Jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs

• Autores: Srinivasan, Venkataramanujan; Singh, Jarnail; Pandi Perumal, Seithikurippu R.; Spence, David Warren; Brown, Gregory M.; Cardinali, Daniel Pedro
• Año de publicación: 2010
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Advances in Therapy. (2010), 27 (11)
• Materia: RITMO CIRCADIANO; DEPRESION; MELATONINA; INSOMNIO; FATIGA; TRASTORNOS DEL SUEÑO; RAMELTEON; TASIMELTEON; TRASTONOS CRONOBIOLOGICOS
• Institución: Pontificia Universidad Católica Argentina

Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India
Fil: Srinivasan, Venkataramanujan. Karpagam University. Facultad de Medicina. Departamento de Fisiología; India
Fil: Singh, Jarnail. Civil Aviation Authority; Singapur
Fil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados Unidos
Fil: Spence, David Warren. Sleep and Alertness Clinic; Estados Unidos
Fil: Brown, Gregory M. Centre for Addiction and Mental Health; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Abstract: Travelling through several time zones results in a constellation of symptoms known as jet lag. These include reduced alertness, daytime fatigue, loss of appetite, reduced cognitive skills, and disruptions to sleep/wakefulness and other circadian rhythms. In susceptible air travel passengers, jet lag may exacerbate affective illness ans result in psychiatric morbidity. It is suggested that dysregulation of circadian rhythms and melatonin secretion represents the common underlying factor in jet lag and other circadian disorders. Hence the effective management of jet lag requires timely application of the well known chronobiotic melatonin. Recent studies have emphasized the importance of strategically timed administrations of melatonin and appropriate limited exposure to environmental schedules. However, with the introduction of the melatonergic agonists such as ramelteon and tasimelteon, which have both a strong affinity for MT1 and MT2 melatonin receptors and a longer half life, a new therapeutic option now exists for treating the sleep disturbances associated with jet lag. The melatonin analogs are unique inasmuch as they can also enhance daytime alertness. Since jet lag exacerbates affective disorders in susceptible air‐travel passengers, and can thus produce psychiatric morbidity, there is a need for an effective antidepressant with chronobiotic properties. In this regard the recently introduced melatonergic antidepressant agomelatine, which has successfully established its supremacy over other antidepressants in having chronobiotic effects, represents a good choice for treating depressive symptoms that are associated with jet lag.