Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease

Autores
Abulafia, Carolina Andrea; Duarte Abritta, Bárbara; Villarreal, Mirta Fabiana; Ladrón de Guevara, Maria Soledad; Garcia, Maria Celeste; Sequeyra, Geraldine; Sevlever, Gustavo; Fiorentini, Leticia; Bär, Karl-Jürgen; Gustafson, Deborah; Vigo, Daniel Eduardo; Guinjoan, Salvador Martín
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina ; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Duarte Abritta, Bárbara. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Ladrón de Guevara, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Garcia, Maria Celeste. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sequeyra, Geraldine. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sevlever, Gustavo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Fiorentini, Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
Fil: Gustafson, Deborah. State University of New York; Estados Unidos. University Goteborg; Suecia. University of Skövde; Suecia
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina ; Argentina
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina
Materia
ACTIGRAPHY
CARDIAC AUTONOMIC CONTROL
CIRCADIAN RHYTHMS
EARLY DIAGNOSIS
LATE-ONSET ALZHEIMER'S DISEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/54307
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/54307
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s diseaseAbulafia, Carolina AndreaDuarte Abritta, BárbaraVillarreal, Mirta FabianaLadrón de Guevara, Maria SoledadGarcia, Maria CelesteSequeyra, GeraldineSevlever, GustavoFiorentini, LeticiaBär, Karl-JürgenGustafson, DeborahVigo, Daniel EduardoGuinjoan, Salvador MartínACTIGRAPHYCARDIAC AUTONOMIC CONTROLCIRCADIAN RHYTHMSEARLY DIAGNOSISLATE-ONSET ALZHEIMER'S DISEASEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina ; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Duarte Abritta, Bárbara. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Ladrón de Guevara, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Garcia, Maria Celeste. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Sequeyra, Geraldine. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Sevlever, Gustavo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Fiorentini, Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Bär, Karl-Jürgen. Universitat Jena; AlemaniaFil: Gustafson, Deborah. State University of New York; Estados Unidos. University Goteborg; Suecia. University of Skövde; SueciaFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina ; ArgentinaFil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; ArgentinaFrontiers Research Foundation2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/54307Abulafia, Carolina Andrea; Duarte Abritta, Bárbara; Villarreal, Mirta Fabiana; Ladrón de Guevara, Maria Soledad; Garcia, Maria Celeste; et al.; Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease; Frontiers Research Foundation; Frontiers in Aging Neuroscience; 9; 93; 4-2017; 1-81663-4365CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fnagi.2017.00093/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnagi.2017.00093info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:34Zoai:ri.conicet.gov.ar:11336/54307instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:34.96CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease
title Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease
spellingShingle Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease
Abulafia, Carolina Andrea
ACTIGRAPHY
CARDIAC AUTONOMIC CONTROL
CIRCADIAN RHYTHMS
EARLY DIAGNOSIS
LATE-ONSET ALZHEIMER'S DISEASE
title_short Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease
title_full Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease
title_fullStr Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease
title_full_unstemmed Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease
title_sort Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease
dc.creator.none.fl_str_mv Abulafia, Carolina Andrea
Duarte Abritta, Bárbara
Villarreal, Mirta Fabiana
Ladrón de Guevara, Maria Soledad
Garcia, Maria Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah
Vigo, Daniel Eduardo
Guinjoan, Salvador Martín
author Abulafia, Carolina Andrea
author_facet Abulafia, Carolina Andrea
Duarte Abritta, Bárbara
Villarreal, Mirta Fabiana
Ladrón de Guevara, Maria Soledad
Garcia, Maria Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah
Vigo, Daniel Eduardo
Guinjoan, Salvador Martín
author_role author
author2 Duarte Abritta, Bárbara
Villarreal, Mirta Fabiana
Ladrón de Guevara, Maria Soledad
Garcia, Maria Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah
Vigo, Daniel Eduardo
Guinjoan, Salvador Martín
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACTIGRAPHY
CARDIAC AUTONOMIC CONTROL
CIRCADIAN RHYTHMS
EARLY DIAGNOSIS
LATE-ONSET ALZHEIMER'S DISEASE
topic ACTIGRAPHY
CARDIAC AUTONOMIC CONTROL
CIRCADIAN RHYTHMS
EARLY DIAGNOSIS
LATE-ONSET ALZHEIMER'S DISEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina ; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Duarte Abritta, Bárbara. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Ladrón de Guevara, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Garcia, Maria Celeste. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sequeyra, Geraldine. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sevlever, Gustavo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Fiorentini, Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
Fil: Gustafson, Deborah. State University of New York; Estados Unidos. University Goteborg; Suecia. University of Skövde; Suecia
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina ; Argentina
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurociencias; Argentina
description Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/54307
Abulafia, Carolina Andrea; Duarte Abritta, Bárbara; Villarreal, Mirta Fabiana; Ladrón de Guevara, Maria Soledad; Garcia, Maria Celeste; et al.; Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease; Frontiers Research Foundation; Frontiers in Aging Neuroscience; 9; 93; 4-2017; 1-8
1663-4365
CONICET Digital
CONICET
url http://hdl.handle.net/11336/54307
identifier_str_mv Abulafia, Carolina Andrea; Duarte Abritta, Bárbara; Villarreal, Mirta Fabiana; Ladrón de Guevara, Maria Soledad; Garcia, Maria Celeste; et al.; Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease; Frontiers Research Foundation; Frontiers in Aging Neuroscience; 9; 93; 4-2017; 1-8
1663-4365
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fnagi.2017.00093/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fnagi.2017.00093
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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