Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
- Autores
- López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca; Chile. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile - Materia
-
PROSTATE
CANCER
CITOKINES
UNFLAMMATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/211789
Ver los metadatos del registro completo
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Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstataSerum levels of proinflammatory cytokines in prostate cancerLópez Fontana, Constanza MatildeDefagó, María TeresaHuilcaman, RicardoLopez, JoséMoore Carrasco, RodrigoPROSTATECANCERCITOKINESUNFLAMMATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Huilcaman, Ricardo. Universidad de Talca; ChileFil: Lopez, José. Universidad Nacional de Cuyo; ArgentinaFil: Moore Carrasco, Rodrigo. Universidad de Talca; Chile. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; ChileSociedad Medica del Centro2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211789López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-150716-4114CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.revmedmaule.cl/volumen-34-n-1-ago-2019/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:17Zoai:ri.conicet.gov.ar:11336/211789instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:17.916CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata Serum levels of proinflammatory cytokines in prostate cancer |
title |
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata |
spellingShingle |
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata López Fontana, Constanza Matilde PROSTATE CANCER CITOKINES UNFLAMMATION |
title_short |
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata |
title_full |
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata |
title_fullStr |
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata |
title_full_unstemmed |
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata |
title_sort |
Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata |
dc.creator.none.fl_str_mv |
López Fontana, Constanza Matilde Defagó, María Teresa Huilcaman, Ricardo Lopez, José Moore Carrasco, Rodrigo |
author |
López Fontana, Constanza Matilde |
author_facet |
López Fontana, Constanza Matilde Defagó, María Teresa Huilcaman, Ricardo Lopez, José Moore Carrasco, Rodrigo |
author_role |
author |
author2 |
Defagó, María Teresa Huilcaman, Ricardo Lopez, José Moore Carrasco, Rodrigo |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
PROSTATE CANCER CITOKINES UNFLAMMATION |
topic |
PROSTATE CANCER CITOKINES UNFLAMMATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines. Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Huilcaman, Ricardo. Universidad de Talca; Chile Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina Fil: Moore Carrasco, Rodrigo. Universidad de Talca; Chile. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile |
description |
Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/211789 López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-15 0716-4114 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/211789 |
identifier_str_mv |
López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-15 0716-4114 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.revmedmaule.cl/volumen-34-n-1-ago-2019/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sociedad Medica del Centro |
publisher.none.fl_str_mv |
Sociedad Medica del Centro |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268784807641088 |
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13.13397 |