Galectin-1 suppresses experimental colitis in mice

Autores
Santucci, Luca; Fiorucci, Stefano; Rubinstein, Natalia; Mencarelli, Andrea; Pallazzeti, Barbara; Federici, Barbara; Rabinovich, Gabriel Adrián; Morelli, Antonio
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting inappropriately activated T cells could be efficacious in the treatment of these pathologic conditions. Galectin-1 is an endogenous lectin expressed in lymphoid organs that plays a role in the maintenance of central and peripheral tolerance. The aim of the present study was to evaluate the therapeutic effects of galectin-1 on T-helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice.
Fil: Santucci, Luca. Università di Perugia; Italia
Fil: Fiorucci, Stefano. Università di Perugia; Italia
Fil: Rubinstein, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Mencarelli, Andrea. Università di Perugia; Italia
Fil: Pallazzeti, Barbara. Università di Perugia; Italia
Fil: Federici, Barbara. Università di Perugia; Italia
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Morelli, Antonio. Università di Perugia; Italia
Materia
Autoimmune Colitis
Galectin-1
Tumor Necrosis Factor Alpha
Human Recombinant Galectin
Irritable Bowel Disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/36410
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/36410
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Galectin-1 suppresses experimental colitis in miceSantucci, LucaFiorucci, StefanoRubinstein, NataliaMencarelli, AndreaPallazzeti, BarbaraFederici, BarbaraRabinovich, Gabriel AdriánMorelli, AntonioAutoimmune ColitisGalectin-1Tumor Necrosis Factor AlphaHuman Recombinant GalectinIrritable Bowel Diseasehttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting inappropriately activated T cells could be efficacious in the treatment of these pathologic conditions. Galectin-1 is an endogenous lectin expressed in lymphoid organs that plays a role in the maintenance of central and peripheral tolerance. The aim of the present study was to evaluate the therapeutic effects of galectin-1 on T-helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice.Fil: Santucci, Luca. Università di Perugia; ItaliaFil: Fiorucci, Stefano. Università di Perugia; ItaliaFil: Rubinstein, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Mencarelli, Andrea. Università di Perugia; ItaliaFil: Pallazzeti, Barbara. Università di Perugia; ItaliaFil: Federici, Barbara. Università di Perugia; ItaliaFil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Morelli, Antonio. Università di Perugia; ItaliaAmerican Gastroenterological Association2003-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/36410Santucci, Luca; Fiorucci, Stefano; Rubinstein, Natalia; Mencarelli, Andrea; Pallazzeti, Barbara; et al.; Galectin-1 suppresses experimental colitis in mice; American Gastroenterological Association; Gastroenterology; 124; 5; 5-2003; 1381-13940016-5085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0016508503002671info:eu-repo/semantics/altIdentifier/doi/10.1016/S0016-5085(03)00267-1info:eu-repo/semantics/altIdentifier/pmid/12730878info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:36Zoai:ri.conicet.gov.ar:11336/36410instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:36.609CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Galectin-1 suppresses experimental colitis in mice
title Galectin-1 suppresses experimental colitis in mice
spellingShingle Galectin-1 suppresses experimental colitis in mice
Santucci, Luca
Autoimmune Colitis
Galectin-1
Tumor Necrosis Factor Alpha
Human Recombinant Galectin
Irritable Bowel Disease
title_short Galectin-1 suppresses experimental colitis in mice
title_full Galectin-1 suppresses experimental colitis in mice
title_fullStr Galectin-1 suppresses experimental colitis in mice
title_full_unstemmed Galectin-1 suppresses experimental colitis in mice
title_sort Galectin-1 suppresses experimental colitis in mice
dc.creator.none.fl_str_mv Santucci, Luca
Fiorucci, Stefano
Rubinstein, Natalia
Mencarelli, Andrea
Pallazzeti, Barbara
Federici, Barbara
Rabinovich, Gabriel Adrián
Morelli, Antonio
author Santucci, Luca
author_facet Santucci, Luca
Fiorucci, Stefano
Rubinstein, Natalia
Mencarelli, Andrea
Pallazzeti, Barbara
Federici, Barbara
Rabinovich, Gabriel Adrián
Morelli, Antonio
author_role author
author2 Fiorucci, Stefano
Rubinstein, Natalia
Mencarelli, Andrea
Pallazzeti, Barbara
Federici, Barbara
Rabinovich, Gabriel Adrián
Morelli, Antonio
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Autoimmune Colitis
Galectin-1
Tumor Necrosis Factor Alpha
Human Recombinant Galectin
Irritable Bowel Disease
topic Autoimmune Colitis
Galectin-1
Tumor Necrosis Factor Alpha
Human Recombinant Galectin
Irritable Bowel Disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting inappropriately activated T cells could be efficacious in the treatment of these pathologic conditions. Galectin-1 is an endogenous lectin expressed in lymphoid organs that plays a role in the maintenance of central and peripheral tolerance. The aim of the present study was to evaluate the therapeutic effects of galectin-1 on T-helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice.
Fil: Santucci, Luca. Università di Perugia; Italia
Fil: Fiorucci, Stefano. Università di Perugia; Italia
Fil: Rubinstein, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Mencarelli, Andrea. Università di Perugia; Italia
Fil: Pallazzeti, Barbara. Università di Perugia; Italia
Fil: Federici, Barbara. Università di Perugia; Italia
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Morelli, Antonio. Università di Perugia; Italia
description Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting inappropriately activated T cells could be efficacious in the treatment of these pathologic conditions. Galectin-1 is an endogenous lectin expressed in lymphoid organs that plays a role in the maintenance of central and peripheral tolerance. The aim of the present study was to evaluate the therapeutic effects of galectin-1 on T-helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice.
publishDate 2003
dc.date.none.fl_str_mv 2003-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/36410
Santucci, Luca; Fiorucci, Stefano; Rubinstein, Natalia; Mencarelli, Andrea; Pallazzeti, Barbara; et al.; Galectin-1 suppresses experimental colitis in mice; American Gastroenterological Association; Gastroenterology; 124; 5; 5-2003; 1381-1394
0016-5085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/36410
identifier_str_mv Santucci, Luca; Fiorucci, Stefano; Rubinstein, Natalia; Mencarelli, Andrea; Pallazzeti, Barbara; et al.; Galectin-1 suppresses experimental colitis in mice; American Gastroenterological Association; Gastroenterology; 124; 5; 5-2003; 1381-1394
0016-5085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0016508503002671
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0016-5085(03)00267-1
info:eu-repo/semantics/altIdentifier/pmid/12730878
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Gastroenterological Association
publisher.none.fl_str_mv American Gastroenterological Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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