TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice

Autores
Phelan, Kevin D.; Shwe, U Thaung; Cozart, Michael A.; Wu, Hong; Mock, Matthew M.; Abramowitz, Joel; Birnbaumer, Lutz; Zheng, Fang
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Phelan, Kevin D. University of Arkansas for Medical Sciences. Department of Neurobiology and Developmental Sciences; Estados Unidos
Fil: Shwe, U Thaung. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Cozart, Michael A. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Wu, Hong. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Mock, Matthew M. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Abramowitz, Joel. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Zheng, Fang. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE).
Fuente
Epilepsia. 2017;58(2):247-254
Materia
ELECTROENCEFALOGRAFIA
NEURONAS
ANALISIS ESPECTRAL
SISTEMA NERVIOSO
MEDICAMENTOS
EPILEPSIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/8738
Acceder
id RIUCA_9fdd8b11e497de610bc8a4659cd2c137
oai_identifier_str oai:ucacris:123456789/8738
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in micePhelan, Kevin D.Shwe, U ThaungCozart, Michael A.Wu, HongMock, Matthew M.Abramowitz, JoelBirnbaumer, LutzZheng, FangELECTROENCEFALOGRAFIANEURONASANALISIS ESPECTRALSISTEMA NERVIOSOMEDICAMENTOSEPILEPSIAFil: Phelan, Kevin D. University of Arkansas for Medical Sciences. Department of Neurobiology and Developmental Sciences; Estados UnidosFil: Shwe, U Thaung. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados UnidosFil: Cozart, Michael A. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados UnidosFil: Wu, Hong. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados UnidosFil: Mock, Matthew M. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados UnidosFil: Abramowitz, Joel. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados UnidosFil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados UnidosFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Zheng, Fang. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados UnidosAbstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE).Wiley2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/87380013-95801528-1167 (online)10.1111/epi.1364828012173Phelan KD, Shwe UT, Cozart MA, et al. TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice [en línea]. Epilepsia. 2017;58(2):247-254. doi:10.1111/epi.13648 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8738Epilepsia. 2017;58(2):247-254reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:54Zoai:ucacris:123456789/8738instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:55.153Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
title TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
spellingShingle TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
Phelan, Kevin D.
ELECTROENCEFALOGRAFIA
NEURONAS
ANALISIS ESPECTRAL
SISTEMA NERVIOSO
MEDICAMENTOS
EPILEPSIA
title_short TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
title_full TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
title_fullStr TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
title_full_unstemmed TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
title_sort TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
dc.creator.none.fl_str_mv Phelan, Kevin D.
Shwe, U Thaung
Cozart, Michael A.
Wu, Hong
Mock, Matthew M.
Abramowitz, Joel
Birnbaumer, Lutz
Zheng, Fang
author Phelan, Kevin D.
author_facet Phelan, Kevin D.
Shwe, U Thaung
Cozart, Michael A.
Wu, Hong
Mock, Matthew M.
Abramowitz, Joel
Birnbaumer, Lutz
Zheng, Fang
author_role author
author2 Shwe, U Thaung
Cozart, Michael A.
Wu, Hong
Mock, Matthew M.
Abramowitz, Joel
Birnbaumer, Lutz
Zheng, Fang
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ELECTROENCEFALOGRAFIA
NEURONAS
ANALISIS ESPECTRAL
SISTEMA NERVIOSO
MEDICAMENTOS
EPILEPSIA
topic ELECTROENCEFALOGRAFIA
NEURONAS
ANALISIS ESPECTRAL
SISTEMA NERVIOSO
MEDICAMENTOS
EPILEPSIA
dc.description.none.fl_txt_mv Fil: Phelan, Kevin D. University of Arkansas for Medical Sciences. Department of Neurobiology and Developmental Sciences; Estados Unidos
Fil: Shwe, U Thaung. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Cozart, Michael A. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Wu, Hong. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Mock, Matthew M. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Abramowitz, Joel. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Zheng, Fang. Universityof Arkansas for Medical Sciences. Department of Pharmacology and Toxicology; Estados Unidos
Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE).
description Fil: Phelan, Kevin D. University of Arkansas for Medical Sciences. Department of Neurobiology and Developmental Sciences; Estados Unidos
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8738
0013-9580
1528-1167 (online)
10.1111/epi.13648
28012173
Phelan KD, Shwe UT, Cozart MA, et al. TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice [en línea]. Epilepsia. 2017;58(2):247-254. doi:10.1111/epi.13648 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8738
url https://repositorio.uca.edu.ar/handle/123456789/8738
identifier_str_mv 0013-9580
1528-1167 (online)
10.1111/epi.13648
28012173
Phelan KD, Shwe UT, Cozart MA, et al. TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice [en línea]. Epilepsia. 2017;58(2):247-254. doi:10.1111/epi.13648 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8738
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Epilepsia. 2017;58(2):247-254
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.069144

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