Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease

Autores
Abulafia, Carolina Andrea; Loewenstein, David A.; Curiel-Cid, Rosie; Duarte-Abritta, Bárbara; Sánchez, Stella M.; Vigo, Daniel Eduardo; Castro, Mariana N.; Drucaroff, Lucas J.; Vázquez, Silvia; Sevlever, Gustavo; Nemeroff, Charles B.; Guinjoan, Salvador M.; Villareal, Mirta F.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Fil: Abulafia, Carolina. Fundación Fleni; Argentina
Fil: Abulafia, Carolina. Pontificia Universidad Católica Argentina. Insituto de Investigaciones Biomédicas; Argentina
Fil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Loewenstein, David A. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidos
Fil: Curiel-Cid, Rosie. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidos
Fil: Duarte-Abritta, Bárbara. Fundación Fleni; Argentina
Fil: Sánchez, Stella M. Fundación Fleni; Argentina
Fil: Sánchez, Stella M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sánchez, Stella M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Na Departamento de Física; Argentina
Fil:Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Insituto de Investigaciones Biomédicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Mariana N. Fundación Fleni; Argentina
Fil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina
Fil: Drucaroff, Lucas J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Drucaroff, Lucas J. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina
Fil: Vázquez, Silvia. Fundación Fleni; Argentina
Fil: Sevlever, Gustavo. Fundación Fleni; Argentina
Fil: Nemeroff, Charles B. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidos
Fil: Guinjoan, Salvador M. Fundación Fleni; Argentina
Fil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villareal, Mirta F. Fundación Fleni; Argentina
Fil: Villareal, Mirta F. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villareal, Mirta F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Abstract: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer’s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer’s disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer’s-relevant brain regions even at a relatively young age.
Fuente
Postprint de artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1)
Materia
MEDICINA
ENFERMEDAD DE ALZHEIMER
MEMORIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1437
Acceder
id RIUCA_1875068b1c4c8e3212bedc7400cfca8c
oai_identifier_str oai:ucacris:123456789/1437
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's diseaseAbulafia, Carolina AndreaLoewenstein, David A.Curiel-Cid, RosieDuarte-Abritta, BárbaraSánchez, Stella M.Vigo, Daniel EduardoCastro, Mariana N.Drucaroff, Lucas J.Vázquez, SilviaSevlever, GustavoNemeroff, Charles B.Guinjoan, Salvador M.Villareal, Mirta F.MEDICINAENFERMEDAD DE ALZHEIMERMEMORIAFil: Abulafia, Carolina. Fundación Fleni; ArgentinaFil: Abulafia, Carolina. Pontificia Universidad Católica Argentina. Insituto de Investigaciones Biomédicas; ArgentinaFil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Loewenstein, David A. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados UnidosFil: Curiel-Cid, Rosie. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados UnidosFil: Duarte-Abritta, Bárbara. Fundación Fleni; ArgentinaFil: Sánchez, Stella M. Fundación Fleni; ArgentinaFil: Sánchez, Stella M. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sánchez, Stella M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Na Departamento de Física; ArgentinaFil:Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Insituto de Investigaciones Biomédicas; ArgentinaFil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castro, Mariana N. Fundación Fleni; ArgentinaFil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; ArgentinaFil: Drucaroff, Lucas J. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Drucaroff, Lucas J. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; ArgentinaFil: Vázquez, Silvia. Fundación Fleni; ArgentinaFil: Sevlever, Gustavo. Fundación Fleni; ArgentinaFil: Nemeroff, Charles B. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados UnidosFil: Guinjoan, Salvador M. Fundación Fleni; ArgentinaFil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Villareal, Mirta F. Fundación Fleni; ArgentinaFil: Villareal, Mirta F. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Villareal, Mirta F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaAbstract: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer’s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer’s disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer’s-relevant brain regions even at a relatively young age.American Psychiatric Association2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/14371545-7222 (online)10.1176/appi.neuropsych.17120355Abulafia, C., et al. Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease [en línea]. Postprint del artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1). doi:10.1176/appi.neuropsych.17120355. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1437Postprint de artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:17Zoai:ucacris:123456789/1437instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:17.864Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
spellingShingle Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
Abulafia, Carolina Andrea
MEDICINA
ENFERMEDAD DE ALZHEIMER
MEMORIA
title_short Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_full Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_fullStr Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_full_unstemmed Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_sort Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
dc.creator.none.fl_str_mv Abulafia, Carolina Andrea
Loewenstein, David A.
Curiel-Cid, Rosie
Duarte-Abritta, Bárbara
Sánchez, Stella M.
Vigo, Daniel Eduardo
Castro, Mariana N.
Drucaroff, Lucas J.
Vázquez, Silvia
Sevlever, Gustavo
Nemeroff, Charles B.
Guinjoan, Salvador M.
Villareal, Mirta F.
author Abulafia, Carolina Andrea
author_facet Abulafia, Carolina Andrea
Loewenstein, David A.
Curiel-Cid, Rosie
Duarte-Abritta, Bárbara
Sánchez, Stella M.
Vigo, Daniel Eduardo
Castro, Mariana N.
Drucaroff, Lucas J.
Vázquez, Silvia
Sevlever, Gustavo
Nemeroff, Charles B.
Guinjoan, Salvador M.
Villareal, Mirta F.
author_role author
author2 Loewenstein, David A.
Curiel-Cid, Rosie
Duarte-Abritta, Bárbara
Sánchez, Stella M.
Vigo, Daniel Eduardo
Castro, Mariana N.
Drucaroff, Lucas J.
Vázquez, Silvia
Sevlever, Gustavo
Nemeroff, Charles B.
Guinjoan, Salvador M.
Villareal, Mirta F.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MEDICINA
ENFERMEDAD DE ALZHEIMER
MEMORIA
topic MEDICINA
ENFERMEDAD DE ALZHEIMER
MEMORIA
dc.description.none.fl_txt_mv Fil: Abulafia, Carolina. Fundación Fleni; Argentina
Fil: Abulafia, Carolina. Pontificia Universidad Católica Argentina. Insituto de Investigaciones Biomédicas; Argentina
Fil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Loewenstein, David A. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidos
Fil: Curiel-Cid, Rosie. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidos
Fil: Duarte-Abritta, Bárbara. Fundación Fleni; Argentina
Fil: Sánchez, Stella M. Fundación Fleni; Argentina
Fil: Sánchez, Stella M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sánchez, Stella M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Na Departamento de Física; Argentina
Fil:Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Insituto de Investigaciones Biomédicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Mariana N. Fundación Fleni; Argentina
Fil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina
Fil: Drucaroff, Lucas J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Drucaroff, Lucas J. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina
Fil: Vázquez, Silvia. Fundación Fleni; Argentina
Fil: Sevlever, Gustavo. Fundación Fleni; Argentina
Fil: Nemeroff, Charles B. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidos
Fil: Guinjoan, Salvador M. Fundación Fleni; Argentina
Fil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villareal, Mirta F. Fundación Fleni; Argentina
Fil: Villareal, Mirta F. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villareal, Mirta F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Abstract: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer’s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer’s disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer’s-relevant brain regions even at a relatively young age.
description Fil: Abulafia, Carolina. Fundación Fleni; Argentina
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1437
1545-7222 (online)
10.1176/appi.neuropsych.17120355
Abulafia, C., et al. Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease [en línea]. Postprint del artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1). doi:10.1176/appi.neuropsych.17120355. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1437
url https://repositorio.uca.edu.ar/handle/123456789/1437
identifier_str_mv 1545-7222 (online)
10.1176/appi.neuropsych.17120355
Abulafia, C., et al. Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease [en línea]. Postprint del artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1). doi:10.1176/appi.neuropsych.17120355. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1437
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Psychiatric Association
publisher.none.fl_str_mv American Psychiatric Association
dc.source.none.fl_str_mv Postprint de artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.22299

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