Serum levels of proinflammatory cytokines in prostate cancer
- Autores
- López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- 7 p.
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.
Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.
publishedVersion
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.
Epidemiología - Materia
-
PROSTATE
CANCER
CITOKINES
INFLAMATTION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Universidad Nacional de Córdoba
- OAI Identificador
- oai:rdu.unc.edu.ar:11086/555694
Ver los metadatos del registro completo
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Serum levels of proinflammatory cytokines in prostate cancerNiveles plasmáticos de citoquinas proinflamatorias en cáncer de próstataLópez Fontana, Constanza MatildeDefagó, María TeresaHuilcaman, RicardoLopez, JoséMoore Carrasco, RodrigoPROSTATECANCERCITOKINESINFLAMATTION7 p.Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Huilcaman, Ricardo. Universidad de Talca; ChileFil: Lopez, José. Universidad Nacional de Cuyo; ArgentinaFil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.publishedVersionFil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina.Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Huilcaman, Ricardo. Universidad de Talca; ChileFil: Lopez, José. Universidad Nacional de Cuyo; ArgentinaFil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile.Epidemiologíahttps://orcid.org/0000-0002-8878-3067https://orcid.org/0000-0003-4870-96602019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfLópez Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-150716-4114http://hdl.handle.net/11086/555694enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-04T12:33:48Zoai:rdu.unc.edu.ar:11086/555694Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-04 12:33:48.774Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse |
dc.title.none.fl_str_mv |
Serum levels of proinflammatory cytokines in prostate cancer Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata |
title |
Serum levels of proinflammatory cytokines in prostate cancer |
spellingShingle |
Serum levels of proinflammatory cytokines in prostate cancer López Fontana, Constanza Matilde PROSTATE CANCER CITOKINES INFLAMATTION |
title_short |
Serum levels of proinflammatory cytokines in prostate cancer |
title_full |
Serum levels of proinflammatory cytokines in prostate cancer |
title_fullStr |
Serum levels of proinflammatory cytokines in prostate cancer |
title_full_unstemmed |
Serum levels of proinflammatory cytokines in prostate cancer |
title_sort |
Serum levels of proinflammatory cytokines in prostate cancer |
dc.creator.none.fl_str_mv |
López Fontana, Constanza Matilde Defagó, María Teresa Huilcaman, Ricardo Lopez, José Moore Carrasco, Rodrigo |
author |
López Fontana, Constanza Matilde |
author_facet |
López Fontana, Constanza Matilde Defagó, María Teresa Huilcaman, Ricardo Lopez, José Moore Carrasco, Rodrigo |
author_role |
author |
author2 |
Defagó, María Teresa Huilcaman, Ricardo Lopez, José Moore Carrasco, Rodrigo |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
https://orcid.org/0000-0002-8878-3067 https://orcid.org/0000-0003-4870-9660 |
dc.subject.none.fl_str_mv |
PROSTATE CANCER CITOKINES INFLAMATTION |
topic |
PROSTATE CANCER CITOKINES INFLAMATTION |
dc.description.none.fl_txt_mv |
7 p. Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Huilcaman, Ricardo. Universidad de Talca; Chile Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina Fil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile. Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines. publishedVersion Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Huilcaman, Ricardo. Universidad de Talca; Chile Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina Fil: Moore Carrasco, Rodrigo. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile. Epidemiología |
description |
7 p. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-15 0716-4114 http://hdl.handle.net/11086/555694 |
identifier_str_mv |
López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-15 0716-4114 |
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http://hdl.handle.net/11086/555694 |
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eng |
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eng |
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openAccess |
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Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba |
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