Melatonin, mitochondria, and the metabolic syndrome

Autores
Cardinali, Daniel Pedro; Vigo, Daniel Eduardo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed.
Fuente
Preprint del documento publicado en Cellular and Molecular Life Sciences Vol. 74, Nº 21, 2017
Materia
MEDICINA
MELATONINA
DIABETES
OBESIDAD
SINDROME METABOLICO
MITOCONDRIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1458
Acceder
id RIUCA_f5d1cb4de70f7ce44a6a2386f1e73364
oai_identifier_str oai:ucacris:123456789/1458
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Melatonin, mitochondria, and the metabolic syndromeCardinali, Daniel PedroVigo, Daniel EduardoMEDICINAMELATONINADIABETESOBESIDADSINDROME METABOLICOMITOCONDRIAFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed.Springer International Publishing2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/14581420-682X (impreso)1420-9071 (online)10.1007/s00018-017-2611-028819865Cardinali, D. P., Vigo, D. E. Melatonin, mitochondria, and the metabolic syndrome [en línea]. Preprint del documento publicado en Cellular and Molecular Life Sciences. 2017, 74 (21). doi: 10.1007/s00018-017-2611-0. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1458Preprint del documento publicado en Cellular and Molecular Life Sciences Vol. 74, Nº 21, 2017reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:17Zoai:ucacris:123456789/1458instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:17.928Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Melatonin, mitochondria, and the metabolic syndrome
title Melatonin, mitochondria, and the metabolic syndrome
spellingShingle Melatonin, mitochondria, and the metabolic syndrome
Cardinali, Daniel Pedro
MEDICINA
MELATONINA
DIABETES
OBESIDAD
SINDROME METABOLICO
MITOCONDRIA
title_short Melatonin, mitochondria, and the metabolic syndrome
title_full Melatonin, mitochondria, and the metabolic syndrome
title_fullStr Melatonin, mitochondria, and the metabolic syndrome
title_full_unstemmed Melatonin, mitochondria, and the metabolic syndrome
title_sort Melatonin, mitochondria, and the metabolic syndrome
dc.creator.none.fl_str_mv Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
author_role author
author2 Vigo, Daniel Eduardo
author2_role author
dc.subject.none.fl_str_mv MEDICINA
MELATONINA
DIABETES
OBESIDAD
SINDROME METABOLICO
MITOCONDRIA
topic MEDICINA
MELATONINA
DIABETES
OBESIDAD
SINDROME METABOLICO
MITOCONDRIA
dc.description.none.fl_txt_mv Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed.
description Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1458
1420-682X (impreso)
1420-9071 (online)
10.1007/s00018-017-2611-0
28819865
Cardinali, D. P., Vigo, D. E. Melatonin, mitochondria, and the metabolic syndrome [en línea]. Preprint del documento publicado en Cellular and Molecular Life Sciences. 2017, 74 (21). doi: 10.1007/s00018-017-2611-0. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1458
url https://repositorio.uca.edu.ar/handle/123456789/1458
identifier_str_mv 1420-682X (impreso)
1420-9071 (online)
10.1007/s00018-017-2611-0
28819865
Cardinali, D. P., Vigo, D. E. Melatonin, mitochondria, and the metabolic syndrome [en línea]. Preprint del documento publicado en Cellular and Molecular Life Sciences. 2017, 74 (21). doi: 10.1007/s00018-017-2611-0. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1458
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer International Publishing
publisher.none.fl_str_mv Springer International Publishing
dc.source.none.fl_str_mv Preprint del documento publicado en Cellular and Molecular Life Sciences Vol. 74, Nº 21, 2017
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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