Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
- Autores
- Cha, Hye Lim; Choi, Jung-Mi; Oh, Huy-Hyen; Bashyal, Narayan; Kim, Sung-Soo; Birnbaumer, Lutz; Suh-Kim, Haeyoung
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Cha, Hye Lim. Ajou University School of Medicine. Departments of Anatomy; South Korea
Fil: Choi, Jung-Mi. Ajou University School of Medicine. Departments of Anatomy; South Korea
Fil: Oh, Huy-Hyen. Ajou University School of Medicine. Departments of Anatomy; South Korea
Fil: Bashyal, Narayan. Ajou University School of Medicine. Departments of Anatomy; South Korea
Fil: Bashyal, Narayan. Ajou University School of Medicine. The Graduate School. Departments of Biomedical Sciences; South Korea
Fil: Kim, Sung-Soo. Ajou University School of Medicine. Departments of Anatomy; South Korea
Fil: Birnbaumer, Lutz. Pontificia Univerisdad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Departments of Anatomy; South Korea
Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Departments of Anatomy; South Korea
Abtract: Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deleting its gene, Gnao. We performed a histological analysis with cerebellar sections of adult mice by cresyl violet- and immunostaining. Global deletion of Gnao induced cerebellar hypoplasia, reduced arborization of Purkinje cell dendrites, and atrophied Purkinje cell dendritic spines and the terminal boutons of climbing fibers from the inferior olivary nucleus. These results indicate that Go-mediated signaling pathway regulates maturation of presynaptic parallel fibers from granule cells and climbing fibers during the cerebellar cortical development. - Fuente
- Molecular Brain. 2019;12(1):57
- Materia
-
SISTEMA NERVIOSO CENTRAL
CEREBELO
PROTEINAS
HIPOPLASIA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/8680
Ver los metadatos del registro completo
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Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in miceCha, Hye LimChoi, Jung-MiOh, Huy-HyenBashyal, NarayanKim, Sung-SooBirnbaumer, LutzSuh-Kim, HaeyoungSISTEMA NERVIOSO CENTRALCEREBELOPROTEINASHIPOPLASIAFil: Cha, Hye Lim. Ajou University School of Medicine. Departments of Anatomy; South KoreaFil: Choi, Jung-Mi. Ajou University School of Medicine. Departments of Anatomy; South KoreaFil: Oh, Huy-Hyen. Ajou University School of Medicine. Departments of Anatomy; South KoreaFil: Bashyal, Narayan. Ajou University School of Medicine. Departments of Anatomy; South KoreaFil: Bashyal, Narayan. Ajou University School of Medicine. The Graduate School. Departments of Biomedical Sciences; South KoreaFil: Kim, Sung-Soo. Ajou University School of Medicine. Departments of Anatomy; South KoreaFil: Birnbaumer, Lutz. Pontificia Univerisdad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados UnidosFil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Departments of Anatomy; South KoreaFil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Departments of Anatomy; South KoreaAbtract: Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deleting its gene, Gnao. We performed a histological analysis with cerebellar sections of adult mice by cresyl violet- and immunostaining. Global deletion of Gnao induced cerebellar hypoplasia, reduced arborization of Purkinje cell dendrites, and atrophied Purkinje cell dendritic spines and the terminal boutons of climbing fibers from the inferior olivary nucleus. These results indicate that Go-mediated signaling pathway regulates maturation of presynaptic parallel fibers from granule cells and climbing fibers during the cerebellar cortical development.BMC2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/86801756-660610.1186/s13041-019-0477-931221179Cha HL, Choi J-M, Oh H-H, et al. Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice [en línea]. Molecular Brain. 2019;12(1):57. doi:10.1186/s13041-019-0477-9 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8680Molecular Brain. 2019;12(1):57reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:54Zoai:ucacris:123456789/8680instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:54.99Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice |
title |
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice |
spellingShingle |
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice Cha, Hye Lim SISTEMA NERVIOSO CENTRAL CEREBELO PROTEINAS HIPOPLASIA |
title_short |
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice |
title_full |
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice |
title_fullStr |
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice |
title_full_unstemmed |
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice |
title_sort |
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice |
dc.creator.none.fl_str_mv |
Cha, Hye Lim Choi, Jung-Mi Oh, Huy-Hyen Bashyal, Narayan Kim, Sung-Soo Birnbaumer, Lutz Suh-Kim, Haeyoung |
author |
Cha, Hye Lim |
author_facet |
Cha, Hye Lim Choi, Jung-Mi Oh, Huy-Hyen Bashyal, Narayan Kim, Sung-Soo Birnbaumer, Lutz Suh-Kim, Haeyoung |
author_role |
author |
author2 |
Choi, Jung-Mi Oh, Huy-Hyen Bashyal, Narayan Kim, Sung-Soo Birnbaumer, Lutz Suh-Kim, Haeyoung |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
SISTEMA NERVIOSO CENTRAL CEREBELO PROTEINAS HIPOPLASIA |
topic |
SISTEMA NERVIOSO CENTRAL CEREBELO PROTEINAS HIPOPLASIA |
dc.description.none.fl_txt_mv |
Fil: Cha, Hye Lim. Ajou University School of Medicine. Departments of Anatomy; South Korea Fil: Choi, Jung-Mi. Ajou University School of Medicine. Departments of Anatomy; South Korea Fil: Oh, Huy-Hyen. Ajou University School of Medicine. Departments of Anatomy; South Korea Fil: Bashyal, Narayan. Ajou University School of Medicine. Departments of Anatomy; South Korea Fil: Bashyal, Narayan. Ajou University School of Medicine. The Graduate School. Departments of Biomedical Sciences; South Korea Fil: Kim, Sung-Soo. Ajou University School of Medicine. Departments of Anatomy; South Korea Fil: Birnbaumer, Lutz. Pontificia Univerisdad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Departments of Anatomy; South Korea Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Departments of Anatomy; South Korea Abtract: Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deleting its gene, Gnao. We performed a histological analysis with cerebellar sections of adult mice by cresyl violet- and immunostaining. Global deletion of Gnao induced cerebellar hypoplasia, reduced arborization of Purkinje cell dendrites, and atrophied Purkinje cell dendritic spines and the terminal boutons of climbing fibers from the inferior olivary nucleus. These results indicate that Go-mediated signaling pathway regulates maturation of presynaptic parallel fibers from granule cells and climbing fibers during the cerebellar cortical development. |
description |
Fil: Cha, Hye Lim. Ajou University School of Medicine. Departments of Anatomy; South Korea |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/8680 1756-6606 10.1186/s13041-019-0477-9 31221179 Cha HL, Choi J-M, Oh H-H, et al. Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice [en línea]. Molecular Brain. 2019;12(1):57. doi:10.1186/s13041-019-0477-9 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8680 |
url |
https://repositorio.uca.edu.ar/handle/123456789/8680 |
identifier_str_mv |
1756-6606 10.1186/s13041-019-0477-9 31221179 Cha HL, Choi J-M, Oh H-H, et al. Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice [en línea]. Molecular Brain. 2019;12(1):57. doi:10.1186/s13041-019-0477-9 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8680 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMC |
publisher.none.fl_str_mv |
BMC |
dc.source.none.fl_str_mv |
Molecular Brain. 2019;12(1):57 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638347478433792 |
score |
13.13397 |