Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease

• Autores: Duarte-Abritta, Bárbara; Villareal, Mirta F.; Abulafia, Carolina Andrea; Loewenstein, David A.; Curiel-Cid, Rosie; Castro, Mariana N.; Surace, Ezequiel; Sánchez, Stella M.; Vigo, Daniel Eduardo; Vázquez, Silvia; Nemeroff, Charles B.; Sevlever, Gustavo; Guinjoan, Salvador M.
• Año de publicación: 2018
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Postprint del artículo publicado en Journal of Psychiatric Research, Vol. 107, 2018
• Materia: MEDICINA; ENFERMEDAD DE ALZHEIMER; CEREBRO; BIOMEDICINA
• Institución: Pontificia Universidad Católica Argentina

Fil: Duarte-Abritta, Bárbara. Fundación FLENI. Servicio de Psiquiatría; Argentina
Fil: Villareal, Mirta F. Fundación FLENI. Servicio de Psiquiatría; Argentina
Fil: Villarealm, Mirta F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Abulafia, Carolina. Fundación FLENI. Servicio de Psiquiatría; Argentina
Fil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Abulafia, Carolina. Pontificia Universidad Católica Argentina. Facultad de Ciencas Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Loewenstein, David A. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados Unidos
Fil: Curiel-Cid, Rosie. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados Unidos
Fil: Castro, Mariana N. Fundación FLENI. Servicio de Psiquiatría; Argentina
Fil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina
Fil: Surace, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Surace, Ezequiel. Fundacion FLENI. Departamento de Neuropatología y Biología Molecular; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Tecnicas; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencas Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vázquez, Silvia. Fundación FLENI. Centro de Imágenes Moleculares; Argentina
Fil: Nemeroff, Charles B. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados Unidos
Fil: Sevlever, Gustavo. Fundacion FLENI. Departamento de Neuropatología y Biología Molecular; Argentina
Fil: Guinjoan, Salvador M. Fundación FLENI. Servicio de Psiquiatría; Argentina
Fil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de psiquiatría y salud mental; Argentina
Fil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Psicología. Neurofisiología I; Argentina
Abstract: The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the purpose of detecting early structural and functional traits associated with the disorder, we sought to characterize cortical thickness and subcortical grey matter volume, cerebral metabolism, and amyloid deposition in persons at risk for LOAD in comparison with a similar group without family history of AD. We obtained 3T T1 images for gray matter volume, FDG-PET to evaluate regional cerebral metabolism, and PET-PiB to detect fibrillar amyloid deposition in 30 middle-aged, asymptomatic, cognitively normal individuals with one parent diagnosed with LOAD (O-LOAD), and 25 comparable controls (CS) without family history of neurodegenerative disorders (CS). We observed isocortical thinning in AD-relevant areas including posterior cingulate, precuneus, and areas of the prefrontal and temporoparietal cortex in O-LOAD. Unexpectedly, this group displayed increased cerebral metabolism, in some cases overlapping with the areas of cortical thinning, and no differences in bilateral hippocampal volume and hippocampal metabolism. Given the importance of age in this sample of individuals potentially developing early AD-related changes, we controlled results for age and observed that most differences in cortical thickness and metabolism became nonsignificant; however, greater deposition of β-amyloid was observed in the right hemisphere including temporoparietal cortex, postcentral gyrus, fusiform inferior and middle temporal and lingual gyri. If replicated, the present observations of morphological, metabolic, and amyloid changes in cognitively normal persons with family history of LOAD may bear important implications for the definition of very early phenotypes of this disorder.