Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
- Autores
- Interlandi, Victoria; Fontanetti, Pablo Alejandro; Ponce, Rubén Hugo; Tirao, Germán Alfredo; Rigalli, Alfredo; Gallará, Raquel Vivian; Centeno, Viviana Andrea
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; Argentina
Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Controversy exists over the maternal-fetal passage of fluoride (F-). This work sought to explore different aspects of F- metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F- accumulation in bones and teeth and growth morphometric parameters in the offspring of mothers exposed to high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups of mothers were used: a) controls mothers (0.3 mg/L F-); b) treated mothers (50mg/L F-). The treatment was performed during the period of pregnancy and lactation. All animals were euthanized and the upper and lower jaw and tibia of mothers were removed for the determination of F-. Incisors diameter, mandibular growth and tibia length were determined on RX digitalized images. Results were analyzed by Student t test. Accumulated F- content was significantly higher in the jaws (p <0.05), incisor (p<0.01) and tibia (p <0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old pups born to treated mothers, F- content in jaws did not differ from the control. However, in 21-day-old pups, accumulated F- was higher (p <0.05). No differences were found in F- content or growth parameters in tibia of the offspring in all studied groups. Lower incisor diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F- compared to their controls (p<0.01). The results suggest that F- accumulation in calcified tissues of the offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur through milk during lactation. Further studies would help to elucidate the mechanism of this process.
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; Argentina
Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Patología - Materia
-
Fluoruros
Embarazo
Lactancia
Feto - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
.jpg)
- Institución
- Universidad Nacional de Córdoba
- OAI Identificador
- oai:rdu.unc.edu.ar:11086/20175
Ver los metadatos del registro completo
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Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of ratsInterlandi, VictoriaFontanetti, Pablo AlejandroPonce, Rubén HugoTirao, Germán AlfredoRigalli, AlfredoGallará, Raquel VivianCenteno, Viviana AndreaFluorurosEmbarazoLactanciaFetoFil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; ArgentinaFil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; ArgentinaFil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaControversy exists over the maternal-fetal passage of fluoride (F-). This work sought to explore different aspects of F- metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F- accumulation in bones and teeth and growth morphometric parameters in the offspring of mothers exposed to high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups of mothers were used: a) controls mothers (0.3 mg/L F-); b) treated mothers (50mg/L F-). The treatment was performed during the period of pregnancy and lactation. All animals were euthanized and the upper and lower jaw and tibia of mothers were removed for the determination of F-. Incisors diameter, mandibular growth and tibia length were determined on RX digitalized images. Results were analyzed by Student t test. Accumulated F- content was significantly higher in the jaws (p <0.05), incisor (p<0.01) and tibia (p <0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old pups born to treated mothers, F- content in jaws did not differ from the control. However, in 21-day-old pups, accumulated F- was higher (p <0.05). No differences were found in F- content or growth parameters in tibia of the offspring in all studied groups. Lower incisor diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F- compared to their controls (p<0.01). The results suggest that F- accumulation in calcified tissues of the offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur through milk during lactation. Further studies would help to elucidate the mechanism of this process.Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; ArgentinaFil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; ArgentinaFil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaPatologíaElsevier2014info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/20175enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:42:57Zoai:rdu.unc.edu.ar:11086/20175Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:42:57.896Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse |
| dc.title.none.fl_str_mv |
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title |
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| spellingShingle |
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats Interlandi, Victoria Fluoruros Embarazo Lactancia Feto |
| title_short |
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_full |
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_fullStr |
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_full_unstemmed |
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_sort |
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| dc.creator.none.fl_str_mv |
Interlandi, Victoria Fontanetti, Pablo Alejandro Ponce, Rubén Hugo Tirao, Germán Alfredo Rigalli, Alfredo Gallará, Raquel Vivian Centeno, Viviana Andrea |
| author |
Interlandi, Victoria |
| author_facet |
Interlandi, Victoria Fontanetti, Pablo Alejandro Ponce, Rubén Hugo Tirao, Germán Alfredo Rigalli, Alfredo Gallará, Raquel Vivian Centeno, Viviana Andrea |
| author_role |
author |
| author2 |
Fontanetti, Pablo Alejandro Ponce, Rubén Hugo Tirao, Germán Alfredo Rigalli, Alfredo Gallará, Raquel Vivian Centeno, Viviana Andrea |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Fluoruros Embarazo Lactancia Feto |
| topic |
Fluoruros Embarazo Lactancia Feto |
| dc.description.none.fl_txt_mv |
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; Argentina Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina Controversy exists over the maternal-fetal passage of fluoride (F-). This work sought to explore different aspects of F- metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F- accumulation in bones and teeth and growth morphometric parameters in the offspring of mothers exposed to high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups of mothers were used: a) controls mothers (0.3 mg/L F-); b) treated mothers (50mg/L F-). The treatment was performed during the period of pregnancy and lactation. All animals were euthanized and the upper and lower jaw and tibia of mothers were removed for the determination of F-. Incisors diameter, mandibular growth and tibia length were determined on RX digitalized images. Results were analyzed by Student t test. Accumulated F- content was significantly higher in the jaws (p <0.05), incisor (p<0.01) and tibia (p <0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old pups born to treated mothers, F- content in jaws did not differ from the control. However, in 21-day-old pups, accumulated F- was higher (p <0.05). No differences were found in F- content or growth parameters in tibia of the offspring in all studied groups. Lower incisor diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F- compared to their controls (p<0.01). The results suggest that F- accumulation in calcified tissues of the offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur through milk during lactation. Further studies would help to elucidate the mechanism of this process. Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; Argentina Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina Patología |
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Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina |
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2014 |
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2014 |
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