A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease

Autores
Loureiro, Débora; Bilbao, Rodrigo; Bordet, Sofía; Grasso, Lina; Otero Losada, Matilde; Capani, Francisco; Ponzo, Osvaldo J.; Pérez Lloret, Santiago
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Loureiro, Débora. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Bilbao, Rodrigo. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Bordet, Sofía. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Bordet, Sofía. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Grasso, Lina. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Otero Losada, Matilde. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Capani, Francisco. Universidad Argentina John Kennedy. Departamento de Biología; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Capani, Francisco. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; Chile
Fil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Ponzo, Osvaldo J. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Observatorio de Salud Pública; Argentina
Abstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH with PD-associated Minimal Cognitive Impairment (PD-MCI) and Dementia (PDD) and assess the mitigating effects of potential confounding factors. Methods. Observational studies published in English, Spanish, French, or Portuguese up to January 2022 were searched for in PubMed, EBSCO, and SciELO databases. The primary aim of this study was to revise the association between OH with PD-MCI and PDD. Alongside, we assessed OH as related to cognitive rating scales. Fixed and random models were fitted. Meta-regression was used to assess the mitigating effects of confounding variables. Results. We identified 18 studies that reported OH association with PDD or PD-MCI, 15 of them reporting OH association with cognitive rating scales. OH was significantly associated with PDD/PD-MCI (OR, 95% CI: 3.31, 2.16-5.08; k=18, n=2251; p<0.01). OH association with PDD (4.64, 2.68-8.02; k=13, n=1194; p<0.01) was stronger than with PD-MCI (1.82, 0.92-3.58; k=5, n=1056; p=NS). The association between OH and PD-MCI/PDD was stronger in studies with a higher proportion of women and in those with a lower frequency of supine hypertension. Global cognition rating scale scores were lower in patients with OH (SMD, 95% CI: -0.55, -0.83/-0.26; k= 12, n= 1427; p<0.01). Conclusions. Orthostatic hypotension shows as a significant risk factor for cognitive impairment in PD, especially in women and patients not suffering from hypertension.
Fuente
Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4)
Materia
DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO
Nivel de accesibilidad
acceso embargado
Condiciones de uso
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/16231

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oai_identifier_str oai:ucacris:123456789/16231
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's diseaseLoureiro, DéboraBilbao, RodrigoBordet, SofíaGrasso, LinaOtero Losada, MatildeCapani, FranciscoPonzo, Osvaldo J.Pérez Lloret, SantiagoDETERIORO COGNITIVO LEVEHIPOTENSION ORTOSTATICAHIPERTENSIONENFERMEDAD DE PARKINSONDEMENCIASEXOFil: Loureiro, Débora. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; ArgentinaFil: Bilbao, Rodrigo. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; ArgentinaFil: Bordet, Sofía. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; ArgentinaFil: Bordet, Sofía. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; ArgentinaFil: Grasso, Lina. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; ArgentinaFil: Otero Losada, Matilde. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; ArgentinaFil: Capani, Francisco. Universidad Argentina John Kennedy. Departamento de Biología; ArgentinaFil: Capani, Francisco. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; ArgentinaFil: Capani, Francisco. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; ChileFil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; ArgentinaFil: Ponzo, Osvaldo J. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; ArgentinaFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; ArgentinaFil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Observatorio de Salud Pública; ArgentinaAbstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH with PD-associated Minimal Cognitive Impairment (PD-MCI) and Dementia (PDD) and assess the mitigating effects of potential confounding factors. Methods. Observational studies published in English, Spanish, French, or Portuguese up to January 2022 were searched for in PubMed, EBSCO, and SciELO databases. The primary aim of this study was to revise the association between OH with PD-MCI and PDD. Alongside, we assessed OH as related to cognitive rating scales. Fixed and random models were fitted. Meta-regression was used to assess the mitigating effects of confounding variables. Results. We identified 18 studies that reported OH association with PDD or PD-MCI, 15 of them reporting OH association with cognitive rating scales. OH was significantly associated with PDD/PD-MCI (OR, 95% CI: 3.31, 2.16-5.08; k=18, n=2251; p<0.01). OH association with PDD (4.64, 2.68-8.02; k=13, n=1194; p<0.01) was stronger than with PD-MCI (1.82, 0.92-3.58; k=5, n=1056; p=NS). The association between OH and PD-MCI/PDD was stronger in studies with a higher proportion of women and in those with a lower frequency of supine hypertension. Global cognition rating scale scores were lower in patients with OH (SMD, 95% CI: -0.55, -0.83/-0.26; k= 12, n= 1427; p<0.01). Conclusions. Orthostatic hypotension shows as a significant risk factor for cognitive impairment in PD, especially in women and patients not suffering from hypertension.Springerinfo:eu-repo/date/embargoEnd/2024-04-012023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/162311590-1874 (impreso)1590-3478 (online)10.1007/s10072-022-06537-3Pérez Lloret, S. et al. A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease [en línea]. Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4). doi: 10.1007/s10072-022-06537-3. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16231Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/embargoedAccess2025-07-03T10:59:13Zoai:ucacris:123456789/16231instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:13.616Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
spellingShingle A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
Loureiro, Débora
DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO
title_short A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_full A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_fullStr A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_full_unstemmed A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_sort A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
dc.creator.none.fl_str_mv Loureiro, Débora
Bilbao, Rodrigo
Bordet, Sofía
Grasso, Lina
Otero Losada, Matilde
Capani, Francisco
Ponzo, Osvaldo J.
Pérez Lloret, Santiago
author Loureiro, Débora
author_facet Loureiro, Débora
Bilbao, Rodrigo
Bordet, Sofía
Grasso, Lina
Otero Losada, Matilde
Capani, Francisco
Ponzo, Osvaldo J.
Pérez Lloret, Santiago
author_role author
author2 Bilbao, Rodrigo
Bordet, Sofía
Grasso, Lina
Otero Losada, Matilde
Capani, Francisco
Ponzo, Osvaldo J.
Pérez Lloret, Santiago
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO
topic DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO
dc.description.none.fl_txt_mv Fil: Loureiro, Débora. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Bilbao, Rodrigo. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Bordet, Sofía. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Bordet, Sofía. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Grasso, Lina. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Otero Losada, Matilde. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Capani, Francisco. Universidad Argentina John Kennedy. Departamento de Biología; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Capani, Francisco. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; Chile
Fil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Ponzo, Osvaldo J. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Observatorio de Salud Pública; Argentina
Abstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH with PD-associated Minimal Cognitive Impairment (PD-MCI) and Dementia (PDD) and assess the mitigating effects of potential confounding factors. Methods. Observational studies published in English, Spanish, French, or Portuguese up to January 2022 were searched for in PubMed, EBSCO, and SciELO databases. The primary aim of this study was to revise the association between OH with PD-MCI and PDD. Alongside, we assessed OH as related to cognitive rating scales. Fixed and random models were fitted. Meta-regression was used to assess the mitigating effects of confounding variables. Results. We identified 18 studies that reported OH association with PDD or PD-MCI, 15 of them reporting OH association with cognitive rating scales. OH was significantly associated with PDD/PD-MCI (OR, 95% CI: 3.31, 2.16-5.08; k=18, n=2251; p<0.01). OH association with PDD (4.64, 2.68-8.02; k=13, n=1194; p<0.01) was stronger than with PD-MCI (1.82, 0.92-3.58; k=5, n=1056; p=NS). The association between OH and PD-MCI/PDD was stronger in studies with a higher proportion of women and in those with a lower frequency of supine hypertension. Global cognition rating scale scores were lower in patients with OH (SMD, 95% CI: -0.55, -0.83/-0.26; k= 12, n= 1427; p<0.01). Conclusions. Orthostatic hypotension shows as a significant risk factor for cognitive impairment in PD, especially in women and patients not suffering from hypertension.
description Fil: Loureiro, Débora. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
publishDate 2023
dc.date.none.fl_str_mv 2023
info:eu-repo/date/embargoEnd/2024-04-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/16231
1590-1874 (impreso)
1590-3478 (online)
10.1007/s10072-022-06537-3
Pérez Lloret, S. et al. A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease [en línea]. Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4). doi: 10.1007/s10072-022-06537-3. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16231
url https://repositorio.uca.edu.ar/handle/123456789/16231
identifier_str_mv 1590-1874 (impreso)
1590-3478 (online)
10.1007/s10072-022-06537-3
Pérez Lloret, S. et al. A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease [en línea]. Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4). doi: 10.1007/s10072-022-06537-3. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16231
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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