Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features

Autores
Aldana, A. A.; Malatto, L.; Ur Rehman, M. A.; Boccaccini, A. R.; Abraham, G. A.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The design of biomimetic biomaterials for cell culture has become a great tool to study and understand cell behavior, tissue degradation, and lesion. Topographical and morphological features play an important role in modulating cell behavior. In this study, a dual methodology was evaluated to generate novel gelatin methacrylate (GelMA)-based scaffolds with nano and micro topographical and morphological features. First, electrospinning parameters and crosslinking processes were optimized to obtain electrospun nanofibrous scaffolds. GelMA mats were characterized by SEM, FTIR, DSC, TGA, contact angle, and water uptake. Various nanofibrous GelMA mats with defect-free fibers and stability in aqueous media were obtained. Then, micropatterned molds produced by photolithography were used as collectors in the electrospinning process. Thus, biocompatible GelMA nanofibrous scaffolds with micro-patterns that mimic extracellular matrix were obtained successfully by combining two micro/nanofabrication techniques, electrospinning, and micromolding. Taking into account the cell viability results, the methodology used in this study could be considered a valuable tool to develop patterned GelMA based nanofibrous scaffolds for cell culture and tissue engineering.
Fil: Aldana, A. A. Universidad Nacional de Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Malatto, L. Instituto Nacional de Tecnología Industrial. INTI-Micro y Nanoelectrónica; Argentina
Fil: Ur Rehman, M. A. University of Erlangen-Nuremberg. Department of Materials Science and Engineering; Alemania
Fil: Boccaccini, A. R. University of Erlangen-Nuremberg. Department of Materials Science and Engineering; Alemania
Fil: Abraham, G. A. Institute of Space Technology Islamabad; Pakistán
Fuente
Nanomaterials, 9(1)
Materia
Andamios
Metacrilatos
Gelatinas
Biomateriales
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI)
Institución
Instituto Nacional de Tecnología Industrial
OAI Identificador
nuevadc:Malatto2019GelMA_pdf
Acceder
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network_acronym_str RIINTI
repository_id_str
network_name_str Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI)
spelling Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological featuresAldana, A. A.Malatto, L.Ur Rehman, M. A.Boccaccini, A. R.Abraham, G. A.AndamiosMetacrilatosGelatinasBiomaterialesThe design of biomimetic biomaterials for cell culture has become a great tool to study and understand cell behavior, tissue degradation, and lesion. Topographical and morphological features play an important role in modulating cell behavior. In this study, a dual methodology was evaluated to generate novel gelatin methacrylate (GelMA)-based scaffolds with nano and micro topographical and morphological features. First, electrospinning parameters and crosslinking processes were optimized to obtain electrospun nanofibrous scaffolds. GelMA mats were characterized by SEM, FTIR, DSC, TGA, contact angle, and water uptake. Various nanofibrous GelMA mats with defect-free fibers and stability in aqueous media were obtained. Then, micropatterned molds produced by photolithography were used as collectors in the electrospinning process. Thus, biocompatible GelMA nanofibrous scaffolds with micro-patterns that mimic extracellular matrix were obtained successfully by combining two micro/nanofabrication techniques, electrospinning, and micromolding. Taking into account the cell viability results, the methodology used in this study could be considered a valuable tool to develop patterned GelMA based nanofibrous scaffolds for cell culture and tissue engineering.Fil: Aldana, A. A. Universidad Nacional de Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Malatto, L. Instituto Nacional de Tecnología Industrial. INTI-Micro y Nanoelectrónica; ArgentinaFil: Ur Rehman, M. A. University of Erlangen-Nuremberg. Department of Materials Science and Engineering; AlemaniaFil: Boccaccini, A. R. University of Erlangen-Nuremberg. Department of Materials Science and Engineering; AlemaniaFil: Abraham, G. A. Institute of Space Technology Islamabad; PakistánMDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfMalatto2019GelMA.pdfhttps://app.inti.gob.ar/greenstone3/sites/localsite/collect/nuevadc/index/assoc/Malatto2.dir/doc.pdfNanomaterials, 9(1)reponame:Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI)instname:Instituto Nacional de Tecnología Industrialenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/openAccess2025-09-29T15:02:06Znuevadc:Malatto2019GelMA_pdfinstacron:INTIInstitucionalhttps://app.inti.gob.ar/greenstone3/biblioOrganismo científico-tecnológicohttps://argentina.gob.ar/intihttps://app.inti.gob.ar/greenstone3/oaiserver?verb=Identifypfalcato@inti.gob.arArgentinaopendoar:2025-09-29 15:02:07.08Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI) - Instituto Nacional de Tecnología Industrialfalse
dc.title.none.fl_str_mv Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features
title Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features
spellingShingle Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features
Aldana, A. A.
Andamios
Metacrilatos
Gelatinas
Biomateriales
title_short Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features
title_full Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features
title_fullStr Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features
title_full_unstemmed Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features
title_sort Fabrication of Gelatin Methacrylate (GelMA) scaffolds with nano- and micro-topographical and morphological features
dc.creator.none.fl_str_mv Aldana, A. A.
Malatto, L.
Ur Rehman, M. A.
Boccaccini, A. R.
Abraham, G. A.
author Aldana, A. A.
author_facet Aldana, A. A.
Malatto, L.
Ur Rehman, M. A.
Boccaccini, A. R.
Abraham, G. A.
author_role author
author2 Malatto, L.
Ur Rehman, M. A.
Boccaccini, A. R.
Abraham, G. A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Andamios
Metacrilatos
Gelatinas
Biomateriales
topic Andamios
Metacrilatos
Gelatinas
Biomateriales
dc.description.none.fl_txt_mv The design of biomimetic biomaterials for cell culture has become a great tool to study and understand cell behavior, tissue degradation, and lesion. Topographical and morphological features play an important role in modulating cell behavior. In this study, a dual methodology was evaluated to generate novel gelatin methacrylate (GelMA)-based scaffolds with nano and micro topographical and morphological features. First, electrospinning parameters and crosslinking processes were optimized to obtain electrospun nanofibrous scaffolds. GelMA mats were characterized by SEM, FTIR, DSC, TGA, contact angle, and water uptake. Various nanofibrous GelMA mats with defect-free fibers and stability in aqueous media were obtained. Then, micropatterned molds produced by photolithography were used as collectors in the electrospinning process. Thus, biocompatible GelMA nanofibrous scaffolds with micro-patterns that mimic extracellular matrix were obtained successfully by combining two micro/nanofabrication techniques, electrospinning, and micromolding. Taking into account the cell viability results, the methodology used in this study could be considered a valuable tool to develop patterned GelMA based nanofibrous scaffolds for cell culture and tissue engineering.
Fil: Aldana, A. A. Universidad Nacional de Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Malatto, L. Instituto Nacional de Tecnología Industrial. INTI-Micro y Nanoelectrónica; Argentina
Fil: Ur Rehman, M. A. University of Erlangen-Nuremberg. Department of Materials Science and Engineering; Alemania
Fil: Boccaccini, A. R. University of Erlangen-Nuremberg. Department of Materials Science and Engineering; Alemania
Fil: Abraham, G. A. Institute of Space Technology Islamabad; Pakistán
description The design of biomimetic biomaterials for cell culture has become a great tool to study and understand cell behavior, tissue degradation, and lesion. Topographical and morphological features play an important role in modulating cell behavior. In this study, a dual methodology was evaluated to generate novel gelatin methacrylate (GelMA)-based scaffolds with nano and micro topographical and morphological features. First, electrospinning parameters and crosslinking processes were optimized to obtain electrospun nanofibrous scaffolds. GelMA mats were characterized by SEM, FTIR, DSC, TGA, contact angle, and water uptake. Various nanofibrous GelMA mats with defect-free fibers and stability in aqueous media were obtained. Then, micropatterned molds produced by photolithography were used as collectors in the electrospinning process. Thus, biocompatible GelMA nanofibrous scaffolds with micro-patterns that mimic extracellular matrix were obtained successfully by combining two micro/nanofabrication techniques, electrospinning, and micromolding. Taking into account the cell viability results, the methodology used in this study could be considered a valuable tool to develop patterned GelMA based nanofibrous scaffolds for cell culture and tissue engineering.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Malatto2019GelMA.pdf
https://app.inti.gob.ar/greenstone3/sites/localsite/collect/nuevadc/index/assoc/Malatto2.dir/doc.pdf
identifier_str_mv Malatto2019GelMA.pdf
url https://app.inti.gob.ar/greenstone3/sites/localsite/collect/nuevadc/index/assoc/Malatto2.dir/doc.pdf
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
openAccess
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Nanomaterials, 9(1)
reponame:Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI)
instname:Instituto Nacional de Tecnología Industrial
reponame_str Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI)
collection Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI)
instname_str Instituto Nacional de Tecnología Industrial
repository.name.fl_str_mv Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI) - Instituto Nacional de Tecnología Industrial
repository.mail.fl_str_mv pfalcato@inti.gob.ar
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score 12.559606

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