Management of constipation in Parkinson’s disease

Autores
Rossi, Marcelo; Merello, Marcelo; Pérez Lloret, Santiago
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Rossi, Marcelo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; Argentina
Fil: Rossi, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Merello, Marcelo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; Argentina
Fil: Merello, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract Introduction: Constipation is a frequent non-motor feature of Parkinson’s disease (PD). It is the most common gastrointestinal symptom of the disease and it can precede motor symptoms by as much as 20 years. Constipation can produce discomfort and affect activities of daily living, productivity and quality of life, thus warranting early diagnosis and treatment. Areas covered: In this review, the safety and efficacy of traditional and novel strategies for constipation management will be discussed. A treatment algorithm for constipation in PD will be presented. Expert opinion: Polyethylene glycol and lubiprostone are first-line compounds recommended by evidence-based medicine guidelines for the treatment of constipation due to slow colonic transit in PD. Management of constipation secondary to defecatory dysfunction due to pelvic floor dyssynergia can be done by levodopa or apomorphine injections, botulinum toxin type A injection into the puborectalis muscle, and nonpharmacological interventions, like biofeedback therapy or functional magnetic stimulation, which showed some benefit in PD patients with constipation, but in general more extensive studies are warranted.
Fuente
Expert Opinion on Pharmacotherapy . 2015, 16(4)
Materia
CONSTIPACION
TRANSTORNOS DIGESTIVOS
ENFERMEDAD DE PARKINSON
LAXANTES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/14250
Acceder
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oai_identifier_str oai:ucacris:123456789/14250
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Management of constipation in Parkinson’s diseaseRossi, MarceloMerello, MarceloPérez Lloret, SantiagoCONSTIPACIONTRANSTORNOS DIGESTIVOSENFERMEDAD DE PARKINSONLAXANTESFil: Rossi, Marcelo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; ArgentinaFil: Rossi, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Merello, Marcelo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; ArgentinaFil: Merello, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; ArgentinaFil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract Introduction: Constipation is a frequent non-motor feature of Parkinson’s disease (PD). It is the most common gastrointestinal symptom of the disease and it can precede motor symptoms by as much as 20 years. Constipation can produce discomfort and affect activities of daily living, productivity and quality of life, thus warranting early diagnosis and treatment. Areas covered: In this review, the safety and efficacy of traditional and novel strategies for constipation management will be discussed. A treatment algorithm for constipation in PD will be presented. Expert opinion: Polyethylene glycol and lubiprostone are first-line compounds recommended by evidence-based medicine guidelines for the treatment of constipation due to slow colonic transit in PD. Management of constipation secondary to defecatory dysfunction due to pelvic floor dyssynergia can be done by levodopa or apomorphine injections, botulinum toxin type A injection into the puborectalis muscle, and nonpharmacological interventions, like biofeedback therapy or functional magnetic stimulation, which showed some benefit in PD patients with constipation, but in general more extensive studies are warranted.Taylor & Francis2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/142501465-65661744-7666 (online)10.1517/14656566.2015.99721125539892Rossi, M. Merello, M., Pérez Lloret, S. Management of constipation in Parkinson’s disease [en línea]. Expert Opinion on Pharmacotherapy . 2015, 16(4). doi:10.1517/14656566.2015.997211 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14250Expert Opinion on Pharmacotherapy . 2015, 16(4)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:38Zoai:ucacris:123456789/14250instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:38.403Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Management of constipation in Parkinson’s disease
title Management of constipation in Parkinson’s disease
spellingShingle Management of constipation in Parkinson’s disease
Rossi, Marcelo
CONSTIPACION
TRANSTORNOS DIGESTIVOS
ENFERMEDAD DE PARKINSON
LAXANTES
title_short Management of constipation in Parkinson’s disease
title_full Management of constipation in Parkinson’s disease
title_fullStr Management of constipation in Parkinson’s disease
title_full_unstemmed Management of constipation in Parkinson’s disease
title_sort Management of constipation in Parkinson’s disease
dc.creator.none.fl_str_mv Rossi, Marcelo
Merello, Marcelo
Pérez Lloret, Santiago
author Rossi, Marcelo
author_facet Rossi, Marcelo
Merello, Marcelo
Pérez Lloret, Santiago
author_role author
author2 Merello, Marcelo
Pérez Lloret, Santiago
author2_role author
author
dc.subject.none.fl_str_mv CONSTIPACION
TRANSTORNOS DIGESTIVOS
ENFERMEDAD DE PARKINSON
LAXANTES
topic CONSTIPACION
TRANSTORNOS DIGESTIVOS
ENFERMEDAD DE PARKINSON
LAXANTES
dc.description.none.fl_txt_mv Fil: Rossi, Marcelo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; Argentina
Fil: Rossi, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Merello, Marcelo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; Argentina
Fil: Merello, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract Introduction: Constipation is a frequent non-motor feature of Parkinson’s disease (PD). It is the most common gastrointestinal symptom of the disease and it can precede motor symptoms by as much as 20 years. Constipation can produce discomfort and affect activities of daily living, productivity and quality of life, thus warranting early diagnosis and treatment. Areas covered: In this review, the safety and efficacy of traditional and novel strategies for constipation management will be discussed. A treatment algorithm for constipation in PD will be presented. Expert opinion: Polyethylene glycol and lubiprostone are first-line compounds recommended by evidence-based medicine guidelines for the treatment of constipation due to slow colonic transit in PD. Management of constipation secondary to defecatory dysfunction due to pelvic floor dyssynergia can be done by levodopa or apomorphine injections, botulinum toxin type A injection into the puborectalis muscle, and nonpharmacological interventions, like biofeedback therapy or functional magnetic stimulation, which showed some benefit in PD patients with constipation, but in general more extensive studies are warranted.
description Fil: Rossi, Marcelo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Epidemiología y Farmacología Experimental; Argentina
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/14250
1465-6566
1744-7666 (online)
10.1517/14656566.2015.997211
25539892
Rossi, M. Merello, M., Pérez Lloret, S. Management of constipation in Parkinson’s disease [en línea]. Expert Opinion on Pharmacotherapy . 2015, 16(4). doi:10.1517/14656566.2015.997211 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14250
url https://repositorio.uca.edu.ar/handle/123456789/14250
identifier_str_mv 1465-6566
1744-7666 (online)
10.1517/14656566.2015.997211
25539892
Rossi, M. Merello, M., Pérez Lloret, S. Management of constipation in Parkinson’s disease [en línea]. Expert Opinion on Pharmacotherapy . 2015, 16(4). doi:10.1517/14656566.2015.997211 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14250
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv Expert Opinion on Pharmacotherapy . 2015, 16(4)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.070432

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