Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice

Autores
Acosta, Julieta; Crespo, Manuel Tomas; Plano, Santiago Andrés; Golombek, Diego Andrés; Chiesa, Juan José; Agostino, Patricia
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.
Fil: Acosta, Julieta. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Crespo, Manuel Tomas. Universidad Nacional de Quilmes; Argentina
Fil: Plano, Santiago Andrés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Golombek, Diego Andrés. Universidad de San Andrés. Escuela de Educación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Chiesa, Juan José. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Agostino, Patricia. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CHRONIC JET LAG
CIRCADIAN SYSTEM
DEPRESSION
MOOD-RELATED BEHAVIORS
MOTIVATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227610
Acceder
id CONICETDig_0cde5006db0fcecbdde21d5dfea39957
oai_identifier_str oai:ri.conicet.gov.ar:11336/227610
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chronic jet lag reduces motivation and affects other mood-related behaviors in male miceAcosta, JulietaCrespo, Manuel TomasPlano, Santiago AndrésGolombek, Diego AndrésChiesa, Juan JoséAgostino, PatriciaCHRONIC JET LAGCIRCADIAN SYSTEMDEPRESSIONMOOD-RELATED BEHAVIORSMOTIVATIONhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.Fil: Acosta, Julieta. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Crespo, Manuel Tomas. Universidad Nacional de Quilmes; ArgentinaFil: Plano, Santiago Andrés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Golombek, Diego Andrés. Universidad de San Andrés. Escuela de Educación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Chiesa, Juan José. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Agostino, Patricia. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers Media2023-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227610Acosta, Julieta; Crespo, Manuel Tomas; Plano, Santiago Andrés; Golombek, Diego Andrés; Chiesa, Juan José; et al.; Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice; Frontiers Media; Frontiers in Physiology; 14; 8-2023; 1-101664-042XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2023.1225134/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2023.1225134info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:21:15Zoai:ri.conicet.gov.ar:11336/227610instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:21:16.142CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
spellingShingle Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
Acosta, Julieta
CHRONIC JET LAG
CIRCADIAN SYSTEM
DEPRESSION
MOOD-RELATED BEHAVIORS
MOTIVATION
title_short Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_full Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_fullStr Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_full_unstemmed Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_sort Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
dc.creator.none.fl_str_mv Acosta, Julieta
Crespo, Manuel Tomas
Plano, Santiago Andrés
Golombek, Diego Andrés
Chiesa, Juan José
Agostino, Patricia
author Acosta, Julieta
author_facet Acosta, Julieta
Crespo, Manuel Tomas
Plano, Santiago Andrés
Golombek, Diego Andrés
Chiesa, Juan José
Agostino, Patricia
author_role author
author2 Crespo, Manuel Tomas
Plano, Santiago Andrés
Golombek, Diego Andrés
Chiesa, Juan José
Agostino, Patricia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHRONIC JET LAG
CIRCADIAN SYSTEM
DEPRESSION
MOOD-RELATED BEHAVIORS
MOTIVATION
topic CHRONIC JET LAG
CIRCADIAN SYSTEM
DEPRESSION
MOOD-RELATED BEHAVIORS
MOTIVATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.
Fil: Acosta, Julieta. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Crespo, Manuel Tomas. Universidad Nacional de Quilmes; Argentina
Fil: Plano, Santiago Andrés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Golombek, Diego Andrés. Universidad de San Andrés. Escuela de Educación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Chiesa, Juan José. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Agostino, Patricia. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.
publishDate 2023
dc.date.none.fl_str_mv 2023-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227610
Acosta, Julieta; Crespo, Manuel Tomas; Plano, Santiago Andrés; Golombek, Diego Andrés; Chiesa, Juan José; et al.; Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice; Frontiers Media; Frontiers in Physiology; 14; 8-2023; 1-10
1664-042X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227610
identifier_str_mv Acosta, Julieta; Crespo, Manuel Tomas; Plano, Santiago Andrés; Golombek, Diego Andrés; Chiesa, Juan José; et al.; Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice; Frontiers Media; Frontiers in Physiology; 14; 8-2023; 1-10
1664-042X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2023.1225134/abstract
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2023.1225134
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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