Melatonin-induced oncostasis, mechanisms and clinical relevance

Autores
Cardinali, Daniel Pedro; Escames, Germaine; Acuña Castroviejo, D.; Ortiz, Francisco; Fernández Gil, Beatriz; Guerra Librero, Ana; García López, Sergio; Shen, Ying; Florido, Javier
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Escames, Germaine. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Escames, Germaine. Universidad de Granada. Facultad de Medicina. Departamento de Fisiología; España
Fil: Acuña-Castroviejo, Darío. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Acuña-Castroviejo, Darío. Universidad de Granada. Facultad de Medicina. Departamento de Fisiología; España
Fil: Ortiz, Francisco. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Fernández-Gil, Beatriz. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Guerra Librero, Ana. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: García-López, Sergio. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Shen, Ying. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Florido, Javier. Universidad de Granada. Centro de Investigación Biomédica; España
Abstract: Melatonin is a natural substance ubiquitously distributed and present in almost all living species, from unicellular organisms to humans. Melatonin is synthesized not only in the pineal gland but also in most tissues in the body where it may have a cytoprotective function via paracrine or autocrine effects. Melatonin is effective in suppressing neoplastic growth in a variety of tumors. The mechanisms involved include antiproliferative effects via modulation of cell cycle, ability to induce apoptosis in cancer cells, anti-angiogenic and antimetastatic effects, anti-estrogenic activity, the capacity to decrease telomerase activity, immune modulation, and direct and indirect antioxidant effects. Besides these oncostatic properties, melatonin deserves to be considered in the treatment of cancer for two other reasons. First, because its hypnotic-chronobiotic properties, melatonin use that can allow the clinician to effectively address sleep disturbances, a major co-morbidity in cancer. Second, because melatonin’s anxiolytic and antidepressant effects, it has a possible application in two other major co-morbidities seen in cancer patients, i.e. depression and anxiety. This report summarizes the possible mechanisms involved in melatonin oncostasis and reviews what is known about the clinical application of melatonin as an adjuvant therapy in cancer patients.
Fuente
Journal of Integrative Oncology, 2016, S1
ISSN 2329-6771
Materia
BIOMEDICINA
MEDICINA
MELATONINA
CANCER
TUMORES
METASTASIS
APOPTOSIS
INMUNOLOGIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1446
Acceder
id RIUCA_05257e5cdf81e98b1728fb6b082d1e16
oai_identifier_str oai:ucacris:123456789/1446
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Melatonin-induced oncostasis, mechanisms and clinical relevanceCardinali, Daniel PedroEscames, GermaineAcuña Castroviejo, D.Ortiz, FranciscoFernández Gil, BeatrizGuerra Librero, AnaGarcía López, SergioShen, YingFlorido, JavierBIOMEDICINAMEDICINAMELATONINACANCERTUMORESMETASTASISAPOPTOSISINMUNOLOGIAFil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Escames, Germaine. Universidad de Granada. Centro de Investigación Biomédica; EspañaFil: Escames, Germaine. Universidad de Granada. Facultad de Medicina. Departamento de Fisiología; EspañaFil: Acuña-Castroviejo, Darío. Universidad de Granada. Centro de Investigación Biomédica; EspañaFil: Acuña-Castroviejo, Darío. Universidad de Granada. Facultad de Medicina. Departamento de Fisiología; EspañaFil: Ortiz, Francisco. Universidad de Granada. Centro de Investigación Biomédica; EspañaFil: Fernández-Gil, Beatriz. Universidad de Granada. Centro de Investigación Biomédica; EspañaFil: Guerra Librero, Ana. Universidad de Granada. Centro de Investigación Biomédica; EspañaFil: García-López, Sergio. Universidad de Granada. Centro de Investigación Biomédica; EspañaFil: Shen, Ying. Universidad de Granada. Centro de Investigación Biomédica; EspañaFil: Florido, Javier. Universidad de Granada. Centro de Investigación Biomédica; EspañaAbstract: Melatonin is a natural substance ubiquitously distributed and present in almost all living species, from unicellular organisms to humans. Melatonin is synthesized not only in the pineal gland but also in most tissues in the body where it may have a cytoprotective function via paracrine or autocrine effects. Melatonin is effective in suppressing neoplastic growth in a variety of tumors. The mechanisms involved include antiproliferative effects via modulation of cell cycle, ability to induce apoptosis in cancer cells, anti-angiogenic and antimetastatic effects, anti-estrogenic activity, the capacity to decrease telomerase activity, immune modulation, and direct and indirect antioxidant effects. Besides these oncostatic properties, melatonin deserves to be considered in the treatment of cancer for two other reasons. First, because its hypnotic-chronobiotic properties, melatonin use that can allow the clinician to effectively address sleep disturbances, a major co-morbidity in cancer. Second, because melatonin’s anxiolytic and antidepressant effects, it has a possible application in two other major co-morbidities seen in cancer patients, i.e. depression and anxiety. This report summarizes the possible mechanisms involved in melatonin oncostasis and reviews what is known about the clinical application of melatonin as an adjuvant therapy in cancer patients.OMICS International2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/14462329-677110.4172/2329-6771.S1-006Cardinali D. P., et. al. Melatonin-induced oncostasis, mechanisms and clinical relevance [en línea]. Journal of Integrative Oncology. 2016, S1. doi:10.4172/2329-6771.S1-006. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1446Journal of Integrative Oncology, 2016, S1ISSN 2329-6771reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:17Zoai:ucacris:123456789/1446instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:17.89Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Melatonin-induced oncostasis, mechanisms and clinical relevance
title Melatonin-induced oncostasis, mechanisms and clinical relevance
spellingShingle Melatonin-induced oncostasis, mechanisms and clinical relevance
Cardinali, Daniel Pedro
BIOMEDICINA
MEDICINA
MELATONINA
CANCER
TUMORES
METASTASIS
APOPTOSIS
INMUNOLOGIA
title_short Melatonin-induced oncostasis, mechanisms and clinical relevance
title_full Melatonin-induced oncostasis, mechanisms and clinical relevance
title_fullStr Melatonin-induced oncostasis, mechanisms and clinical relevance
title_full_unstemmed Melatonin-induced oncostasis, mechanisms and clinical relevance
title_sort Melatonin-induced oncostasis, mechanisms and clinical relevance
dc.creator.none.fl_str_mv Cardinali, Daniel Pedro
Escames, Germaine
Acuña Castroviejo, D.
Ortiz, Francisco
Fernández Gil, Beatriz
Guerra Librero, Ana
García López, Sergio
Shen, Ying
Florido, Javier
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
Escames, Germaine
Acuña Castroviejo, D.
Ortiz, Francisco
Fernández Gil, Beatriz
Guerra Librero, Ana
García López, Sergio
Shen, Ying
Florido, Javier
author_role author
author2 Escames, Germaine
Acuña Castroviejo, D.
Ortiz, Francisco
Fernández Gil, Beatriz
Guerra Librero, Ana
García López, Sergio
Shen, Ying
Florido, Javier
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOMEDICINA
MEDICINA
MELATONINA
CANCER
TUMORES
METASTASIS
APOPTOSIS
INMUNOLOGIA
topic BIOMEDICINA
MEDICINA
MELATONINA
CANCER
TUMORES
METASTASIS
APOPTOSIS
INMUNOLOGIA
dc.description.none.fl_txt_mv Fil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Escames, Germaine. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Escames, Germaine. Universidad de Granada. Facultad de Medicina. Departamento de Fisiología; España
Fil: Acuña-Castroviejo, Darío. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Acuña-Castroviejo, Darío. Universidad de Granada. Facultad de Medicina. Departamento de Fisiología; España
Fil: Ortiz, Francisco. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Fernández-Gil, Beatriz. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Guerra Librero, Ana. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: García-López, Sergio. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Shen, Ying. Universidad de Granada. Centro de Investigación Biomédica; España
Fil: Florido, Javier. Universidad de Granada. Centro de Investigación Biomédica; España
Abstract: Melatonin is a natural substance ubiquitously distributed and present in almost all living species, from unicellular organisms to humans. Melatonin is synthesized not only in the pineal gland but also in most tissues in the body where it may have a cytoprotective function via paracrine or autocrine effects. Melatonin is effective in suppressing neoplastic growth in a variety of tumors. The mechanisms involved include antiproliferative effects via modulation of cell cycle, ability to induce apoptosis in cancer cells, anti-angiogenic and antimetastatic effects, anti-estrogenic activity, the capacity to decrease telomerase activity, immune modulation, and direct and indirect antioxidant effects. Besides these oncostatic properties, melatonin deserves to be considered in the treatment of cancer for two other reasons. First, because its hypnotic-chronobiotic properties, melatonin use that can allow the clinician to effectively address sleep disturbances, a major co-morbidity in cancer. Second, because melatonin’s anxiolytic and antidepressant effects, it has a possible application in two other major co-morbidities seen in cancer patients, i.e. depression and anxiety. This report summarizes the possible mechanisms involved in melatonin oncostasis and reviews what is known about the clinical application of melatonin as an adjuvant therapy in cancer patients.
description Fil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1446
2329-6771
10.4172/2329-6771.S1-006
Cardinali D. P., et. al. Melatonin-induced oncostasis, mechanisms and clinical relevance [en línea]. Journal of Integrative Oncology. 2016, S1. doi:10.4172/2329-6771.S1-006. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1446
url https://repositorio.uca.edu.ar/handle/123456789/1446
identifier_str_mv 2329-6771
10.4172/2329-6771.S1-006
Cardinali D. P., et. al. Melatonin-induced oncostasis, mechanisms and clinical relevance [en línea]. Journal of Integrative Oncology. 2016, S1. doi:10.4172/2329-6771.S1-006. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1446
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv OMICS International
publisher.none.fl_str_mv OMICS International
dc.source.none.fl_str_mv Journal of Integrative Oncology, 2016, S1
ISSN 2329-6771
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
_version_ 1836638330117160960
score 13.070432

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