Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit

Autores
Palumbo, María Laura; Di Rosso, María Emilia; Simón, Elías Hugo; González Murano, María Rosa; Genaro, Ana María
Año de publicación
2018
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Fil: Palumbo, María Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina
Fil: Di Rosso, María Emilia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Di Rosso, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Simón, Elías Hugo. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina
Fil: González Murano. María Rosa. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: González Murano. María Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Genaro, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina
Fil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Genaro, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.
Fuente
Cytokine. 2018;107:26-34
Materia
PROTEINAS
HIPOCAMPO
ESTRES
CITOQUINAS
GANGLIOS LINFATICOS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/8592
Acceder
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oai_identifier_str oai:ucacris:123456789/8592
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficitPalumbo, María LauraDi Rosso, María EmiliaSimón, Elías HugoGonzález Murano, María RosaGenaro, Ana MaríaPROTEINASHIPOCAMPOESTRESCITOQUINASGANGLIOS LINFATICOSFil: Palumbo, María Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; ArgentinaFil: Di Rosso, María Emilia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Di Rosso, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Simón, Elías Hugo. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; ArgentinaFil: González Murano. María Rosa. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: González Murano. María Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Genaro, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; ArgentinaFil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Genaro, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.Elsevier2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/85921043-466610.1016/j.cyto.2017.11.01029175260Palumbo ML, Di Rosso ME, Simon EH, Gonzalez Murano MR, Genaro AM. Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit [en línea]. Cytokine. 2018;107:26-34. doi:10.1016/j.cyto.2017.11.010 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8592Cytokine. 2018;107:26-34reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaspainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:52Zoai:ucacris:123456789/8592instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:52.493Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
spellingShingle Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
Palumbo, María Laura
PROTEINAS
HIPOCAMPO
ESTRES
CITOQUINAS
GANGLIOS LINFATICOS
title_short Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_full Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_fullStr Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_full_unstemmed Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_sort Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
dc.creator.none.fl_str_mv Palumbo, María Laura
Di Rosso, María Emilia
Simón, Elías Hugo
González Murano, María Rosa
Genaro, Ana María
author Palumbo, María Laura
author_facet Palumbo, María Laura
Di Rosso, María Emilia
Simón, Elías Hugo
González Murano, María Rosa
Genaro, Ana María
author_role author
author2 Di Rosso, María Emilia
Simón, Elías Hugo
González Murano, María Rosa
Genaro, Ana María
author2_role author
author
author
author
dc.subject.none.fl_str_mv PROTEINAS
HIPOCAMPO
ESTRES
CITOQUINAS
GANGLIOS LINFATICOS
topic PROTEINAS
HIPOCAMPO
ESTRES
CITOQUINAS
GANGLIOS LINFATICOS
dc.description.none.fl_txt_mv Fil: Palumbo, María Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina
Fil: Di Rosso, María Emilia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Di Rosso, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Simón, Elías Hugo. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina
Fil: González Murano. María Rosa. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: González Murano. María Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Genaro, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina
Fil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Genaro, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.
description Fil: Palumbo, María Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8592
1043-4666
10.1016/j.cyto.2017.11.010
29175260
Palumbo ML, Di Rosso ME, Simon EH, Gonzalez Murano MR, Genaro AM. Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit [en línea]. Cytokine. 2018;107:26-34. doi:10.1016/j.cyto.2017.11.010 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8592
url https://repositorio.uca.edu.ar/handle/123456789/8592
identifier_str_mv 1043-4666
10.1016/j.cyto.2017.11.010
29175260
Palumbo ML, Di Rosso ME, Simon EH, Gonzalez Murano MR, Genaro AM. Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit [en línea]. Cytokine. 2018;107:26-34. doi:10.1016/j.cyto.2017.11.010 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8592
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Cytokine. 2018;107:26-34
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.070432

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