Clinical aspects of melatonin intervention in Alzheimer's disease progression
- Autores
- Cardinali, Daniel Pedro; Furio, Analía M.; Brusco, Luis I.
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Cardinali, Daniel P. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Furio, Analía M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Furio, Analía M. Universidad de Buenos Aires. Hospital de Clínicas José de San Martín; Argentina
Fil: Brusco, Luis I. Universidad de Buenos Aires. Hospital de Clínicas José de San Martín; Argentina
Abstract: Melatonin secretion decreases in Alzheimer´s disease (AD) and this decrease has been postulated as responsible for the circadian disorganization, decrease in sleep efficiency and impaired cognitive function seen in those patients. Half of severely ill AD patients develop chronobiological day‐night rhythm disturbances like an agitated behavior during the evening hours (so‐called “sundowning”). Melatonin replacement has been shown effective to treat sundowning and other sleep wake disorders in AD patients. The antioxidant, mitochondrial and antiamyloidogenic effects of melatonin indicate its potentiality to interfere with the onset of the disease. This is of particularly importance in mild cognitive impairment (MCI), an etiologically heterogeneous syndrome that precedes dementia. The aim of this manuscript was to assess published evidence of the efficacy of melatonin to treat AD and MCI patients. PubMed was searched using Entrez for articles including clinical trials and published up to 15 January 2010. Search terms were “Alzheimer” and “melatonin”. Full publications were obtained and references were checked for additional material where appropriate. Only clinical studies with empirical treatment data were reviewed. The analysis of published evidence made it possible to postulate melatonin as a useful ad‐on therapeutic tool in MCI. In the case of AD, larger randomized controlled trials are necessary to yield evidence of effectiveness (i.e. clinical and subjective relevance) before melatonin´s use can be advocated. - Fuente
- Current Neuropharmacology. 2010, 8 (3)
- Materia
-
MELATONINA
ENFERMEDAD DE ALZHEIMER
ENSAYO CLINICO
RITMO CIRCADIANO
PRUEBAS NEUROPSICOLOGICAS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/1625
Ver los metadatos del registro completo
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Clinical aspects of melatonin intervention in Alzheimer's disease progressionCardinali, Daniel PedroFurio, Analía M.Brusco, Luis I.MELATONINAENFERMEDAD DE ALZHEIMERENSAYO CLINICORITMO CIRCADIANOPRUEBAS NEUROPSICOLOGICASFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Cardinali, Daniel P. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; ArgentinaFil: Furio, Analía M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; ArgentinaFil: Furio, Analía M. Universidad de Buenos Aires. Hospital de Clínicas José de San Martín; ArgentinaFil: Brusco, Luis I. Universidad de Buenos Aires. Hospital de Clínicas José de San Martín; ArgentinaAbstract: Melatonin secretion decreases in Alzheimer´s disease (AD) and this decrease has been postulated as responsible for the circadian disorganization, decrease in sleep efficiency and impaired cognitive function seen in those patients. Half of severely ill AD patients develop chronobiological day‐night rhythm disturbances like an agitated behavior during the evening hours (so‐called “sundowning”). Melatonin replacement has been shown effective to treat sundowning and other sleep wake disorders in AD patients. The antioxidant, mitochondrial and antiamyloidogenic effects of melatonin indicate its potentiality to interfere with the onset of the disease. This is of particularly importance in mild cognitive impairment (MCI), an etiologically heterogeneous syndrome that precedes dementia. The aim of this manuscript was to assess published evidence of the efficacy of melatonin to treat AD and MCI patients. PubMed was searched using Entrez for articles including clinical trials and published up to 15 January 2010. Search terms were “Alzheimer” and “melatonin”. Full publications were obtained and references were checked for additional material where appropriate. Only clinical studies with empirical treatment data were reviewed. The analysis of published evidence made it possible to postulate melatonin as a useful ad‐on therapeutic tool in MCI. In the case of AD, larger randomized controlled trials are necessary to yield evidence of effectiveness (i.e. clinical and subjective relevance) before melatonin´s use can be advocated.Bentham Science Publishers2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16251570-159X (impreso)1875-6190 (online)10.2174/157015910792246209Cardinali, D. P., Furio, A. M., Brusco, L. I. Clinical aspects of melatonin intervention in Alzheimer's disease progression [en línea]. Current Neuropharmacology. 2010, 8 (3). doi:10.2174/157015910792246209. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1625Current Neuropharmacology. 2010, 8 (3)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:19Zoai:ucacris:123456789/1625instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:20.006Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Clinical aspects of melatonin intervention in Alzheimer's disease progression |
title |
Clinical aspects of melatonin intervention in Alzheimer's disease progression |
spellingShingle |
Clinical aspects of melatonin intervention in Alzheimer's disease progression Cardinali, Daniel Pedro MELATONINA ENFERMEDAD DE ALZHEIMER ENSAYO CLINICO RITMO CIRCADIANO PRUEBAS NEUROPSICOLOGICAS |
title_short |
Clinical aspects of melatonin intervention in Alzheimer's disease progression |
title_full |
Clinical aspects of melatonin intervention in Alzheimer's disease progression |
title_fullStr |
Clinical aspects of melatonin intervention in Alzheimer's disease progression |
title_full_unstemmed |
Clinical aspects of melatonin intervention in Alzheimer's disease progression |
title_sort |
Clinical aspects of melatonin intervention in Alzheimer's disease progression |
dc.creator.none.fl_str_mv |
Cardinali, Daniel Pedro Furio, Analía M. Brusco, Luis I. |
author |
Cardinali, Daniel Pedro |
author_facet |
Cardinali, Daniel Pedro Furio, Analía M. Brusco, Luis I. |
author_role |
author |
author2 |
Furio, Analía M. Brusco, Luis I. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
MELATONINA ENFERMEDAD DE ALZHEIMER ENSAYO CLINICO RITMO CIRCADIANO PRUEBAS NEUROPSICOLOGICAS |
topic |
MELATONINA ENFERMEDAD DE ALZHEIMER ENSAYO CLINICO RITMO CIRCADIANO PRUEBAS NEUROPSICOLOGICAS |
dc.description.none.fl_txt_mv |
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina Fil: Cardinali, Daniel P. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina Fil: Furio, Analía M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina Fil: Furio, Analía M. Universidad de Buenos Aires. Hospital de Clínicas José de San Martín; Argentina Fil: Brusco, Luis I. Universidad de Buenos Aires. Hospital de Clínicas José de San Martín; Argentina Abstract: Melatonin secretion decreases in Alzheimer´s disease (AD) and this decrease has been postulated as responsible for the circadian disorganization, decrease in sleep efficiency and impaired cognitive function seen in those patients. Half of severely ill AD patients develop chronobiological day‐night rhythm disturbances like an agitated behavior during the evening hours (so‐called “sundowning”). Melatonin replacement has been shown effective to treat sundowning and other sleep wake disorders in AD patients. The antioxidant, mitochondrial and antiamyloidogenic effects of melatonin indicate its potentiality to interfere with the onset of the disease. This is of particularly importance in mild cognitive impairment (MCI), an etiologically heterogeneous syndrome that precedes dementia. The aim of this manuscript was to assess published evidence of the efficacy of melatonin to treat AD and MCI patients. PubMed was searched using Entrez for articles including clinical trials and published up to 15 January 2010. Search terms were “Alzheimer” and “melatonin”. Full publications were obtained and references were checked for additional material where appropriate. Only clinical studies with empirical treatment data were reviewed. The analysis of published evidence made it possible to postulate melatonin as a useful ad‐on therapeutic tool in MCI. In the case of AD, larger randomized controlled trials are necessary to yield evidence of effectiveness (i.e. clinical and subjective relevance) before melatonin´s use can be advocated. |
description |
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/1625 1570-159X (impreso) 1875-6190 (online) 10.2174/157015910792246209 Cardinali, D. P., Furio, A. M., Brusco, L. I. Clinical aspects of melatonin intervention in Alzheimer's disease progression [en línea]. Current Neuropharmacology. 2010, 8 (3). doi:10.2174/157015910792246209. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1625 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1625 |
identifier_str_mv |
1570-159X (impreso) 1875-6190 (online) 10.2174/157015910792246209 Cardinali, D. P., Furio, A. M., Brusco, L. I. Clinical aspects of melatonin intervention in Alzheimer's disease progression [en línea]. Current Neuropharmacology. 2010, 8 (3). doi:10.2174/157015910792246209. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1625 |
dc.language.none.fl_str_mv |
eng eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Bentham Science Publishers |
publisher.none.fl_str_mv |
Bentham Science Publishers |
dc.source.none.fl_str_mv |
Current Neuropharmacology. 2010, 8 (3) reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638330562805760 |
score |
13.13397 |