Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice

Autores
Acosta, Julieta; Crespo, Manuel T.; Plano, Santiago Andrés; Golombek, Diego A.; Chiesa, Juan José; Agostino, Patricia V.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Acosta, Julieta. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Acosta, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Crespo, Manuel T. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Crespo, Manuel T. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Plano, Santiago Andrés. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Plano, Santiago Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego A. Universidad de San Andrés. Laboratorio Interdisciplinario del Tiempo y la Experiencia en la República Argentina; Argentina
Fil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Chiesa, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Agostino, Patricia V. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Agostino, Patricia V. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.
Fuente
Acosta, J. et al. Chronic jet lag reduces motivation and affects other moodrelated behaviors in male mice. Frontiers in Physiology. 2023, 14:1225134
Materia
RITMO CIRCADIANO
SUEÑO
TRASTORNOS DEL SUEÑO
DEPRESION
TRASTONOS CRONOBIOLOGICOS
ESTADO DE ANIMO
MOTIVACION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/17438
Acceder
id RIUCA_6e1f10bac0fa318a660848f4d0c21557
oai_identifier_str oai:ucacris:123456789/17438
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Chronic jet lag reduces motivation and affects other mood-related behaviors in male miceAcosta, JulietaCrespo, Manuel T.Plano, Santiago AndrésGolombek, Diego A.Chiesa, Juan JoséAgostino, Patricia V.RITMO CIRCADIANOSUEÑOTRASTORNOS DEL SUEÑODEPRESIONTRASTONOS CRONOBIOLOGICOSESTADO DE ANIMOMOTIVACIONFil: Acosta, Julieta. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Acosta, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Crespo, Manuel T. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Crespo, Manuel T. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Plano, Santiago Andrés. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Plano, Santiago Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego A. Universidad de San Andrés. Laboratorio Interdisciplinario del Tiempo y la Experiencia en la República Argentina; ArgentinaFil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Chiesa, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Agostino, Patricia V. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Agostino, Patricia V. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.Frontiers Media2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/174381664-042X10.3389/fphys.2023.122513437745237Acosta, J., Crespo, M. T., Plano, S. A., Golombek, D. A., Chiesa, J. J., Agostino, P. V. Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice [en línea]. En: Acosta, J. et al. Chronic jet lag reduces motivation and affects other moodrelated behaviors in male mice. Frontiers in Physiology. 2023, 14:1225134. doi: 10.3389/fphys.2023.1225134. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17438Acosta, J. et al. Chronic jet lag reduces motivation and affects other moodrelated behaviors in male mice. Frontiers in Physiology. 2023, 14:1225134reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:59:35Zoai:ucacris:123456789/17438instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:36.096Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
spellingShingle Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
Acosta, Julieta
RITMO CIRCADIANO
SUEÑO
TRASTORNOS DEL SUEÑO
DEPRESION
TRASTONOS CRONOBIOLOGICOS
ESTADO DE ANIMO
MOTIVACION
title_short Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_full Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_fullStr Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_full_unstemmed Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_sort Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
dc.creator.none.fl_str_mv Acosta, Julieta
Crespo, Manuel T.
Plano, Santiago Andrés
Golombek, Diego A.
Chiesa, Juan José
Agostino, Patricia V.
author Acosta, Julieta
author_facet Acosta, Julieta
Crespo, Manuel T.
Plano, Santiago Andrés
Golombek, Diego A.
Chiesa, Juan José
Agostino, Patricia V.
author_role author
author2 Crespo, Manuel T.
Plano, Santiago Andrés
Golombek, Diego A.
Chiesa, Juan José
Agostino, Patricia V.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv RITMO CIRCADIANO
SUEÑO
TRASTORNOS DEL SUEÑO
DEPRESION
TRASTONOS CRONOBIOLOGICOS
ESTADO DE ANIMO
MOTIVACION
topic RITMO CIRCADIANO
SUEÑO
TRASTORNOS DEL SUEÑO
DEPRESION
TRASTONOS CRONOBIOLOGICOS
ESTADO DE ANIMO
MOTIVACION
dc.description.none.fl_txt_mv Fil: Acosta, Julieta. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Acosta, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Crespo, Manuel T. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Crespo, Manuel T. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Plano, Santiago Andrés. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Plano, Santiago Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego A. Universidad de San Andrés. Laboratorio Interdisciplinario del Tiempo y la Experiencia en la República Argentina; Argentina
Fil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Chiesa, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Agostino, Patricia V. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Agostino, Patricia V. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.
description Fil: Acosta, Julieta. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/17438
1664-042X
10.3389/fphys.2023.1225134
37745237
Acosta, J., Crespo, M. T., Plano, S. A., Golombek, D. A., Chiesa, J. J., Agostino, P. V. Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice [en línea]. En: Acosta, J. et al. Chronic jet lag reduces motivation and affects other moodrelated behaviors in male mice. Frontiers in Physiology. 2023, 14:1225134. doi: 10.3389/fphys.2023.1225134. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17438
url https://repositorio.uca.edu.ar/handle/123456789/17438
identifier_str_mv 1664-042X
10.3389/fphys.2023.1225134
37745237
Acosta, J., Crespo, M. T., Plano, S. A., Golombek, D. A., Chiesa, J. J., Agostino, P. V. Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice [en línea]. En: Acosta, J. et al. Chronic jet lag reduces motivation and affects other moodrelated behaviors in male mice. Frontiers in Physiology. 2023, 14:1225134. doi: 10.3389/fphys.2023.1225134. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17438
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Acosta, J. et al. Chronic jet lag reduces motivation and affects other moodrelated behaviors in male mice. Frontiers in Physiology. 2023, 14:1225134
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
_version_ 1836638371421618176
score 13.13397

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