Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit

Autores
Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.
Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Simon, Elias Hugo. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Gonzalez Murano, Maria Rosa. Pontificia Universidad Católica Argentina ; Argentina
Fil: Genaro, Ana Maria. Pontificia Universidad Católica Argentina ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Materia
Chronic Stress
Cytokines
Hippocampus
Lymph Nodes
Glatiramer Acetate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48589
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficitPalumbo, María LauraDi Rosso, María EmiliaSimon, Elias HugoGonzalez Murano, Maria RosaGenaro, Ana MariaChronic StressCytokinesHippocampusLymph NodesGlatiramer Acetatehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Simon, Elias Hugo. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Gonzalez Murano, Maria Rosa. Pontificia Universidad Católica Argentina ; ArgentinaFil: Genaro, Ana Maria. Pontificia Universidad Católica Argentina ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2018-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48589Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria; Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 107; 7-2018; 26-341043-4666CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cyto.2017.11.010info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043466617303526info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:19:15Zoai:ri.conicet.gov.ar:11336/48589instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:19:16.074CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
spellingShingle Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
Palumbo, María Laura
Chronic Stress
Cytokines
Hippocampus
Lymph Nodes
Glatiramer Acetate
title_short Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_full Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_fullStr Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_full_unstemmed Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_sort Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
dc.creator.none.fl_str_mv Palumbo, María Laura
Di Rosso, María Emilia
Simon, Elias Hugo
Gonzalez Murano, Maria Rosa
Genaro, Ana Maria
author Palumbo, María Laura
author_facet Palumbo, María Laura
Di Rosso, María Emilia
Simon, Elias Hugo
Gonzalez Murano, Maria Rosa
Genaro, Ana Maria
author_role author
author2 Di Rosso, María Emilia
Simon, Elias Hugo
Gonzalez Murano, Maria Rosa
Genaro, Ana Maria
author2_role author
author
author
author
dc.subject.none.fl_str_mv Chronic Stress
Cytokines
Hippocampus
Lymph Nodes
Glatiramer Acetate
topic Chronic Stress
Cytokines
Hippocampus
Lymph Nodes
Glatiramer Acetate
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.
Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Simon, Elias Hugo. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Gonzalez Murano, Maria Rosa. Pontificia Universidad Católica Argentina ; Argentina
Fil: Genaro, Ana Maria. Pontificia Universidad Católica Argentina ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
description It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.
publishDate 2018
dc.date.none.fl_str_mv 2018-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48589
Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria; Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 107; 7-2018; 26-34
1043-4666
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48589
identifier_str_mv Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria; Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 107; 7-2018; 26-34
1043-4666
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cyto.2017.11.010
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043466617303526
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781667562225664
score 13.229304

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