A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
- Autores
- Loureiro, Débora; Bilbao, Rodrigo; Bordet, Sofía; Grasso, Lina; Otero Losada, Matilde; Capani, Francisco; Ponzo, Osvaldo J.; Pérez Lloret, Santiago
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Loureiro, Débora. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Bilbao, Rodrigo. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Bordet, Sofía. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Bordet, Sofía. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Grasso, Lina. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Otero Losada, Matilde. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Capani, Francisco. Universidad Argentina John Kennedy. Departamento de Biología; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina
Fil: Capani, Francisco. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; Chile
Fil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Ponzo, Osvaldo J. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Observatorio de Salud Pública; Argentina
Abstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH with PD-associated Minimal Cognitive Impairment (PD-MCI) and Dementia (PDD) and assess the mitigating effects of potential confounding factors. Methods. Observational studies published in English, Spanish, French, or Portuguese up to January 2022 were searched for in PubMed, EBSCO, and SciELO databases. The primary aim of this study was to revise the association between OH with PD-MCI and PDD. Alongside, we assessed OH as related to cognitive rating scales. Fixed and random models were fitted. Meta-regression was used to assess the mitigating effects of confounding variables. Results. We identified 18 studies that reported OH association with PDD or PD-MCI, 15 of them reporting OH association with cognitive rating scales. OH was significantly associated with PDD/PD-MCI (OR, 95% CI: 3.31, 2.16-5.08; k=18, n=2251; p<0.01). OH association with PDD (4.64, 2.68-8.02; k=13, n=1194; p<0.01) was stronger than with PD-MCI (1.82, 0.92-3.58; k=5, n=1056; p=NS). The association between OH and PD-MCI/PDD was stronger in studies with a higher proportion of women and in those with a lower frequency of supine hypertension. Global cognition rating scale scores were lower in patients with OH (SMD, 95% CI: -0.55, -0.83/-0.26; k= 12, n= 1427; p<0.01). Conclusions. Orthostatic hypotension shows as a significant risk factor for cognitive impairment in PD, especially in women and patients not suffering from hypertension. - Fuente
- Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4)
- Materia
-
DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO - Nivel de accesibilidad
- acceso embargado
- Condiciones de uso
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/16231
Ver los metadatos del registro completo
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A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's diseaseLoureiro, DéboraBilbao, RodrigoBordet, SofíaGrasso, LinaOtero Losada, MatildeCapani, FranciscoPonzo, Osvaldo J.Pérez Lloret, SantiagoDETERIORO COGNITIVO LEVEHIPOTENSION ORTOSTATICAHIPERTENSIONENFERMEDAD DE PARKINSONDEMENCIASEXOFil: Loureiro, Débora. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; ArgentinaFil: Bilbao, Rodrigo. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; ArgentinaFil: Bordet, Sofía. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; ArgentinaFil: Bordet, Sofía. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; ArgentinaFil: Grasso, Lina. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; ArgentinaFil: Otero Losada, Matilde. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; ArgentinaFil: Capani, Francisco. Universidad Argentina John Kennedy. Departamento de Biología; ArgentinaFil: Capani, Francisco. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; ArgentinaFil: Capani, Francisco. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; ChileFil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; ArgentinaFil: Ponzo, Osvaldo J. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; ArgentinaFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; ArgentinaFil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Observatorio de Salud Pública; ArgentinaAbstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH with PD-associated Minimal Cognitive Impairment (PD-MCI) and Dementia (PDD) and assess the mitigating effects of potential confounding factors. Methods. Observational studies published in English, Spanish, French, or Portuguese up to January 2022 were searched for in PubMed, EBSCO, and SciELO databases. The primary aim of this study was to revise the association between OH with PD-MCI and PDD. Alongside, we assessed OH as related to cognitive rating scales. Fixed and random models were fitted. Meta-regression was used to assess the mitigating effects of confounding variables. Results. We identified 18 studies that reported OH association with PDD or PD-MCI, 15 of them reporting OH association with cognitive rating scales. OH was significantly associated with PDD/PD-MCI (OR, 95% CI: 3.31, 2.16-5.08; k=18, n=2251; p<0.01). OH association with PDD (4.64, 2.68-8.02; k=13, n=1194; p<0.01) was stronger than with PD-MCI (1.82, 0.92-3.58; k=5, n=1056; p=NS). The association between OH and PD-MCI/PDD was stronger in studies with a higher proportion of women and in those with a lower frequency of supine hypertension. Global cognition rating scale scores were lower in patients with OH (SMD, 95% CI: -0.55, -0.83/-0.26; k= 12, n= 1427; p<0.01). Conclusions. Orthostatic hypotension shows as a significant risk factor for cognitive impairment in PD, especially in women and patients not suffering from hypertension.Springerinfo:eu-repo/date/embargoEnd/2024-04-012023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/162311590-1874 (impreso)1590-3478 (online)10.1007/s10072-022-06537-3Pérez Lloret, S. et al. A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease [en línea]. Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4). doi: 10.1007/s10072-022-06537-3. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16231Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/embargoedAccess2025-07-03T10:59:13Zoai:ucacris:123456789/16231instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:13.616Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease |
title |
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease |
spellingShingle |
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease Loureiro, Débora DETERIORO COGNITIVO LEVE HIPOTENSION ORTOSTATICA HIPERTENSION ENFERMEDAD DE PARKINSON DEMENCIA SEXO |
title_short |
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease |
title_full |
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease |
title_fullStr |
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease |
title_full_unstemmed |
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease |
title_sort |
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease |
dc.creator.none.fl_str_mv |
Loureiro, Débora Bilbao, Rodrigo Bordet, Sofía Grasso, Lina Otero Losada, Matilde Capani, Francisco Ponzo, Osvaldo J. Pérez Lloret, Santiago |
author |
Loureiro, Débora |
author_facet |
Loureiro, Débora Bilbao, Rodrigo Bordet, Sofía Grasso, Lina Otero Losada, Matilde Capani, Francisco Ponzo, Osvaldo J. Pérez Lloret, Santiago |
author_role |
author |
author2 |
Bilbao, Rodrigo Bordet, Sofía Grasso, Lina Otero Losada, Matilde Capani, Francisco Ponzo, Osvaldo J. Pérez Lloret, Santiago |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
DETERIORO COGNITIVO LEVE HIPOTENSION ORTOSTATICA HIPERTENSION ENFERMEDAD DE PARKINSON DEMENCIA SEXO |
topic |
DETERIORO COGNITIVO LEVE HIPOTENSION ORTOSTATICA HIPERTENSION ENFERMEDAD DE PARKINSON DEMENCIA SEXO |
dc.description.none.fl_txt_mv |
Fil: Loureiro, Débora. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina Fil: Bilbao, Rodrigo. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina Fil: Bordet, Sofía. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina Fil: Bordet, Sofía. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina Fil: Grasso, Lina. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina Fil: Otero Losada, Matilde. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina Fil: Capani, Francisco. Universidad Argentina John Kennedy. Departamento de Biología; Argentina Fil: Capani, Francisco. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina Fil: Capani, Francisco. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; Chile Fil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina Fil: Ponzo, Osvaldo J. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Observatorio de Salud Pública; Argentina Abstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH with PD-associated Minimal Cognitive Impairment (PD-MCI) and Dementia (PDD) and assess the mitigating effects of potential confounding factors. Methods. Observational studies published in English, Spanish, French, or Portuguese up to January 2022 were searched for in PubMed, EBSCO, and SciELO databases. The primary aim of this study was to revise the association between OH with PD-MCI and PDD. Alongside, we assessed OH as related to cognitive rating scales. Fixed and random models were fitted. Meta-regression was used to assess the mitigating effects of confounding variables. Results. We identified 18 studies that reported OH association with PDD or PD-MCI, 15 of them reporting OH association with cognitive rating scales. OH was significantly associated with PDD/PD-MCI (OR, 95% CI: 3.31, 2.16-5.08; k=18, n=2251; p<0.01). OH association with PDD (4.64, 2.68-8.02; k=13, n=1194; p<0.01) was stronger than with PD-MCI (1.82, 0.92-3.58; k=5, n=1056; p=NS). The association between OH and PD-MCI/PDD was stronger in studies with a higher proportion of women and in those with a lower frequency of supine hypertension. Global cognition rating scale scores were lower in patients with OH (SMD, 95% CI: -0.55, -0.83/-0.26; k= 12, n= 1427; p<0.01). Conclusions. Orthostatic hypotension shows as a significant risk factor for cognitive impairment in PD, especially in women and patients not suffering from hypertension. |
description |
Fil: Loureiro, Débora. Universidad de Buenos Aires. Facultad de Ciencias Médicas. Departamento de Fisiología; Argentina |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 info:eu-repo/date/embargoEnd/2024-04-01 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/16231 1590-1874 (impreso) 1590-3478 (online) 10.1007/s10072-022-06537-3 Pérez Lloret, S. et al. A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease [en línea]. Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4). doi: 10.1007/s10072-022-06537-3. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16231 |
url |
https://repositorio.uca.edu.ar/handle/123456789/16231 |
identifier_str_mv |
1590-1874 (impreso) 1590-3478 (online) 10.1007/s10072-022-06537-3 Pérez Lloret, S. et al. A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease [en línea]. Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4). doi: 10.1007/s10072-022-06537-3. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16231 |
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eng |
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eng |
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Springer |
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Springer |
dc.source.none.fl_str_mv |
Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4) reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
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Repositorio Institucional (UCA) |
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Pontificia Universidad Católica Argentina |
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Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
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claudia_fernandez@uca.edu.ar |
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