New concepts in the neurophysiology of sleep and wakefulness
- Autores
- Garay, Arturo; Cardinali, Daniel Pedro
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Garay, Arturo. Hospital Universitario. Sección Medicina del Sueño. Unidad de Neurociencia; Argentina
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Abstract: The neural substrates of sleep and wakefulness form a highly distributed and, to some extent, redundant network, with hypocretin, monoaminergic and cholinergic systems largely promoting wakefulness and GABAergic systems in the preoptic area, hypothalamus and brainstem promoting sleep. The hypocretin/orexin system plays a special role in the promotion of wakefulness and suppression of REM sleep by providing excitatory input to the monoaminergic and cholinergic systems. Sleep is not a unitary state but involves a cyclic alternation between NREM and REM sleep; the pons is critical for generating the multiple components (ie, EEG synchronization, eye movements and muscle atonia) that characterize REM sleep. Recent findings have implicated the participation of hypothalamus, through MCH/GABA that provide a critical input to pontine generator of REM sleep. The timing of sleep and wakefulness is regulated by an interaction between the circadian pacemaker located in the hypothalamic SCN and a sleep homeostatic system whose anatomic location is yet to be definitively identified. Among various neurochemicals, extracellular AD and nNOS/NK1 accumulate in the BF as wakefulness is extended and inhibits cortically projecting cholinergic neurons, thereby influencing cortical activity. In the future, it seems reasonable to expect a spreading of these insights from basic to clinical grounds for a better understanding of the causes and mechanisms of sleep disorders and the generation of novel therapeutics in sleep medicine. - Fuente
- Physiological Mini Reviews, Vol. 9, N° 3, 2016
ISSN 1669-5410 (Online) - Materia
-
MEDICINA
SUEÑO
FISIOLOGIA
RITMO CIRCADIANO - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/1447
Ver los metadatos del registro completo
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New concepts in the neurophysiology of sleep and wakefulnessGaray, ArturoCardinali, Daniel PedroMEDICINASUEÑOFISIOLOGIARITMO CIRCADIANOFil: Garay, Arturo. Hospital Universitario. Sección Medicina del Sueño. Unidad de Neurociencia; ArgentinaFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaAbstract: The neural substrates of sleep and wakefulness form a highly distributed and, to some extent, redundant network, with hypocretin, monoaminergic and cholinergic systems largely promoting wakefulness and GABAergic systems in the preoptic area, hypothalamus and brainstem promoting sleep. The hypocretin/orexin system plays a special role in the promotion of wakefulness and suppression of REM sleep by providing excitatory input to the monoaminergic and cholinergic systems. Sleep is not a unitary state but involves a cyclic alternation between NREM and REM sleep; the pons is critical for generating the multiple components (ie, EEG synchronization, eye movements and muscle atonia) that characterize REM sleep. Recent findings have implicated the participation of hypothalamus, through MCH/GABA that provide a critical input to pontine generator of REM sleep. The timing of sleep and wakefulness is regulated by an interaction between the circadian pacemaker located in the hypothalamic SCN and a sleep homeostatic system whose anatomic location is yet to be definitively identified. Among various neurochemicals, extracellular AD and nNOS/NK1 accumulate in the BF as wakefulness is extended and inhibits cortically projecting cholinergic neurons, thereby influencing cortical activity. In the future, it seems reasonable to expect a spreading of these insights from basic to clinical grounds for a better understanding of the causes and mechanisms of sleep disorders and the generation of novel therapeutics in sleep medicine.Sociedad Argentina de Fisiología2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/14471669-5410 (online)Garay A., Cardinali, D. P. New concepts in the neurophysiology of sleep and wakefulness [en línea]. Physiological Mini Reviews. 2016, 9 (3). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1447Physiological Mini Reviews, Vol. 9, N° 3, 2016ISSN 1669-5410 (Online)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:17Zoai:ucacris:123456789/1447instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:17.893Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
New concepts in the neurophysiology of sleep and wakefulness |
title |
New concepts in the neurophysiology of sleep and wakefulness |
spellingShingle |
New concepts in the neurophysiology of sleep and wakefulness Garay, Arturo MEDICINA SUEÑO FISIOLOGIA RITMO CIRCADIANO |
title_short |
New concepts in the neurophysiology of sleep and wakefulness |
title_full |
New concepts in the neurophysiology of sleep and wakefulness |
title_fullStr |
New concepts in the neurophysiology of sleep and wakefulness |
title_full_unstemmed |
New concepts in the neurophysiology of sleep and wakefulness |
title_sort |
New concepts in the neurophysiology of sleep and wakefulness |
dc.creator.none.fl_str_mv |
Garay, Arturo Cardinali, Daniel Pedro |
author |
Garay, Arturo |
author_facet |
Garay, Arturo Cardinali, Daniel Pedro |
author_role |
author |
author2 |
Cardinali, Daniel Pedro |
author2_role |
author |
dc.subject.none.fl_str_mv |
MEDICINA SUEÑO FISIOLOGIA RITMO CIRCADIANO |
topic |
MEDICINA SUEÑO FISIOLOGIA RITMO CIRCADIANO |
dc.description.none.fl_txt_mv |
Fil: Garay, Arturo. Hospital Universitario. Sección Medicina del Sueño. Unidad de Neurociencia; Argentina Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina Abstract: The neural substrates of sleep and wakefulness form a highly distributed and, to some extent, redundant network, with hypocretin, monoaminergic and cholinergic systems largely promoting wakefulness and GABAergic systems in the preoptic area, hypothalamus and brainstem promoting sleep. The hypocretin/orexin system plays a special role in the promotion of wakefulness and suppression of REM sleep by providing excitatory input to the monoaminergic and cholinergic systems. Sleep is not a unitary state but involves a cyclic alternation between NREM and REM sleep; the pons is critical for generating the multiple components (ie, EEG synchronization, eye movements and muscle atonia) that characterize REM sleep. Recent findings have implicated the participation of hypothalamus, through MCH/GABA that provide a critical input to pontine generator of REM sleep. The timing of sleep and wakefulness is regulated by an interaction between the circadian pacemaker located in the hypothalamic SCN and a sleep homeostatic system whose anatomic location is yet to be definitively identified. Among various neurochemicals, extracellular AD and nNOS/NK1 accumulate in the BF as wakefulness is extended and inhibits cortically projecting cholinergic neurons, thereby influencing cortical activity. In the future, it seems reasonable to expect a spreading of these insights from basic to clinical grounds for a better understanding of the causes and mechanisms of sleep disorders and the generation of novel therapeutics in sleep medicine. |
description |
Fil: Garay, Arturo. Hospital Universitario. Sección Medicina del Sueño. Unidad de Neurociencia; Argentina |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/1447 1669-5410 (online) Garay A., Cardinali, D. P. New concepts in the neurophysiology of sleep and wakefulness [en línea]. Physiological Mini Reviews. 2016, 9 (3). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1447 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1447 |
identifier_str_mv |
1669-5410 (online) Garay A., Cardinali, D. P. New concepts in the neurophysiology of sleep and wakefulness [en línea]. Physiological Mini Reviews. 2016, 9 (3). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1447 |
dc.language.none.fl_str_mv |
eng eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedad Argentina de Fisiología |
publisher.none.fl_str_mv |
Sociedad Argentina de Fisiología |
dc.source.none.fl_str_mv |
Physiological Mini Reviews, Vol. 9, N° 3, 2016 ISSN 1669-5410 (Online) reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638330118209536 |
score |
13.13397 |