Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease

Authors
Abulafia, Carolina Andrea; Duarte Abritta, Bárbara; Villarreal, Mirta Fabiana; Ladrón de Guevara, Maria Soledad; Garcia, Maria Celeste; Sequeyra, Geraldine; Sevlever, Gustavo; Fiorentini, Leticia; Bär, Karl-Jürgen; Gustafson, Deborah; Vigo, Daniel Eduardo; Guinjoan, Salvador Martín
Publication Year
2017
Language
English
Format
article
Status
Published version
Description
Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina ; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Duarte Abritta, Bárbara. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Ladrón de Guevara, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Garcia, Maria Celeste. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sequeyra, Geraldine. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sevlever, Gustavo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Fiorentini, Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
Fil: Gustafson, Deborah. State University of New York; Estados Unidos. University Goteborg; Suecia. University of Skövde; Suecia
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina ; Argentina
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina
Subject
ACTIGRAPHY
CARDIAC AUTONOMIC CONTROL
CIRCADIAN RHYTHMS
EARLY DIAGNOSIS
LATE-ONSET ALZHEIMER'S DISEASE
Inmunología
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/54307