Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer

Autores
López Fontana, Gastón; Guglielmi, Juan Manuel; López Fontana, José Rodrigo; Hinojosa Jury, Mariana Lis; López Fontana, Constanza Matilde; López Laur, José Daniel
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To analyze the perioperatory and short-oncological outcomes in 5 cases with CRPC M0 developed after pRT that underwent salvage laparoscopic RP (sLRP) and review the current evidence. Material and Methods: Perioperatory and oncological outcomes were prospectively analyzed. Inclusion criteria were patients that had received pRT and posteriorly presented with CRPC M0 in standard imagines and positron emission tomography MRI coline. Evidence was reviewed in PUBMED database. Results: No surgical complications and blood transfusion were reported. Two patients required an endoscopic urethrotomy due to bladder neck contracture (Clavien IIIb). Final pathological findings were T3 or more, multifocal with 3 positive surgical margins. Four patients reach undetectable PSA after surgery except one that continuous under ADT without disease progression. After 12 months follow-up, 4 patients persist with undetectable PSA and one with stable disease under ADT. Current evidence demonstrated that CRPC M0 treated with open, laparoscopic or robotic RP a biochemical recurrence of 68.7% as a hormonesensitive PC; however, 17.4% were disease-free after 4 years of follow-up. Conclusion: Our serie, 4 cases are disease free after 12 months follow-up. Current evidence is a retrospective and multicenter experience with few cases and intermediate oncological follow-up. More cases with longer follow-up and better evidence are required to opt for this treatment as a first line.
Objetivo: Analizar los resultados perioperatorios y oncológicos cortos en 5 casos con CRPC M0 desarrollado después de pRT que se sometieron a PR laparoscópica de rescate (sLRP) y revisar la evidencia actual. Material y Métodos: Se analizaron prospectivamente los resultados perioperatorios y oncológicos. Los criterios de inclusión fueron pacientes que habían recibido pRT y posteriormente presentaron CRPC M0 en imagines estándar y tomografía por emisión de positrones MRI coline. Se revisó la evidencia en la base de datos PUBMED.
Fil: López Fontana, Gastón. Clínica Andina de Urología; Argentina
Fil: Guglielmi, Juan Manuel. Clínica Andina de Urología; Argentina
Fil: López Fontana, José Rodrigo. Clínica Andina de Urología; Argentina
Fil: Hinojosa Jury, Mariana Lis. Hospital Italiano; Argentina
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: López Laur, José Daniel. Clínica Andina de Urología; Argentina
Materia
CASTRATION-RESISTANT PROSTATE CANCER
PROSTATE CANCER
RADIOTHERAPY
SALVAGE RADICAL PROSTATECTOMY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/203199
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/203199
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancerProstatectomía radical de rescate en el cáncer de próstata no metastásico resistente a la castraciónLópez Fontana, GastónGuglielmi, Juan ManuelLópez Fontana, José RodrigoHinojosa Jury, Mariana LisLópez Fontana, Constanza MatildeLópez Laur, José DanielCASTRATION-RESISTANT PROSTATE CANCERPROSTATE CANCERRADIOTHERAPYSALVAGE RADICAL PROSTATECTOMYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: To analyze the perioperatory and short-oncological outcomes in 5 cases with CRPC M0 developed after pRT that underwent salvage laparoscopic RP (sLRP) and review the current evidence. Material and Methods: Perioperatory and oncological outcomes were prospectively analyzed. Inclusion criteria were patients that had received pRT and posteriorly presented with CRPC M0 in standard imagines and positron emission tomography MRI coline. Evidence was reviewed in PUBMED database. Results: No surgical complications and blood transfusion were reported. Two patients required an endoscopic urethrotomy due to bladder neck contracture (Clavien IIIb). Final pathological findings were T3 or more, multifocal with 3 positive surgical margins. Four patients reach undetectable PSA after surgery except one that continuous under ADT without disease progression. After 12 months follow-up, 4 patients persist with undetectable PSA and one with stable disease under ADT. Current evidence demonstrated that CRPC M0 treated with open, laparoscopic or robotic RP a biochemical recurrence of 68.7% as a hormonesensitive PC; however, 17.4% were disease-free after 4 years of follow-up. Conclusion: Our serie, 4 cases are disease free after 12 months follow-up. Current evidence is a retrospective and multicenter experience with few cases and intermediate oncological follow-up. More cases with longer follow-up and better evidence are required to opt for this treatment as a first line.Objetivo: Analizar los resultados perioperatorios y oncológicos cortos en 5 casos con CRPC M0 desarrollado después de pRT que se sometieron a PR laparoscópica de rescate (sLRP) y revisar la evidencia actual. Material y Métodos: Se analizaron prospectivamente los resultados perioperatorios y oncológicos. Los criterios de inclusión fueron pacientes que habían recibido pRT y posteriormente presentaron CRPC M0 en imagines estándar y tomografía por emisión de positrones MRI coline. Se revisó la evidencia en la base de datos PUBMED.Fil: López Fontana, Gastón. Clínica Andina de Urología; ArgentinaFil: Guglielmi, Juan Manuel. Clínica Andina de Urología; ArgentinaFil: López Fontana, José Rodrigo. Clínica Andina de Urología; ArgentinaFil: Hinojosa Jury, Mariana Lis. Hospital Italiano; ArgentinaFil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: López Laur, José Daniel. Clínica Andina de Urología; ArgentinaIniestares S. A.2022-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/203199López Fontana, Gastón; Guglielmi, Juan Manuel; López Fontana, José Rodrigo; Hinojosa Jury, Mariana Lis; López Fontana, Constanza Matilde; et al.; Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer; Iniestares S. A.; Archivos Espanoles de Urologia.; 75; 7; 9-2022; 638-6410004-0614CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.aeurologia.com/EN/10.56434/j.arch.esp.urol.20227507.92info:eu-repo/semantics/altIdentifier/doi/10.56434/j.arch.esp.urol.20227507.92info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:28:23Zoai:ri.conicet.gov.ar:11336/203199instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:28:23.745CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
Prostatectomía radical de rescate en el cáncer de próstata no metastásico resistente a la castración
title Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
spellingShingle Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
López Fontana, Gastón
CASTRATION-RESISTANT PROSTATE CANCER
PROSTATE CANCER
RADIOTHERAPY
SALVAGE RADICAL PROSTATECTOMY
title_short Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
title_full Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
title_fullStr Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
title_full_unstemmed Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
title_sort Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer
dc.creator.none.fl_str_mv López Fontana, Gastón
Guglielmi, Juan Manuel
López Fontana, José Rodrigo
Hinojosa Jury, Mariana Lis
López Fontana, Constanza Matilde
López Laur, José Daniel
author López Fontana, Gastón
author_facet López Fontana, Gastón
Guglielmi, Juan Manuel
López Fontana, José Rodrigo
Hinojosa Jury, Mariana Lis
López Fontana, Constanza Matilde
López Laur, José Daniel
author_role author
author2 Guglielmi, Juan Manuel
López Fontana, José Rodrigo
Hinojosa Jury, Mariana Lis
López Fontana, Constanza Matilde
López Laur, José Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CASTRATION-RESISTANT PROSTATE CANCER
PROSTATE CANCER
RADIOTHERAPY
SALVAGE RADICAL PROSTATECTOMY
topic CASTRATION-RESISTANT PROSTATE CANCER
PROSTATE CANCER
RADIOTHERAPY
SALVAGE RADICAL PROSTATECTOMY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To analyze the perioperatory and short-oncological outcomes in 5 cases with CRPC M0 developed after pRT that underwent salvage laparoscopic RP (sLRP) and review the current evidence. Material and Methods: Perioperatory and oncological outcomes were prospectively analyzed. Inclusion criteria were patients that had received pRT and posteriorly presented with CRPC M0 in standard imagines and positron emission tomography MRI coline. Evidence was reviewed in PUBMED database. Results: No surgical complications and blood transfusion were reported. Two patients required an endoscopic urethrotomy due to bladder neck contracture (Clavien IIIb). Final pathological findings were T3 or more, multifocal with 3 positive surgical margins. Four patients reach undetectable PSA after surgery except one that continuous under ADT without disease progression. After 12 months follow-up, 4 patients persist with undetectable PSA and one with stable disease under ADT. Current evidence demonstrated that CRPC M0 treated with open, laparoscopic or robotic RP a biochemical recurrence of 68.7% as a hormonesensitive PC; however, 17.4% were disease-free after 4 years of follow-up. Conclusion: Our serie, 4 cases are disease free after 12 months follow-up. Current evidence is a retrospective and multicenter experience with few cases and intermediate oncological follow-up. More cases with longer follow-up and better evidence are required to opt for this treatment as a first line.
Objetivo: Analizar los resultados perioperatorios y oncológicos cortos en 5 casos con CRPC M0 desarrollado después de pRT que se sometieron a PR laparoscópica de rescate (sLRP) y revisar la evidencia actual. Material y Métodos: Se analizaron prospectivamente los resultados perioperatorios y oncológicos. Los criterios de inclusión fueron pacientes que habían recibido pRT y posteriormente presentaron CRPC M0 en imagines estándar y tomografía por emisión de positrones MRI coline. Se revisó la evidencia en la base de datos PUBMED.
Fil: López Fontana, Gastón. Clínica Andina de Urología; Argentina
Fil: Guglielmi, Juan Manuel. Clínica Andina de Urología; Argentina
Fil: López Fontana, José Rodrigo. Clínica Andina de Urología; Argentina
Fil: Hinojosa Jury, Mariana Lis. Hospital Italiano; Argentina
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: López Laur, José Daniel. Clínica Andina de Urología; Argentina
description Objective: To analyze the perioperatory and short-oncological outcomes in 5 cases with CRPC M0 developed after pRT that underwent salvage laparoscopic RP (sLRP) and review the current evidence. Material and Methods: Perioperatory and oncological outcomes were prospectively analyzed. Inclusion criteria were patients that had received pRT and posteriorly presented with CRPC M0 in standard imagines and positron emission tomography MRI coline. Evidence was reviewed in PUBMED database. Results: No surgical complications and blood transfusion were reported. Two patients required an endoscopic urethrotomy due to bladder neck contracture (Clavien IIIb). Final pathological findings were T3 or more, multifocal with 3 positive surgical margins. Four patients reach undetectable PSA after surgery except one that continuous under ADT without disease progression. After 12 months follow-up, 4 patients persist with undetectable PSA and one with stable disease under ADT. Current evidence demonstrated that CRPC M0 treated with open, laparoscopic or robotic RP a biochemical recurrence of 68.7% as a hormonesensitive PC; however, 17.4% were disease-free after 4 years of follow-up. Conclusion: Our serie, 4 cases are disease free after 12 months follow-up. Current evidence is a retrospective and multicenter experience with few cases and intermediate oncological follow-up. More cases with longer follow-up and better evidence are required to opt for this treatment as a first line.
publishDate 2022
dc.date.none.fl_str_mv 2022-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/203199
López Fontana, Gastón; Guglielmi, Juan Manuel; López Fontana, José Rodrigo; Hinojosa Jury, Mariana Lis; López Fontana, Constanza Matilde; et al.; Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer; Iniestares S. A.; Archivos Espanoles de Urologia.; 75; 7; 9-2022; 638-641
0004-0614
CONICET Digital
CONICET
url http://hdl.handle.net/11336/203199
identifier_str_mv López Fontana, Gastón; Guglielmi, Juan Manuel; López Fontana, José Rodrigo; Hinojosa Jury, Mariana Lis; López Fontana, Constanza Matilde; et al.; Salvage radical prostatectomy in nonmetastatic castration resistant prostate cancer; Iniestares S. A.; Archivos Espanoles de Urologia.; 75; 7; 9-2022; 638-641
0004-0614
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.aeurologia.com/EN/10.56434/j.arch.esp.urol.20227507.92
info:eu-repo/semantics/altIdentifier/doi/10.56434/j.arch.esp.urol.20227507.92
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Iniestares S. A.
publisher.none.fl_str_mv Iniestares S. A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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