GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
- Autores
- Li, Zhi-Wei; Sun, Beicheng; Gong, Ting; Guo, Sheng; Zhang, Jianhua; Wang, Junlong; Sugawara, Atsushi; Jiang, Meisheng; Yan, Junjun; Gurary, Alexandra; Zheng, Xin; Gao, Bifeng; Xiao, Shu-Yuan; Chen, Wenlian; Ma, Chi; Farrar, Christine; Zhu, Chenjun; Chan, Owen T. M.; Xin, Can; Winnicki, Andrew; Winnicki, John; Tang, Mingxin; Park, Ryan; Winnicki, Mary; Diener, Katrina; Wang, Zhanwei; Liu, Qicai; Chu, Catherine H.; Arter, Zhaohui L.; Yue, Peibin; Alpert, Lindsay; Hui, George S.; Fei, Peiwen; Turkson, James; Yang, Wentian; Wu, Guangyu; Tao, Ailin; Ramos, Joe W.; Moisyadi, Stefan; Holcombe, Randall F.; Jia, Wei; Birnbaumer, Lutz; Zhou, Xiqiao; Chu, Wen-Ming
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión aceptada
- Descripción
- Fil: Li, Zhi-Wei. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Sun, Beicheng. Nanjing University Medical School. The Affiliated Drum Tower Hospital. Department of Hepatobiliary Surgery; China
Fil: Gong, Ting. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Guo, Sheng. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Guo, Sheng. Shanghai Jiao Tong University. Shanghai Children’s Hospital. Department of Endocrine, Genetics and Metabolism; China
Fil: Zhang, Jianhua. University of Hawaii. Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Zhang, Jianhua. Shanghai Jiao Tong University. School of Medicine. Xinhua Hospital. Department of Pediatrics; China
Fil: Wang, Junlong. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Sugawara, Atsushi. University of Hawaii. John A. Burns School of Medicine. Institute for Biogenesis Research; Estados Unidos
Fil: Jiang, Meisheng. University of California. Department of Molecular and Medical Pharmacology; Estados Unidos
Fil: Yan, Junjun. Nanjing Medical University. The First Affiliated Hospital. Department of Gastroenterology; China
Fil: Gurary, Alexandra. University of Hawaii. John A. Burns School of Medicine. Department of Tropical Medicine, Medical Microbiology, and Pharmacology; Estados Unidos
Fil: Zheng, Xin. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Gao, Bifeng. University of Colorado Anschutz Medical Campus. Department of Medicine; Estados Unidos
Fil: Xiao, Shu-Yuan. Wuhan University. Zhongnan Hospital. Department of Pathology; China
Fil: Xiao, Shu-Yuan. University of Chicago. Department of Pathology; Estados Unidos
Fil: Chen, Wenlian. University of Hawaii. Cancer Center. Epidemiology Program; Estados Unidos
Fil: Ma, Chi. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Farrar, Christine. University of Hawaii Cancer Center. The Microscopy, Imaging, and Flow Cytometry Shared Resource; Estados Unidos
Fil: Zhu, Chenjun. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Chan, Owen T. M. University of Hawaii Cancer Center. Pathology Core; Estados Unidos
Fil: Xin, Can. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Winnicki, Andrew. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Winnicki, John. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Tang, Mingxin. University of Hawaii. John A. Burns School of Medicine. Center for Cardiovascular Research; Estados Unidos
Fil: Park, Ryan. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Winnicki, Mary. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Diener, Katrina. University of Colorado Anschutz Medical Campus. Department of Medicine; Estados Unidos
Fil: Wang, Zhanwei. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Liu, Qicai. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Liu, Qicai. Southern Medical University. Zhujiang Hospital. Department of Cardiology and Heart Center; China
Fil: Chu, Catherine H. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Arter, Zhaohui L. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Yue, Peibin. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Alpert, Lindsay. University of Chicago. Department of Pathology; Estados Unidos
Fil: Hui, George S. University of Hawaii. John A. Burns School of Medicine. Department of Tropical Medicine, Medical Microbiology, and Pharmacology; Estados Unidos
Fil: Fei, Peiwen. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Yang, Wentian. Brown University. Alpert Medical School. Rhode Island Hospital
Fil: Wu, Guangyu. Augusta University. Department of Pharmacology and Toxicology; Estados Unidos
Fil: Tao, Ailin. Guangzhou Medical University. Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology. The State Key Laboratory of Respiratory Disease. The Second Affiliated Hospital; China
Fil: Ramos, Joe W. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Moisyadi, Stefan. University of Hawaii. John A. Burns School of Medicine. Institute for Biogenesis Research; Estados Unidos
Fil: Holcombe, Randall F. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Jia, Wei. University of Hawaii Cancer Center. Epidemiology Program; Estados Unidos
Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Zhou, Xiqiao. Nanjing Medical University. The First Affiliated Hospital. Department of Gastroenterology; China
Fil: Chu, Wen-Ming. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos
Fil: Chu, Wen-Ming. Guangzhou Medical University. Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology. The State Key Laboratory of Respiratory Disease. The Second Affiliated Hospital; China
Abstract: Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. GNAI1;3 suppresses DSS-plus-AOM–induced colon tumor development in mice, whereas expression of GNAI2 in CD11c+ cells and IL6 in CD4+/CD11b+ DCs appears to promote these effects. Strategies to induce GNAI1;3, or block GNAI2 and IL6, might be developed for the prevention or therapy of CAC in patients. - Fuente
- Gastroenterology. 2019, 156(8)
- Materia
-
CANCER
TUMORES
COLITIS
CARCINOGENESIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/9271
Ver los metadatos del registro completo
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GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2Li, Zhi-WeiSun, BeichengGong, TingGuo, ShengZhang, JianhuaWang, JunlongSugawara, AtsushiJiang, MeishengYan, JunjunGurary, AlexandraZheng, XinGao, BifengXiao, Shu-YuanChen, WenlianMa, ChiFarrar, ChristineZhu, ChenjunChan, Owen T. M.Xin, CanWinnicki, AndrewWinnicki, JohnTang, MingxinPark, RyanWinnicki, MaryDiener, KatrinaWang, ZhanweiLiu, QicaiChu, Catherine H.Arter, Zhaohui L.Yue, PeibinAlpert, LindsayHui, George S.Fei, PeiwenTurkson, JamesYang, WentianWu, GuangyuTao, AilinRamos, Joe W.Moisyadi, StefanHolcombe, Randall F.Jia, WeiBirnbaumer, LutzZhou, XiqiaoChu, Wen-MingCANCERTUMORESCOLITISCARCINOGENESISFil: Li, Zhi-Wei. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Sun, Beicheng. Nanjing University Medical School. The Affiliated Drum Tower Hospital. Department of Hepatobiliary Surgery; ChinaFil: Gong, Ting. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Guo, Sheng. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Guo, Sheng. Shanghai Jiao Tong University. Shanghai Children’s Hospital. Department of Endocrine, Genetics and Metabolism; ChinaFil: Zhang, Jianhua. University of Hawaii. Cancer Center. Cancer Biology Program; Estados UnidosFil: Zhang, Jianhua. Shanghai Jiao Tong University. School of Medicine. Xinhua Hospital. Department of Pediatrics; ChinaFil: Wang, Junlong. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Sugawara, Atsushi. University of Hawaii. John A. Burns School of Medicine. Institute for Biogenesis Research; Estados UnidosFil: Jiang, Meisheng. University of California. Department of Molecular and Medical Pharmacology; Estados UnidosFil: Yan, Junjun. Nanjing Medical University. The First Affiliated Hospital. Department of Gastroenterology; ChinaFil: Gurary, Alexandra. University of Hawaii. John A. Burns School of Medicine. Department of Tropical Medicine, Medical Microbiology, and Pharmacology; Estados UnidosFil: Zheng, Xin. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Gao, Bifeng. University of Colorado Anschutz Medical Campus. Department of Medicine; Estados UnidosFil: Xiao, Shu-Yuan. Wuhan University. Zhongnan Hospital. Department of Pathology; ChinaFil: Xiao, Shu-Yuan. University of Chicago. Department of Pathology; Estados UnidosFil: Chen, Wenlian. University of Hawaii. Cancer Center. Epidemiology Program; Estados UnidosFil: Ma, Chi. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Farrar, Christine. University of Hawaii Cancer Center. The Microscopy, Imaging, and Flow Cytometry Shared Resource; Estados UnidosFil: Zhu, Chenjun. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Chan, Owen T. M. University of Hawaii Cancer Center. Pathology Core; Estados UnidosFil: Xin, Can. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Winnicki, Andrew. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Winnicki, John. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Tang, Mingxin. University of Hawaii. John A. Burns School of Medicine. Center for Cardiovascular Research; Estados UnidosFil: Park, Ryan. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Winnicki, Mary. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Diener, Katrina. University of Colorado Anschutz Medical Campus. Department of Medicine; Estados UnidosFil: Wang, Zhanwei. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Liu, Qicai. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Liu, Qicai. Southern Medical University. Zhujiang Hospital. Department of Cardiology and Heart Center; ChinaFil: Chu, Catherine H. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Arter, Zhaohui L. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Yue, Peibin. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Alpert, Lindsay. University of Chicago. Department of Pathology; Estados UnidosFil: Hui, George S. University of Hawaii. John A. Burns School of Medicine. Department of Tropical Medicine, Medical Microbiology, and Pharmacology; Estados UnidosFil: Fei, Peiwen. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Yang, Wentian. Brown University. Alpert Medical School. Rhode Island HospitalFil: Wu, Guangyu. Augusta University. Department of Pharmacology and Toxicology; Estados UnidosFil: Tao, Ailin. Guangzhou Medical University. Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology. The State Key Laboratory of Respiratory Disease. The Second Affiliated Hospital; ChinaFil: Ramos, Joe W. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Moisyadi, Stefan. University of Hawaii. John A. Burns School of Medicine. Institute for Biogenesis Research; Estados UnidosFil: Holcombe, Randall F. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Jia, Wei. University of Hawaii Cancer Center. Epidemiology Program; Estados UnidosFil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados UnidosFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Zhou, Xiqiao. Nanjing Medical University. The First Affiliated Hospital. Department of Gastroenterology; ChinaFil: Chu, Wen-Ming. University of Hawaii Cancer Center. Cancer Biology Program; Estados UnidosFil: Chu, Wen-Ming. Guangzhou Medical University. Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology. The State Key Laboratory of Respiratory Disease. The Second Affiliated Hospital; ChinaAbstract: Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. GNAI1;3 suppresses DSS-plus-AOM–induced colon tumor development in mice, whereas expression of GNAI2 in CD11c+ cells and IL6 in CD4+/CD11b+ DCs appears to promote these effects. Strategies to induce GNAI1;3, or block GNAI2 and IL6, might be developed for the prevention or therapy of CAC in patients.Elsevier2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/92710016-508510.1053/j.gastro.2019.02.04030836096Li, Z. et al. GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 [en línea]. Gastroenterology. 2019, 156(8). doi:10.1053/j.gastro.2019.02.040 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9271Gastroenterology. 2019, 156(8)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:57:04Zoai:ucacris:123456789/9271instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:57:04.832Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
| dc.title.none.fl_str_mv |
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 |
| title |
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 |
| spellingShingle |
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 Li, Zhi-Wei CANCER TUMORES COLITIS CARCINOGENESIS |
| title_short |
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 |
| title_full |
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 |
| title_fullStr |
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 |
| title_full_unstemmed |
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 |
| title_sort |
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 |
| dc.creator.none.fl_str_mv |
Li, Zhi-Wei Sun, Beicheng Gong, Ting Guo, Sheng Zhang, Jianhua Wang, Junlong Sugawara, Atsushi Jiang, Meisheng Yan, Junjun Gurary, Alexandra Zheng, Xin Gao, Bifeng Xiao, Shu-Yuan Chen, Wenlian Ma, Chi Farrar, Christine Zhu, Chenjun Chan, Owen T. M. Xin, Can Winnicki, Andrew Winnicki, John Tang, Mingxin Park, Ryan Winnicki, Mary Diener, Katrina Wang, Zhanwei Liu, Qicai Chu, Catherine H. Arter, Zhaohui L. Yue, Peibin Alpert, Lindsay Hui, George S. Fei, Peiwen Turkson, James Yang, Wentian Wu, Guangyu Tao, Ailin Ramos, Joe W. Moisyadi, Stefan Holcombe, Randall F. Jia, Wei Birnbaumer, Lutz Zhou, Xiqiao Chu, Wen-Ming |
| author |
Li, Zhi-Wei |
| author_facet |
Li, Zhi-Wei Sun, Beicheng Gong, Ting Guo, Sheng Zhang, Jianhua Wang, Junlong Sugawara, Atsushi Jiang, Meisheng Yan, Junjun Gurary, Alexandra Zheng, Xin Gao, Bifeng Xiao, Shu-Yuan Chen, Wenlian Ma, Chi Farrar, Christine Zhu, Chenjun Chan, Owen T. M. Xin, Can Winnicki, Andrew Winnicki, John Tang, Mingxin Park, Ryan Winnicki, Mary Diener, Katrina Wang, Zhanwei Liu, Qicai Chu, Catherine H. Arter, Zhaohui L. Yue, Peibin Alpert, Lindsay Hui, George S. Fei, Peiwen Turkson, James Yang, Wentian Wu, Guangyu Tao, Ailin Ramos, Joe W. Moisyadi, Stefan Holcombe, Randall F. Jia, Wei Birnbaumer, Lutz Zhou, Xiqiao Chu, Wen-Ming |
| author_role |
author |
| author2 |
Sun, Beicheng Gong, Ting Guo, Sheng Zhang, Jianhua Wang, Junlong Sugawara, Atsushi Jiang, Meisheng Yan, Junjun Gurary, Alexandra Zheng, Xin Gao, Bifeng Xiao, Shu-Yuan Chen, Wenlian Ma, Chi Farrar, Christine Zhu, Chenjun Chan, Owen T. M. Xin, Can Winnicki, Andrew Winnicki, John Tang, Mingxin Park, Ryan Winnicki, Mary Diener, Katrina Wang, Zhanwei Liu, Qicai Chu, Catherine H. Arter, Zhaohui L. Yue, Peibin Alpert, Lindsay Hui, George S. Fei, Peiwen Turkson, James Yang, Wentian Wu, Guangyu Tao, Ailin Ramos, Joe W. Moisyadi, Stefan Holcombe, Randall F. Jia, Wei Birnbaumer, Lutz Zhou, Xiqiao Chu, Wen-Ming |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
CANCER TUMORES COLITIS CARCINOGENESIS |
| topic |
CANCER TUMORES COLITIS CARCINOGENESIS |
| dc.description.none.fl_txt_mv |
Fil: Li, Zhi-Wei. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Sun, Beicheng. Nanjing University Medical School. The Affiliated Drum Tower Hospital. Department of Hepatobiliary Surgery; China Fil: Gong, Ting. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Guo, Sheng. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Guo, Sheng. Shanghai Jiao Tong University. Shanghai Children’s Hospital. Department of Endocrine, Genetics and Metabolism; China Fil: Zhang, Jianhua. University of Hawaii. Cancer Center. Cancer Biology Program; Estados Unidos Fil: Zhang, Jianhua. Shanghai Jiao Tong University. School of Medicine. Xinhua Hospital. Department of Pediatrics; China Fil: Wang, Junlong. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Sugawara, Atsushi. University of Hawaii. John A. Burns School of Medicine. Institute for Biogenesis Research; Estados Unidos Fil: Jiang, Meisheng. University of California. Department of Molecular and Medical Pharmacology; Estados Unidos Fil: Yan, Junjun. Nanjing Medical University. The First Affiliated Hospital. Department of Gastroenterology; China Fil: Gurary, Alexandra. University of Hawaii. John A. Burns School of Medicine. Department of Tropical Medicine, Medical Microbiology, and Pharmacology; Estados Unidos Fil: Zheng, Xin. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Gao, Bifeng. University of Colorado Anschutz Medical Campus. Department of Medicine; Estados Unidos Fil: Xiao, Shu-Yuan. Wuhan University. Zhongnan Hospital. Department of Pathology; China Fil: Xiao, Shu-Yuan. University of Chicago. Department of Pathology; Estados Unidos Fil: Chen, Wenlian. University of Hawaii. Cancer Center. Epidemiology Program; Estados Unidos Fil: Ma, Chi. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Farrar, Christine. University of Hawaii Cancer Center. The Microscopy, Imaging, and Flow Cytometry Shared Resource; Estados Unidos Fil: Zhu, Chenjun. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Chan, Owen T. M. University of Hawaii Cancer Center. Pathology Core; Estados Unidos Fil: Xin, Can. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Winnicki, Andrew. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Winnicki, John. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Tang, Mingxin. University of Hawaii. John A. Burns School of Medicine. Center for Cardiovascular Research; Estados Unidos Fil: Park, Ryan. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Winnicki, Mary. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Diener, Katrina. University of Colorado Anschutz Medical Campus. Department of Medicine; Estados Unidos Fil: Wang, Zhanwei. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Liu, Qicai. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Liu, Qicai. Southern Medical University. Zhujiang Hospital. Department of Cardiology and Heart Center; China Fil: Chu, Catherine H. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Arter, Zhaohui L. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Yue, Peibin. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Alpert, Lindsay. University of Chicago. Department of Pathology; Estados Unidos Fil: Hui, George S. University of Hawaii. John A. Burns School of Medicine. Department of Tropical Medicine, Medical Microbiology, and Pharmacology; Estados Unidos Fil: Fei, Peiwen. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Yang, Wentian. Brown University. Alpert Medical School. Rhode Island Hospital Fil: Wu, Guangyu. Augusta University. Department of Pharmacology and Toxicology; Estados Unidos Fil: Tao, Ailin. Guangzhou Medical University. Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology. The State Key Laboratory of Respiratory Disease. The Second Affiliated Hospital; China Fil: Ramos, Joe W. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Moisyadi, Stefan. University of Hawaii. John A. Burns School of Medicine. Institute for Biogenesis Research; Estados Unidos Fil: Holcombe, Randall F. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Jia, Wei. University of Hawaii Cancer Center. Epidemiology Program; Estados Unidos Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina Fil: Zhou, Xiqiao. Nanjing Medical University. The First Affiliated Hospital. Department of Gastroenterology; China Fil: Chu, Wen-Ming. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos Fil: Chu, Wen-Ming. Guangzhou Medical University. Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology. The State Key Laboratory of Respiratory Disease. The Second Affiliated Hospital; China Abstract: Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. GNAI1;3 suppresses DSS-plus-AOM–induced colon tumor development in mice, whereas expression of GNAI2 in CD11c+ cells and IL6 in CD4+/CD11b+ DCs appears to promote these effects. Strategies to induce GNAI1;3, or block GNAI2 and IL6, might be developed for the prevention or therapy of CAC in patients. |
| description |
Fil: Li, Zhi-Wei. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
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info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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acceptedVersion |
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https://repositorio.uca.edu.ar/handle/123456789/9271 0016-5085 10.1053/j.gastro.2019.02.040 30836096 Li, Z. et al. GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 [en línea]. Gastroenterology. 2019, 156(8). doi:10.1053/j.gastro.2019.02.040 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9271 |
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https://repositorio.uca.edu.ar/handle/123456789/9271 |
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0016-5085 10.1053/j.gastro.2019.02.040 30836096 Li, Z. et al. GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 [en línea]. Gastroenterology. 2019, 156(8). doi:10.1053/j.gastro.2019.02.040 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9271 |
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eng |
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eng |
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Elsevier |
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Elsevier |
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Gastroenterology. 2019, 156(8) reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
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