Serum levels of proinflammatory cytokines in prostate cancer

Autores
López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
7 p.
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.
Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.
publishedVersion
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.
Epidemiología
Materia
PROSTATE
CANCER
CITOKINES
INFLAMATTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/555694
Acceder
id RDUUNC_8ef481d2ae0ec24e7dc883ca7cf07a14
oai_identifier_str oai:rdu.unc.edu.ar:11086/555694
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Serum levels of proinflammatory cytokines in prostate cancerNiveles plasmáticos de citoquinas proinflamatorias en cáncer de próstataLópez Fontana, Constanza MatildeDefagó, María TeresaHuilcaman, RicardoLopez, JoséMoore Carrasco, RodrigoPROSTATECANCERCITOKINESINFLAMATTION7 p.Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Huilcaman, Ricardo. Universidad de Talca; ChileFil: Lopez, José. Universidad Nacional de Cuyo; ArgentinaFil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.publishedVersionFil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Huilcaman, Ricardo. Universidad de Talca; ChileFil: Lopez, José. Universidad Nacional de Cuyo; ArgentinaFil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.Epidemiologíahttps://orcid.org/0000-0002-8878-3067https://orcid.org/0000-0003-4870-96602019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfLópez Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-150716-4114http://hdl.handle.net/11086/555694enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:43:32Zoai:rdu.unc.edu.ar:11086/555694Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:43:32.541Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Serum levels of proinflammatory cytokines in prostate cancer
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
title Serum levels of proinflammatory cytokines in prostate cancer
spellingShingle Serum levels of proinflammatory cytokines in prostate cancer
López Fontana, Constanza Matilde
PROSTATE
CANCER
CITOKINES
INFLAMATTION
title_short Serum levels of proinflammatory cytokines in prostate cancer
title_full Serum levels of proinflammatory cytokines in prostate cancer
title_fullStr Serum levels of proinflammatory cytokines in prostate cancer
title_full_unstemmed Serum levels of proinflammatory cytokines in prostate cancer
title_sort Serum levels of proinflammatory cytokines in prostate cancer
dc.creator.none.fl_str_mv López Fontana, Constanza Matilde
Defagó, María Teresa
Huilcaman, Ricardo
Lopez, José
Moore Carrasco, Rodrigo
author López Fontana, Constanza Matilde
author_facet López Fontana, Constanza Matilde
Defagó, María Teresa
Huilcaman, Ricardo
Lopez, José
Moore Carrasco, Rodrigo
author_role author
author2 Defagó, María Teresa
Huilcaman, Ricardo
Lopez, José
Moore Carrasco, Rodrigo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv https://orcid.org/0000-0002-8878-3067
https://orcid.org/0000-0003-4870-9660
dc.subject.none.fl_str_mv PROSTATE
CANCER
CITOKINES
INFLAMATTION
topic PROSTATE
CANCER
CITOKINES
INFLAMATTION
dc.description.none.fl_txt_mv 7 p.
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.
Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.
publishedVersion
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.
Epidemiología
description 7 p.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-15
0716-4114
http://hdl.handle.net/11086/555694
identifier_str_mv López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-15
0716-4114
url http://hdl.handle.net/11086/555694
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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score 13.070432

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