Understanding the role of sleep and its disturbances in autism spectrum disorder

Autores
Karthikeyan, Ramanujam; Cardinali, Daniel Pedro; Shakunthala, Venkat; Spence, David Warren; Brown, Gregory M.; Pandi Perumal, Seithikurippu R.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Fil: Karthikeyan, Ramanujam. School of Biological Sciences. Department of Animal Behavior & Physiology; India
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Medicas; Argentina
Fil: Shakunthala, Venkat. University of Mysuru. Department of Zoology; India
Fil: Spence, David Warren. Independent Research Consultant; Canada
Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health. Molecular Brain Science; Canada
Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc.; Canada
Abstract: Sleep difficulties are one of the significant complications associated with autism spectrum disorder (ASD). Despite their possible role as contributors to the overall symptoms of ASD, the symptoms of disturbed sleep experienced by many affected patients have only recently started to receive attention from clinicians, caretakers, and family members. Many types of sleep disorders have been reported in ASD individuals, but these have not been categorized under a common terminology. Nevertheless, several studies have established that a positive relationship exists between the occurrence of sleep difficulties and heightenedsymptomatology in ASD children. When ASD children show evidence of sleep problems there is also an increased frequency of behavioral problems such as social impairment, decreased cognitive functioning, aggressiveness, and anxiety. Several hypotheses have been put forward regarding the linkage between disturbed sleep and ASD. These have included suggestions that sleep difficulties and other ASD symptoms are induced by disruption of the circadian clock, the presence of comorbid physical or psychological conditions, elevated anxiety levels, or emotional distress. This article reviews the use of sleep therapies in ASD, among which melatonin has shown promise because of its lack ofsignificant side effects. A better understanding of sleep problems in the etiology of ASD, their impact on the symptoms and behavior of ASD individuals, and their potential use as a secondary aid for treating ASD would represent a significant contribution todevelop strategies to manage the disorder.
Fuente
International Journal of Neuroscience Vol. 130, No.10.2020
Materia
TRASTORNO DEL ESPECTRO AUTISTA
TRASTORNOS DEL SUEÑO
MELATONINA
TRATAMIENTO TERAPEUTICO
AUTISMO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/13666

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network_name_str Repositorio Institucional (UCA)
spelling Understanding the role of sleep and its disturbances in autism spectrum disorderKarthikeyan, RamanujamCardinali, Daniel PedroShakunthala, VenkatSpence, David WarrenBrown, Gregory M.Pandi Perumal, Seithikurippu R.TRASTORNO DEL ESPECTRO AUTISTATRASTORNOS DEL SUEÑOMELATONINATRATAMIENTO TERAPEUTICOAUTISMOFil: Karthikeyan, Ramanujam. School of Biological Sciences. Department of Animal Behavior & Physiology; IndiaFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Medicas; ArgentinaFil: Shakunthala, Venkat. University of Mysuru. Department of Zoology; IndiaFil: Spence, David Warren. Independent Research Consultant; CanadaFil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health. Molecular Brain Science; CanadaFil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc.; CanadaAbstract: Sleep difficulties are one of the significant complications associated with autism spectrum disorder (ASD). Despite their possible role as contributors to the overall symptoms of ASD, the symptoms of disturbed sleep experienced by many affected patients have only recently started to receive attention from clinicians, caretakers, and family members. Many types of sleep disorders have been reported in ASD individuals, but these have not been categorized under a common terminology. Nevertheless, several studies have established that a positive relationship exists between the occurrence of sleep difficulties and heightenedsymptomatology in ASD children. When ASD children show evidence of sleep problems there is also an increased frequency of behavioral problems such as social impairment, decreased cognitive functioning, aggressiveness, and anxiety. Several hypotheses have been put forward regarding the linkage between disturbed sleep and ASD. These have included suggestions that sleep difficulties and other ASD symptoms are induced by disruption of the circadian clock, the presence of comorbid physical or psychological conditions, elevated anxiety levels, or emotional distress. This article reviews the use of sleep therapies in ASD, among which melatonin has shown promise because of its lack ofsignificant side effects. A better understanding of sleep problems in the etiology of ASD, their impact on the symptoms and behavior of ASD individuals, and their potential use as a secondary aid for treating ASD would represent a significant contribution todevelop strategies to manage the disorder.Taylor & Francis2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/136660020-74541543-5245 (online)10.1080/00207454.2019.1711377Karthikeyan, R., Cardinali, D. P., Shakunthala, V., Spence, D. W., Brown, G.M., Pandi Perumal, S. R. Understanding the role of sleep and its disturbances in autism spectrum disorder [en línea]. Postprint del artículo publicado en: International Journal of Neuroscience. 2020, 130 (10). doi: 10.1080/00207454.2019.1711377. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13666International Journal of Neuroscience Vol. 130, No.10.2020reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:30Zoai:ucacris:123456789/13666instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:30.364Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Understanding the role of sleep and its disturbances in autism spectrum disorder
title Understanding the role of sleep and its disturbances in autism spectrum disorder
spellingShingle Understanding the role of sleep and its disturbances in autism spectrum disorder
Karthikeyan, Ramanujam
TRASTORNO DEL ESPECTRO AUTISTA
TRASTORNOS DEL SUEÑO
MELATONINA
TRATAMIENTO TERAPEUTICO
AUTISMO
title_short Understanding the role of sleep and its disturbances in autism spectrum disorder
title_full Understanding the role of sleep and its disturbances in autism spectrum disorder
title_fullStr Understanding the role of sleep and its disturbances in autism spectrum disorder
title_full_unstemmed Understanding the role of sleep and its disturbances in autism spectrum disorder
title_sort Understanding the role of sleep and its disturbances in autism spectrum disorder
dc.creator.none.fl_str_mv Karthikeyan, Ramanujam
Cardinali, Daniel Pedro
Shakunthala, Venkat
Spence, David Warren
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author Karthikeyan, Ramanujam
author_facet Karthikeyan, Ramanujam
Cardinali, Daniel Pedro
Shakunthala, Venkat
Spence, David Warren
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_role author
author2 Cardinali, Daniel Pedro
Shakunthala, Venkat
Spence, David Warren
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv TRASTORNO DEL ESPECTRO AUTISTA
TRASTORNOS DEL SUEÑO
MELATONINA
TRATAMIENTO TERAPEUTICO
AUTISMO
topic TRASTORNO DEL ESPECTRO AUTISTA
TRASTORNOS DEL SUEÑO
MELATONINA
TRATAMIENTO TERAPEUTICO
AUTISMO
dc.description.none.fl_txt_mv Fil: Karthikeyan, Ramanujam. School of Biological Sciences. Department of Animal Behavior & Physiology; India
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Medicas; Argentina
Fil: Shakunthala, Venkat. University of Mysuru. Department of Zoology; India
Fil: Spence, David Warren. Independent Research Consultant; Canada
Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health. Molecular Brain Science; Canada
Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc.; Canada
Abstract: Sleep difficulties are one of the significant complications associated with autism spectrum disorder (ASD). Despite their possible role as contributors to the overall symptoms of ASD, the symptoms of disturbed sleep experienced by many affected patients have only recently started to receive attention from clinicians, caretakers, and family members. Many types of sleep disorders have been reported in ASD individuals, but these have not been categorized under a common terminology. Nevertheless, several studies have established that a positive relationship exists between the occurrence of sleep difficulties and heightenedsymptomatology in ASD children. When ASD children show evidence of sleep problems there is also an increased frequency of behavioral problems such as social impairment, decreased cognitive functioning, aggressiveness, and anxiety. Several hypotheses have been put forward regarding the linkage between disturbed sleep and ASD. These have included suggestions that sleep difficulties and other ASD symptoms are induced by disruption of the circadian clock, the presence of comorbid physical or psychological conditions, elevated anxiety levels, or emotional distress. This article reviews the use of sleep therapies in ASD, among which melatonin has shown promise because of its lack ofsignificant side effects. A better understanding of sleep problems in the etiology of ASD, their impact on the symptoms and behavior of ASD individuals, and their potential use as a secondary aid for treating ASD would represent a significant contribution todevelop strategies to manage the disorder.
description Fil: Karthikeyan, Ramanujam. School of Biological Sciences. Department of Animal Behavior & Physiology; India
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/13666
0020-7454
1543-5245 (online)
10.1080/00207454.2019.1711377
Karthikeyan, R., Cardinali, D. P., Shakunthala, V., Spence, D. W., Brown, G.M., Pandi Perumal, S. R. Understanding the role of sleep and its disturbances in autism spectrum disorder [en línea]. Postprint del artículo publicado en: International Journal of Neuroscience. 2020, 130 (10). doi: 10.1080/00207454.2019.1711377. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13666
url https://repositorio.uca.edu.ar/handle/123456789/13666
identifier_str_mv 0020-7454
1543-5245 (online)
10.1080/00207454.2019.1711377
Karthikeyan, R., Cardinali, D. P., Shakunthala, V., Spence, D. W., Brown, G.M., Pandi Perumal, S. R. Understanding the role of sleep and its disturbances in autism spectrum disorder [en línea]. Postprint del artículo publicado en: International Journal of Neuroscience. 2020, 130 (10). doi: 10.1080/00207454.2019.1711377. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13666
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv International Journal of Neuroscience Vol. 130, No.10.2020
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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