Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin

Autores
Brown, Gregory M.; Karthikeyan, Ramanujam; Pandi Perumal, Seithikurippu R.; Cardinali, Daniel Pedro
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; Canadá
Fil: Karthikeyan, Ramanujam. Investigador independiente; India
Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultaf de Ciencias Médicas; Argentina
Abstract: Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reported that many of those with ASD have substantial sleep disorders with low levels of melatonin and various genetic alterations related to melatonin production have been found. Several lines of evidence point to a substantial role of melatonin in the body’s innate defense system including acting as a scavenger, an antioxidant and modulating the immune system. We therefore hypothesize that melatonin deficiency may predispose those ASD patients who have low melatonin output to COVID-19 disease. Potential implications for treatment are discussed.
Fuente
Medical Hypotheses. 2021, 149
Materia
TRASTORNO DEL ESPECTRO AUTISTA
COVID-19
SARS-CoV-2
MELATONINA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/18344
Acceder
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oai_identifier_str oai:ucacris:123456789/18344
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatoninBrown, Gregory M.Karthikeyan, RamanujamPandi Perumal, Seithikurippu R.Cardinali, Daniel PedroTRASTORNO DEL ESPECTRO AUTISTACOVID-19SARS-CoV-2MELATONINAFil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; CanadáFil: Karthikeyan, Ramanujam. Investigador independiente; IndiaFil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; CanadáFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultaf de Ciencias Médicas; ArgentinaAbstract: Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reported that many of those with ASD have substantial sleep disorders with low levels of melatonin and various genetic alterations related to melatonin production have been found. Several lines of evidence point to a substantial role of melatonin in the body’s innate defense system including acting as a scavenger, an antioxidant and modulating the immune system. We therefore hypothesize that melatonin deficiency may predispose those ASD patients who have low melatonin output to COVID-19 disease. Potential implications for treatment are discussed.Elsevier2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/183440306-987710.1016/j.mehy.2021.110544Brown, G. M. et al. Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin [en línea]. Medical Hypotheses. 2021, 149 . doi: 10.1016/j.mehy.2021.110544. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18344Medical Hypotheses. 2021, 149reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:59:50Zoai:ucacris:123456789/18344instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:50.307Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
spellingShingle Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
Brown, Gregory M.
TRASTORNO DEL ESPECTRO AUTISTA
COVID-19
SARS-CoV-2
MELATONINA
title_short Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_full Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_fullStr Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_full_unstemmed Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_sort Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
dc.creator.none.fl_str_mv Brown, Gregory M.
Karthikeyan, Ramanujam
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
author Brown, Gregory M.
author_facet Brown, Gregory M.
Karthikeyan, Ramanujam
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
author_role author
author2 Karthikeyan, Ramanujam
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
author2_role author
author
author
dc.subject.none.fl_str_mv TRASTORNO DEL ESPECTRO AUTISTA
COVID-19
SARS-CoV-2
MELATONINA
topic TRASTORNO DEL ESPECTRO AUTISTA
COVID-19
SARS-CoV-2
MELATONINA
dc.description.none.fl_txt_mv Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; Canadá
Fil: Karthikeyan, Ramanujam. Investigador independiente; India
Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultaf de Ciencias Médicas; Argentina
Abstract: Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reported that many of those with ASD have substantial sleep disorders with low levels of melatonin and various genetic alterations related to melatonin production have been found. Several lines of evidence point to a substantial role of melatonin in the body’s innate defense system including acting as a scavenger, an antioxidant and modulating the immune system. We therefore hypothesize that melatonin deficiency may predispose those ASD patients who have low melatonin output to COVID-19 disease. Potential implications for treatment are discussed.
description Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; Canadá
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/18344
0306-9877
10.1016/j.mehy.2021.110544
Brown, G. M. et al. Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin [en línea]. Medical Hypotheses. 2021, 149 . doi: 10.1016/j.mehy.2021.110544. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18344
url https://repositorio.uca.edu.ar/handle/123456789/18344
identifier_str_mv 0306-9877
10.1016/j.mehy.2021.110544
Brown, G. M. et al. Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin [en línea]. Medical Hypotheses. 2021, 149 . doi: 10.1016/j.mehy.2021.110544. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18344
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Medical Hypotheses. 2021, 149
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 12.982451

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