The contribution of biophysics and structural biology to current advances in COVID-19
- Autores
- Barrantes, Francisco José
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membraneboundmetalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies. - Fuente
- Annual Review of Biophysics. 2021, 50
- Materia
-
COVID-19
PROTEINAS
ESTRUCTURA MOLECULAR
BIOFISICA
BIOLOGIA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/14239
Ver los metadatos del registro completo
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The contribution of biophysics and structural biology to current advances in COVID-19Barrantes, Francisco JoséCOVID-19PROTEINASESTRUCTURA MOLECULARBIOFISICABIOLOGIAFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membraneboundmetalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies.Annual Reviews2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/142391936-122X10.1146/annurev-biophys-102620-08095633957057Barrantes, F.J. The contribution of biophysics and structural biology to current advances in COVID-19 [en línea]. Annual Review of Biophysics. 2021, 50 doi:10.1146/annurev-biophys-102620-080956 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14239Annual Review of Biophysics. 2021, 50reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:38Zoai:ucacris:123456789/14239instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:38.372Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
The contribution of biophysics and structural biology to current advances in COVID-19 |
title |
The contribution of biophysics and structural biology to current advances in COVID-19 |
spellingShingle |
The contribution of biophysics and structural biology to current advances in COVID-19 Barrantes, Francisco José COVID-19 PROTEINAS ESTRUCTURA MOLECULAR BIOFISICA BIOLOGIA |
title_short |
The contribution of biophysics and structural biology to current advances in COVID-19 |
title_full |
The contribution of biophysics and structural biology to current advances in COVID-19 |
title_fullStr |
The contribution of biophysics and structural biology to current advances in COVID-19 |
title_full_unstemmed |
The contribution of biophysics and structural biology to current advances in COVID-19 |
title_sort |
The contribution of biophysics and structural biology to current advances in COVID-19 |
dc.creator.none.fl_str_mv |
Barrantes, Francisco José |
author |
Barrantes, Francisco José |
author_facet |
Barrantes, Francisco José |
author_role |
author |
dc.subject.none.fl_str_mv |
COVID-19 PROTEINAS ESTRUCTURA MOLECULAR BIOFISICA BIOLOGIA |
topic |
COVID-19 PROTEINAS ESTRUCTURA MOLECULAR BIOFISICA BIOLOGIA |
dc.description.none.fl_txt_mv |
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Abstract: Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membraneboundmetalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies. |
description |
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/14239 1936-122X 10.1146/annurev-biophys-102620-080956 33957057 Barrantes, F.J. The contribution of biophysics and structural biology to current advances in COVID-19 [en línea]. Annual Review of Biophysics. 2021, 50 doi:10.1146/annurev-biophys-102620-080956 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14239 |
url |
https://repositorio.uca.edu.ar/handle/123456789/14239 |
identifier_str_mv |
1936-122X 10.1146/annurev-biophys-102620-080956 33957057 Barrantes, F.J. The contribution of biophysics and structural biology to current advances in COVID-19 [en línea]. Annual Review of Biophysics. 2021, 50 doi:10.1146/annurev-biophys-102620-080956 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14239 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Annual Reviews |
publisher.none.fl_str_mv |
Annual Reviews |
dc.source.none.fl_str_mv |
Annual Review of Biophysics. 2021, 50 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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score |
13.070432 |