Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
- Autores
- López Fontana, Gastón; Guglielmi, Juan Manuel; López Fontana, José Rodrigo; Hinojosa Jury, Mariana Lis; López Fontana, Constanza Matilde; López Laur, José Daniel
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective: To analyze the perioperatory and short-oncological outcomes in 5 cases with CRPC M0 developed after pRT that underwent salvage laparoscopic RP (sLRP) and review the current evidence. Material and Methods: Perioperatory and oncological outcomes were prospectively analyzed. Inclusion criteria were patients that had received pRT and posteriorly presented with CRPC M0 in standard imagines and positron emission tomography MRI coline. Evidence was reviewed in PUBMED database. Results: No surgical complications and blood transfusion were reported. Two patients required an endoscopic urethrotomy due to bladder neck contracture (Clavien IIIb). Final pathological findings were T3 or more, multifocal with 3 positive surgical margins. Four patients reach undetectable PSA after surgery except one that continuous under ADT without disease progression. After 12 months follow-up, 4 patients persist with undetectable PSA and one with stable disease under ADT. Current evidence demonstrated that CRPC M0 treated with open, laparoscopic or robotic RP a biochemical recurrence of 68.7% as a hormonesensitive PC; however, 17.4% were disease-free after 4 years of follow-up. Conclusion: Our serie, 4 cases are disease free after 12 months follow-up. Current evidence is a retrospective and multicenter experience with few cases and intermediate oncological follow-up. More cases with longer follow-up and better evidence are required to opt for this treatment as a first line.
Objetivo: Analizar los resultados perioperatorios y oncológicos cortos en 5 casos con CRPC M0 desarrollado después de pRT que se sometieron a PR laparoscópica de rescate (sLRP) y revisar la evidencia actual. Material y Métodos: Se analizaron prospectivamente los resultados perioperatorios y oncológicos. Los criterios de inclusión fueron pacientes que habían recibido pRT y posteriormente presentaron CRPC M0 en imagines estándar y tomografía por emisión de positrones MRI coline. Se revisó la evidencia en la base de datos PUBMED.
Fil: López Fontana, Gastón. Clínica Andina de Urología; Argentina
Fil: Guglielmi, Juan Manuel. Clínica Andina de Urología; Argentina
Fil: López Fontana, José Rodrigo. Clínica Andina de Urología; Argentina
Fil: Hinojosa Jury, Mariana Lis. Hospital Italiano; Argentina
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: López Laur, José Daniel. Clínica Andina de Urología; Argentina - Materia
-
CASTRATION-RESISTANT PROSTATE CANCER
PROSTATE CANCER
RADIOTHERAPY
SALVAGE RADICAL PROSTATECTOMY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/203199
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/203199 |
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3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancerProstatectomía radical de rescate en el cáncer de próstata no metastásico resistente a la castraciónLópez Fontana, GastónGuglielmi, Juan ManuelLópez Fontana, José RodrigoHinojosa Jury, Mariana LisLópez Fontana, Constanza MatildeLópez Laur, José DanielCASTRATION-RESISTANT PROSTATE CANCERPROSTATE CANCERRADIOTHERAPYSALVAGE RADICAL PROSTATECTOMYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: To analyze the perioperatory and short-oncological outcomes in 5 cases with CRPC M0 developed after pRT that underwent salvage laparoscopic RP (sLRP) and review the current evidence. Material and Methods: Perioperatory and oncological outcomes were prospectively analyzed. Inclusion criteria were patients that had received pRT and posteriorly presented with CRPC M0 in standard imagines and positron emission tomography MRI coline. Evidence was reviewed in PUBMED database. Results: No surgical complications and blood transfusion were reported. Two patients required an endoscopic urethrotomy due to bladder neck contracture (Clavien IIIb). Final pathological findings were T3 or more, multifocal with 3 positive surgical margins. Four patients reach undetectable PSA after surgery except one that continuous under ADT without disease progression. After 12 months follow-up, 4 patients persist with undetectable PSA and one with stable disease under ADT. Current evidence demonstrated that CRPC M0 treated with open, laparoscopic or robotic RP a biochemical recurrence of 68.7% as a hormonesensitive PC; however, 17.4% were disease-free after 4 years of follow-up. Conclusion: Our serie, 4 cases are disease free after 12 months follow-up. Current evidence is a retrospective and multicenter experience with few cases and intermediate oncological follow-up. More cases with longer follow-up and better evidence are required to opt for this treatment as a first line.Objetivo: Analizar los resultados perioperatorios y oncológicos cortos en 5 casos con CRPC M0 desarrollado después de pRT que se sometieron a PR laparoscópica de rescate (sLRP) y revisar la evidencia actual. Material y Métodos: Se analizaron prospectivamente los resultados perioperatorios y oncológicos. Los criterios de inclusión fueron pacientes que habían recibido pRT y posteriormente presentaron CRPC M0 en imagines estándar y tomografía por emisión de positrones MRI coline. Se revisó la evidencia en la base de datos PUBMED.Fil: López Fontana, Gastón. Clínica Andina de Urología; ArgentinaFil: Guglielmi, Juan Manuel. Clínica Andina de Urología; ArgentinaFil: López Fontana, José Rodrigo. Clínica Andina de Urología; ArgentinaFil: Hinojosa Jury, Mariana Lis. Hospital Italiano; ArgentinaFil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: López Laur, José Daniel. Clínica Andina de Urología; ArgentinaIniestares S. A.2022-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/203199López Fontana, Gastón; Guglielmi, Juan Manuel; López Fontana, José Rodrigo; Hinojosa Jury, Mariana Lis; López Fontana, Constanza Matilde; et al.; Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer; Iniestares S. A.; Archivos Espanoles de Urologia.; 75; 7; 9-2022; 638-6410004-0614CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.aeurologia.com/EN/10.56434/j.arch.esp.urol.20227507.92info:eu-repo/semantics/altIdentifier/doi/10.56434/j.arch.esp.urol.20227507.92info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:55Zoai:ri.conicet.gov.ar:11336/203199instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:56.257CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer Prostatectomía radical de rescate en el cáncer de próstata no metastásico resistente a la castración |
title |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer |
spellingShingle |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer López Fontana, Gastón CASTRATION-RESISTANT PROSTATE CANCER PROSTATE CANCER RADIOTHERAPY SALVAGE RADICAL PROSTATECTOMY |
title_short |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer |
title_full |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer |
title_fullStr |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer |
title_full_unstemmed |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer |
title_sort |
Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer |
dc.creator.none.fl_str_mv |
López Fontana, Gastón Guglielmi, Juan Manuel López Fontana, José Rodrigo Hinojosa Jury, Mariana Lis López Fontana, Constanza Matilde López Laur, José Daniel |
author |
López Fontana, Gastón |
author_facet |
López Fontana, Gastón Guglielmi, Juan Manuel López Fontana, José Rodrigo Hinojosa Jury, Mariana Lis López Fontana, Constanza Matilde López Laur, José Daniel |
author_role |
author |
author2 |
Guglielmi, Juan Manuel López Fontana, José Rodrigo Hinojosa Jury, Mariana Lis López Fontana, Constanza Matilde López Laur, José Daniel |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
CASTRATION-RESISTANT PROSTATE CANCER PROSTATE CANCER RADIOTHERAPY SALVAGE RADICAL PROSTATECTOMY |
topic |
CASTRATION-RESISTANT PROSTATE CANCER PROSTATE CANCER RADIOTHERAPY SALVAGE RADICAL PROSTATECTOMY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objective: To analyze the perioperatory and short-oncological outcomes in 5 cases with CRPC M0 developed after pRT that underwent salvage laparoscopic RP (sLRP) and review the current evidence. Material and Methods: Perioperatory and oncological outcomes were prospectively analyzed. Inclusion criteria were patients that had received pRT and posteriorly presented with CRPC M0 in standard imagines and positron emission tomography MRI coline. Evidence was reviewed in PUBMED database. Results: No surgical complications and blood transfusion were reported. Two patients required an endoscopic urethrotomy due to bladder neck contracture (Clavien IIIb). Final pathological findings were T3 or more, multifocal with 3 positive surgical margins. Four patients reach undetectable PSA after surgery except one that continuous under ADT without disease progression. After 12 months follow-up, 4 patients persist with undetectable PSA and one with stable disease under ADT. Current evidence demonstrated that CRPC M0 treated with open, laparoscopic or robotic RP a biochemical recurrence of 68.7% as a hormonesensitive PC; however, 17.4% were disease-free after 4 years of follow-up. Conclusion: Our serie, 4 cases are disease free after 12 months follow-up. Current evidence is a retrospective and multicenter experience with few cases and intermediate oncological follow-up. More cases with longer follow-up and better evidence are required to opt for this treatment as a first line. Objetivo: Analizar los resultados perioperatorios y oncológicos cortos en 5 casos con CRPC M0 desarrollado después de pRT que se sometieron a PR laparoscópica de rescate (sLRP) y revisar la evidencia actual. Material y Métodos: Se analizaron prospectivamente los resultados perioperatorios y oncológicos. Los criterios de inclusión fueron pacientes que habían recibido pRT y posteriormente presentaron CRPC M0 en imagines estándar y tomografía por emisión de positrones MRI coline. Se revisó la evidencia en la base de datos PUBMED. Fil: López Fontana, Gastón. Clínica Andina de Urología; Argentina Fil: Guglielmi, Juan Manuel. Clínica Andina de Urología; Argentina Fil: López Fontana, José Rodrigo. Clínica Andina de Urología; Argentina Fil: Hinojosa Jury, Mariana Lis. Hospital Italiano; Argentina Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: López Laur, José Daniel. Clínica Andina de Urología; Argentina |
description |
Objective: To analyze the perioperatory and short-oncological outcomes in 5 cases with CRPC M0 developed after pRT that underwent salvage laparoscopic RP (sLRP) and review the current evidence. Material and Methods: Perioperatory and oncological outcomes were prospectively analyzed. Inclusion criteria were patients that had received pRT and posteriorly presented with CRPC M0 in standard imagines and positron emission tomography MRI coline. Evidence was reviewed in PUBMED database. Results: No surgical complications and blood transfusion were reported. Two patients required an endoscopic urethrotomy due to bladder neck contracture (Clavien IIIb). Final pathological findings were T3 or more, multifocal with 3 positive surgical margins. Four patients reach undetectable PSA after surgery except one that continuous under ADT without disease progression. After 12 months follow-up, 4 patients persist with undetectable PSA and one with stable disease under ADT. Current evidence demonstrated that CRPC M0 treated with open, laparoscopic or robotic RP a biochemical recurrence of 68.7% as a hormonesensitive PC; however, 17.4% were disease-free after 4 years of follow-up. Conclusion: Our serie, 4 cases are disease free after 12 months follow-up. Current evidence is a retrospective and multicenter experience with few cases and intermediate oncological follow-up. More cases with longer follow-up and better evidence are required to opt for this treatment as a first line. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/203199 López Fontana, Gastón; Guglielmi, Juan Manuel; López Fontana, José Rodrigo; Hinojosa Jury, Mariana Lis; López Fontana, Constanza Matilde; et al.; Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer; Iniestares S. A.; Archivos Espanoles de Urologia.; 75; 7; 9-2022; 638-641 0004-0614 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/203199 |
identifier_str_mv |
López Fontana, Gastón; Guglielmi, Juan Manuel; López Fontana, José Rodrigo; Hinojosa Jury, Mariana Lis; López Fontana, Constanza Matilde; et al.; Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer; Iniestares S. A.; Archivos Espanoles de Urologia.; 75; 7; 9-2022; 638-641 0004-0614 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.aeurologia.com/EN/10.56434/j.arch.esp.urol.20227507.92 info:eu-repo/semantics/altIdentifier/doi/10.56434/j.arch.esp.urol.20227507.92 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Iniestares S. A. |
publisher.none.fl_str_mv |
Iniestares S. A. |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269934986461184 |
score |
13.13397 |