Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
- Autores
- Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.
Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Simon, Elias Hugo. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Gonzalez Murano, Maria Rosa. Pontificia Universidad Católica Argentina ; Argentina
Fil: Genaro, Ana Maria. Pontificia Universidad Católica Argentina ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina - Materia
-
Chronic Stress
Cytokines
Hippocampus
Lymph Nodes
Glatiramer Acetate - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/48589
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Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficitPalumbo, María LauraDi Rosso, María EmiliaSimon, Elias HugoGonzalez Murano, Maria RosaGenaro, Ana MariaChronic StressCytokinesHippocampusLymph NodesGlatiramer Acetatehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Simon, Elias Hugo. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Gonzalez Murano, Maria Rosa. Pontificia Universidad Católica Argentina ; ArgentinaFil: Genaro, Ana Maria. Pontificia Universidad Católica Argentina ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2018-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48589Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria; Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 107; 7-2018; 26-341043-4666CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cyto.2017.11.010info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043466617303526info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:55Zoai:ri.conicet.gov.ar:11336/48589instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:55.653CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit |
title |
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit |
spellingShingle |
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit Palumbo, María Laura Chronic Stress Cytokines Hippocampus Lymph Nodes Glatiramer Acetate |
title_short |
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit |
title_full |
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit |
title_fullStr |
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit |
title_full_unstemmed |
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit |
title_sort |
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit |
dc.creator.none.fl_str_mv |
Palumbo, María Laura Di Rosso, María Emilia Simon, Elias Hugo Gonzalez Murano, Maria Rosa Genaro, Ana Maria |
author |
Palumbo, María Laura |
author_facet |
Palumbo, María Laura Di Rosso, María Emilia Simon, Elias Hugo Gonzalez Murano, Maria Rosa Genaro, Ana Maria |
author_role |
author |
author2 |
Di Rosso, María Emilia Simon, Elias Hugo Gonzalez Murano, Maria Rosa Genaro, Ana Maria |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Chronic Stress Cytokines Hippocampus Lymph Nodes Glatiramer Acetate |
topic |
Chronic Stress Cytokines Hippocampus Lymph Nodes Glatiramer Acetate |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response. Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina Fil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina Fil: Simon, Elias Hugo. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Gonzalez Murano, Maria Rosa. Pontificia Universidad Católica Argentina ; Argentina Fil: Genaro, Ana Maria. Pontificia Universidad Católica Argentina ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina |
description |
It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/48589 Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria; Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 107; 7-2018; 26-34 1043-4666 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/48589 |
identifier_str_mv |
Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria; Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 107; 7-2018; 26-34 1043-4666 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cyto.2017.11.010 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043466617303526 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press Ltd - Elsevier Science Ltd |
publisher.none.fl_str_mv |
Academic Press Ltd - Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613541982633984 |
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13.070432 |