Effect of pamidronate and alendronate on peri-implant bone repair

Autores
Brunengo, Ignacio; Aramburú, Guillermo José; Renou, Sandra Judith; Virga, María Carolina
Año de publicación
2016
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Aramburú, Guillermo. José Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina.
Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.
Osseointegration can be modified by local and systemic factors. Administration of bisphosphonates has known effects on bone tissue remodeling. Objective: To study the effect of Pamidronate and Alendronate on peri-implant bone repair in rat tibia. Materials and Methods: 12 male Wistar rats of 160 g ± 20 g body weight. Under IP anesthesia with ketamine / xylazine solution 8 mg / 1.28 mg respectively for each 100 g of body weight, 2 x 1 mm Titanium cylindrical implants were placed in both tibia. They were divided in 3 groups of 4 each, a weekly dose was applied subcutaneously post surgery in the sector close to the surgical intervention, group SF control Physiological Solution 0.3ml / 100gr, PA group: Pamidronate 06mg / kg, group AL Alendronate 05mg / kg. Experimental times were 15 and 30 days post-surgery. Euthanasia was performed by intracardiac injection of potassium chloride, under general anesthesia. The tibias were resected, fixed in formaldehyde buffer. Images of each specimen were obtained by means of a radiovisiograph, were analyzed determining the extension of the radiopaque area from the surface of the implant (Pro Plus v.4.52). Longitudinal wear cuts were performed on the tibia implant included in methyl methacrylate. Peri-implant bone tissue area was determined. Results: The histological evaluation determined the presence of laminar bone tissue in the three groups evaluated at 15 and 30 days. No statistically significant differences were found in relation to the extent of the radiopaque area between groups and times (15 days SF: 0.45 ± 0.16 mm, AL: 0.76 ± 0.20 mm, PA: 0.78 ± 0.21 mm / 30 days SF: 0.76 ± 0.18 Mm, AL: 1.03 ± 0.25 mm, PA: 0.85 ± 0.20mm p> 0.05). No statistically significant differences were found in the area of peri-implanted bone tissue (15 days SF: 78435 ± 30355μm2, AL: 42067 ± 25022 μm2, PA: 40841 ± 2940μm2 / 30 days SF: 56650 ± 25047 μm2, AL: 49424 ± 8537μm2, PA: 33301 ± 11114μm2 p> 0.05).Conclusion: there was no evidence of alterations in the peri-implant bone repair before the administration of AL and PA in the model used. In future studies the percentage of bone tissue in contact with the surface of the implant will be evaluated.
Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Aramburú, Guillermo. José Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina.
Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.
Otras Ciencias de la Salud
Materia
Bifosfonatos
Resorción ósea
Reparación de dentadura
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/547572

id RDUUNC_a0ab4eaed612d20f333ae6dfdaf7025e
oai_identifier_str oai:rdu.unc.edu.ar:11086/547572
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Effect of pamidronate and alendronate on peri-implant bone repairBrunengo, IgnacioAramburú, Guillermo JoséRenou, Sandra JudithVirga, María CarolinaBifosfonatosResorción óseaReparación de dentaduraFil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.Fil: Aramburú, Guillermo. José Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina.Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.Osseointegration can be modified by local and systemic factors. Administration of bisphosphonates has known effects on bone tissue remodeling. Objective: To study the effect of Pamidronate and Alendronate on peri-implant bone repair in rat tibia. Materials and Methods: 12 male Wistar rats of 160 g ± 20 g body weight. Under IP anesthesia with ketamine / xylazine solution 8 mg / 1.28 mg respectively for each 100 g of body weight, 2 x 1 mm Titanium cylindrical implants were placed in both tibia. They were divided in 3 groups of 4 each, a weekly dose was applied subcutaneously post surgery in the sector close to the surgical intervention, group SF control Physiological Solution 0.3ml / 100gr, PA group: Pamidronate 06mg / kg, group AL Alendronate 05mg / kg. Experimental times were 15 and 30 days post-surgery. Euthanasia was performed by intracardiac injection of potassium chloride, under general anesthesia. The tibias were resected, fixed in formaldehyde buffer. Images of each specimen were obtained by means of a radiovisiograph, were analyzed determining the extension of the radiopaque area from the surface of the implant (Pro Plus v.4.52). Longitudinal wear cuts were performed on the tibia implant included in methyl methacrylate. Peri-implant bone tissue area was determined. Results: The histological evaluation determined the presence of laminar bone tissue in the three groups evaluated at 15 and 30 days. No statistically significant differences were found in relation to the extent of the radiopaque area between groups and times (15 days SF: 0.45 ± 0.16 mm, AL: 0.76 ± 0.20 mm, PA: 0.78 ± 0.21 mm / 30 days SF: 0.76 ± 0.18 Mm, AL: 1.03 ± 0.25 mm, PA: 0.85 ± 0.20mm p> 0.05). No statistically significant differences were found in the area of peri-implanted bone tissue (15 days SF: 78435 ± 30355μm2, AL: 42067 ± 25022 μm2, PA: 40841 ± 2940μm2 / 30 days SF: 56650 ± 25047 μm2, AL: 49424 ± 8537μm2, PA: 33301 ± 11114μm2 p> 0.05).Conclusion: there was no evidence of alterations in the peri-implant bone repair before the administration of AL and PA in the model used. In future studies the percentage of bone tissue in contact with the surface of the implant will be evaluated.Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.Fil: Aramburú, Guillermo. José Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina.Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.Otras Ciencias de la Salud2016info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/547572enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:42:37Zoai:rdu.unc.edu.ar:11086/547572Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:42:37.987Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Effect of pamidronate and alendronate on peri-implant bone repair
title Effect of pamidronate and alendronate on peri-implant bone repair
spellingShingle Effect of pamidronate and alendronate on peri-implant bone repair
Brunengo, Ignacio
Bifosfonatos
Resorción ósea
Reparación de dentadura
title_short Effect of pamidronate and alendronate on peri-implant bone repair
title_full Effect of pamidronate and alendronate on peri-implant bone repair
title_fullStr Effect of pamidronate and alendronate on peri-implant bone repair
title_full_unstemmed Effect of pamidronate and alendronate on peri-implant bone repair
title_sort Effect of pamidronate and alendronate on peri-implant bone repair
dc.creator.none.fl_str_mv Brunengo, Ignacio
Aramburú, Guillermo José
Renou, Sandra Judith
Virga, María Carolina
author Brunengo, Ignacio
author_facet Brunengo, Ignacio
Aramburú, Guillermo José
Renou, Sandra Judith
Virga, María Carolina
author_role author
author2 Aramburú, Guillermo José
Renou, Sandra Judith
Virga, María Carolina
author2_role author
author
author
dc.subject.none.fl_str_mv Bifosfonatos
Resorción ósea
Reparación de dentadura
topic Bifosfonatos
Resorción ósea
Reparación de dentadura
dc.description.none.fl_txt_mv Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Aramburú, Guillermo. José Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina.
Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.
Osseointegration can be modified by local and systemic factors. Administration of bisphosphonates has known effects on bone tissue remodeling. Objective: To study the effect of Pamidronate and Alendronate on peri-implant bone repair in rat tibia. Materials and Methods: 12 male Wistar rats of 160 g ± 20 g body weight. Under IP anesthesia with ketamine / xylazine solution 8 mg / 1.28 mg respectively for each 100 g of body weight, 2 x 1 mm Titanium cylindrical implants were placed in both tibia. They were divided in 3 groups of 4 each, a weekly dose was applied subcutaneously post surgery in the sector close to the surgical intervention, group SF control Physiological Solution 0.3ml / 100gr, PA group: Pamidronate 06mg / kg, group AL Alendronate 05mg / kg. Experimental times were 15 and 30 days post-surgery. Euthanasia was performed by intracardiac injection of potassium chloride, under general anesthesia. The tibias were resected, fixed in formaldehyde buffer. Images of each specimen were obtained by means of a radiovisiograph, were analyzed determining the extension of the radiopaque area from the surface of the implant (Pro Plus v.4.52). Longitudinal wear cuts were performed on the tibia implant included in methyl methacrylate. Peri-implant bone tissue area was determined. Results: The histological evaluation determined the presence of laminar bone tissue in the three groups evaluated at 15 and 30 days. No statistically significant differences were found in relation to the extent of the radiopaque area between groups and times (15 days SF: 0.45 ± 0.16 mm, AL: 0.76 ± 0.20 mm, PA: 0.78 ± 0.21 mm / 30 days SF: 0.76 ± 0.18 Mm, AL: 1.03 ± 0.25 mm, PA: 0.85 ± 0.20mm p> 0.05). No statistically significant differences were found in the area of peri-implanted bone tissue (15 days SF: 78435 ± 30355μm2, AL: 42067 ± 25022 μm2, PA: 40841 ± 2940μm2 / 30 days SF: 56650 ± 25047 μm2, AL: 49424 ± 8537μm2, PA: 33301 ± 11114μm2 p> 0.05).Conclusion: there was no evidence of alterations in the peri-implant bone repair before the administration of AL and PA in the model used. In future studies the percentage of bone tissue in contact with the surface of the implant will be evaluated.
Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Aramburú, Guillermo. José Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina.
Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.
Otras Ciencias de la Salud
description Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
publishDate 2016
dc.date.none.fl_str_mv 2016
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