Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats

Autores
Interlandi, Victoria; Fontanetti, Pablo Alejandro; Ponce, Rubén Hugo; Tirao, Germán Alfredo; Rigalli, Alfredo; Gallará, Raquel Vivian; Centeno, Viviana Andrea
Año de publicación
2014
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; Argentina
Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Controversy exists over the maternal-fetal passage of fluoride (F-). This work sought to explore different aspects of F- metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F- accumulation in bones and teeth and growth morphometric parameters in the offspring of mothers exposed to high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups of mothers were used: a) controls mothers (0.3 mg/L F-); b) treated mothers (50mg/L F-). The treatment was performed during the period of pregnancy and lactation. All animals were euthanized and the upper and lower jaw and tibia of mothers were removed for the determination of F-. Incisors diameter, mandibular growth and tibia length were determined on RX digitalized images. Results were analyzed by Student t test. Accumulated F- content was significantly higher in the jaws (p <0.05), incisor (p<0.01) and tibia (p <0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old pups born to treated mothers, F- content in jaws did not differ from the control. However, in 21-day-old pups, accumulated F- was higher (p <0.05). No differences were found in F- content or growth parameters in tibia of the offspring in all studied groups. Lower incisor diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F- compared to their controls (p<0.01). The results suggest that F- accumulation in calcified tissues of the offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur through milk during lactation. Further studies would help to elucidate the mechanism of this process.
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; Argentina
Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Patología
Materia
Fluoruros
Embarazo
Lactancia
Feto
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/20175
Acceder
id RDUUNC_ed8d1d36027d412d940678afe007bd23
oai_identifier_str oai:rdu.unc.edu.ar:11086/20175
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of ratsInterlandi, VictoriaFontanetti, Pablo AlejandroPonce, Rubén HugoTirao, Germán AlfredoRigalli, AlfredoGallará, Raquel VivianCenteno, Viviana AndreaFluorurosEmbarazoLactanciaFetoFil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; ArgentinaFil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; ArgentinaFil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaControversy exists over the maternal-fetal passage of fluoride (F-). This work sought to explore different aspects of F- metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F- accumulation in bones and teeth and growth morphometric parameters in the offspring of mothers exposed to high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups of mothers were used: a) controls mothers (0.3 mg/L F-); b) treated mothers (50mg/L F-). The treatment was performed during the period of pregnancy and lactation. All animals were euthanized and the upper and lower jaw and tibia of mothers were removed for the determination of F-. Incisors diameter, mandibular growth and tibia length were determined on RX digitalized images. Results were analyzed by Student t test. Accumulated F- content was significantly higher in the jaws (p &lt;0.05), incisor (p&lt;0.01) and tibia (p &lt;0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old pups born to treated mothers, F- content in jaws did not differ from the control. However, in 21-day-old pups, accumulated F- was higher (p &lt;0.05). No differences were found in F- content or growth parameters in tibia of the offspring in all studied groups. Lower incisor diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F- compared to their controls (p&lt;0.01). The results suggest that F- accumulation in calcified tissues of the offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur through milk during lactation. Further studies would help to elucidate the mechanism of this process.Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; ArgentinaFil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; ArgentinaFil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaFil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; ArgentinaPatologíaElsevier2014info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/20175enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-16T09:30:15Zoai:rdu.unc.edu.ar:11086/20175Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-16 09:30:16.089Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
spellingShingle Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
Interlandi, Victoria
Fluoruros
Embarazo
Lactancia
Feto
title_short Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_full Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_fullStr Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_full_unstemmed Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_sort Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
dc.creator.none.fl_str_mv Interlandi, Victoria
Fontanetti, Pablo Alejandro
Ponce, Rubén Hugo
Tirao, Germán Alfredo
Rigalli, Alfredo
Gallará, Raquel Vivian
Centeno, Viviana Andrea
author Interlandi, Victoria
author_facet Interlandi, Victoria
Fontanetti, Pablo Alejandro
Ponce, Rubén Hugo
Tirao, Germán Alfredo
Rigalli, Alfredo
Gallará, Raquel Vivian
Centeno, Viviana Andrea
author_role author
author2 Fontanetti, Pablo Alejandro
Ponce, Rubén Hugo
Tirao, Germán Alfredo
Rigalli, Alfredo
Gallará, Raquel Vivian
Centeno, Viviana Andrea
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Fluoruros
Embarazo
Lactancia
Feto
topic Fluoruros
Embarazo
Lactancia
Feto
dc.description.none.fl_txt_mv Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; Argentina
Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Controversy exists over the maternal-fetal passage of fluoride (F-). This work sought to explore different aspects of F- metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F- accumulation in bones and teeth and growth morphometric parameters in the offspring of mothers exposed to high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups of mothers were used: a) controls mothers (0.3 mg/L F-); b) treated mothers (50mg/L F-). The treatment was performed during the period of pregnancy and lactation. All animals were euthanized and the upper and lower jaw and tibia of mothers were removed for the determination of F-. Incisors diameter, mandibular growth and tibia length were determined on RX digitalized images. Results were analyzed by Student t test. Accumulated F- content was significantly higher in the jaws (p &lt;0.05), incisor (p&lt;0.01) and tibia (p &lt;0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old pups born to treated mothers, F- content in jaws did not differ from the control. However, in 21-day-old pups, accumulated F- was higher (p &lt;0.05). No differences were found in F- content or growth parameters in tibia of the offspring in all studied groups. Lower incisor diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F- compared to their controls (p&lt;0.01). The results suggest that F- accumulation in calcified tissues of the offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur through milk during lactation. Further studies would help to elucidate the mechanism of this process.
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Metodología de la Investigación en Ciencias de la Salud; Argentina
Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
Patología
description Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
format conferenceObject
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11086/20175
url http://hdl.handle.net/11086/20175
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
_version_ 1846143378911133696
score 12.712165

Publicaciones similares