Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata

Autores
López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca; Chile. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile
Materia
PROSTATE
CANCER
CITOKINES
UNFLAMMATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211789
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/211789
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstataSerum levels of proinflammatory cytokines in prostate cancerLópez Fontana, Constanza MatildeDefagó, María TeresaHuilcaman, RicardoLopez, JoséMoore Carrasco, RodrigoPROSTATECANCERCITOKINESUNFLAMMATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Huilcaman, Ricardo. Universidad de Talca; ChileFil: Lopez, José. Universidad Nacional de Cuyo; ArgentinaFil: Moore Carrasco, Rodrigo. Universidad de Talca; Chile. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; ChileSociedad Medica del Centro2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211789López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-150716-4114CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.revmedmaule.cl/volumen-34-n-1-ago-2019/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:21Zoai:ri.conicet.gov.ar:11336/211789instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:21.555CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
Serum levels of proinflammatory cytokines in prostate cancer
title Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
spellingShingle Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
López Fontana, Constanza Matilde
PROSTATE
CANCER
CITOKINES
UNFLAMMATION
title_short Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
title_full Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
title_fullStr Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
title_full_unstemmed Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
title_sort Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata
dc.creator.none.fl_str_mv López Fontana, Constanza Matilde
Defagó, María Teresa
Huilcaman, Ricardo
Lopez, José
Moore Carrasco, Rodrigo
author López Fontana, Constanza Matilde
author_facet López Fontana, Constanza Matilde
Defagó, María Teresa
Huilcaman, Ricardo
Lopez, José
Moore Carrasco, Rodrigo
author_role author
author2 Defagó, María Teresa
Huilcaman, Ricardo
Lopez, José
Moore Carrasco, Rodrigo
author2_role author
author
author
author
dc.subject.none.fl_str_mv PROSTATE
CANCER
CITOKINES
UNFLAMMATION
topic PROSTATE
CANCER
CITOKINES
UNFLAMMATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Huilcaman, Ricardo. Universidad de Talca; Chile
Fil: Lopez, José. Universidad Nacional de Cuyo; Argentina
Fil: Moore Carrasco, Rodrigo. Universidad de Talca; Chile. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chile
description Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211789
López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-15
0716-4114
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211789
identifier_str_mv López Fontana, Constanza Matilde; Defagó, María Teresa; Huilcaman, Ricardo; Lopez, José; Moore Carrasco, Rodrigo; Niveles plasmáticos de citoquinas proinflamatorias en cáncer de próstata; Sociedad Medica del Centro; Revista Médica del Maule; 34; 8-2019; 9-15
0716-4114
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.revmedmaule.cl/volumen-34-n-1-ago-2019/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Medica del Centro
publisher.none.fl_str_mv Sociedad Medica del Centro
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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