gustafson, Deborah R. State University of New York. Downstate Medical Center. Department of Neurology; Estados Unidos
Fil: Gustafson, Deborah R. University of Gothenburg. Neuropsychiatric Epidemiology Unit; Suecia
Fil: Gustafson, Deborah R. University of Skövde. Department of Health and Education; Suecia
Fil: Vigo Daniel E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada; Argentina
Fil: Vigo Daniel E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador M. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Fil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Fundacion De Altos Estudios Univeristarios Fleni. Unidad Educativa. Departamento de Psiquiatría y Salud Mental; Argentina
Fil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Psicología. Departamento de Neurofisiología; Argentina
Fil: García, Celeste. Fundación De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
Abstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer’s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep–wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t D 4.97, df D 49, p < 0.01) and language (Weschler’s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t D 2.49, df D 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t D 2.48, df D 40, p D 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep–wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
description Fil: Abulafia, Carolina. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentina
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1463
1663-4365 (online)
10.3389/fnagi.2017.00093
Abulafia, C., et al. Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease [en línea]. Frontiers in Aging Neuroscience. 2017, 9. doi:10.3389/fnagi.2017.00093. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1463
url https://repositorio.uca.edu.ar/handle/123456789/1463
identifier_str_mv 1663-4365 (online)
10.3389/fnagi.2017.00093
Abulafia, C., et al. Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease [en línea]. Frontiers in Aging Neuroscience. 2017, 9. doi:10.3389/fnagi.2017.00093. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1463
dc.language.none.fl_str_mv spa
eng
language spa
eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Frontiers in Aging Neuroscience, Vol. 9, 2017
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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