Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients

Autores
Zarate, Ana Maria; Don, Julieta; Secchi, Dante Gustavo; Carrica, Victoriano Andrés; Galíndez Costa, María Fernanda; Panico, René Luis; Brusa, Martin Eduardo; Barra, Jose Luis; Brunotto, Mabel Noemí
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in argentine patients.
Fil: Zarate, Ana Maria. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Don, Julieta. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Secchi, Dante Gustavo. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Carrica, Victoriano Andrés. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Galíndez Costa, María Fernanda. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Panico, René Luis. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Brusa, Martin Eduardo. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Barra, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Brunotto, Mabel Noemí. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Materia
ARGENTINE
ORAL CANCER
ORAL POTENTIALLY MALIGNANT DISORDERS
P53 CODON 72 POLYMORPHISM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/57507
Acceder
id CONICETDig_27591dfd1d2bfd36bade93458d4824df
oai_identifier_str oai:ri.conicet.gov.ar:11336/57507
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patientsZarate, Ana MariaDon, JulietaSecchi, Dante GustavoCarrica, Victoriano AndrésGalíndez Costa, María FernandaPanico, René LuisBrusa, Martin EduardoBarra, Jose LuisBrunotto, Mabel NoemíARGENTINEORAL CANCERORAL POTENTIALLY MALIGNANT DISORDERSP53 CODON 72 POLYMORPHISMhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in argentine patients.Fil: Zarate, Ana Maria. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaFil: Don, Julieta. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaFil: Secchi, Dante Gustavo. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaFil: Carrica, Victoriano Andrés. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaFil: Galíndez Costa, María Fernanda. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaFil: Panico, René Luis. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaFil: Brusa, Martin Eduardo. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaFil: Barra, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Brunotto, Mabel Noemí. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaKarger2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57507Zarate, Ana Maria; Don, Julieta; Secchi, Dante Gustavo; Carrica, Victoriano Andrés; Galíndez Costa, María Fernanda; et al.; Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients; Karger; Tumor Biology; 39; 5; 5-20171010-42831423-0380CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1010428317699113info:eu-repo/semantics/altIdentifier/doi/10.1177/1010428317699113info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:04Zoai:ri.conicet.gov.ar:11336/57507instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:04.932CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
title Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
spellingShingle Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
Zarate, Ana Maria
ARGENTINE
ORAL CANCER
ORAL POTENTIALLY MALIGNANT DISORDERS
P53 CODON 72 POLYMORPHISM
title_short Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
title_full Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
title_fullStr Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
title_full_unstemmed Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
title_sort Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
dc.creator.none.fl_str_mv Zarate, Ana Maria
Don, Julieta
Secchi, Dante Gustavo
Carrica, Victoriano Andrés
Galíndez Costa, María Fernanda
Panico, René Luis
Brusa, Martin Eduardo
Barra, Jose Luis
Brunotto, Mabel Noemí
author Zarate, Ana Maria
author_facet Zarate, Ana Maria
Don, Julieta
Secchi, Dante Gustavo
Carrica, Victoriano Andrés
Galíndez Costa, María Fernanda
Panico, René Luis
Brusa, Martin Eduardo
Barra, Jose Luis
Brunotto, Mabel Noemí
author_role author
author2 Don, Julieta
Secchi, Dante Gustavo
Carrica, Victoriano Andrés
Galíndez Costa, María Fernanda
Panico, René Luis
Brusa, Martin Eduardo
Barra, Jose Luis
Brunotto, Mabel Noemí
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARGENTINE
ORAL CANCER
ORAL POTENTIALLY MALIGNANT DISORDERS
P53 CODON 72 POLYMORPHISM
topic ARGENTINE
ORAL CANCER
ORAL POTENTIALLY MALIGNANT DISORDERS
P53 CODON 72 POLYMORPHISM
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in argentine patients.
Fil: Zarate, Ana Maria. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Don, Julieta. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Secchi, Dante Gustavo. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Carrica, Victoriano Andrés. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Galíndez Costa, María Fernanda. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Panico, René Luis. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Brusa, Martin Eduardo. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Barra, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Brunotto, Mabel Noemí. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
description The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in argentine patients.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/57507
Zarate, Ana Maria; Don, Julieta; Secchi, Dante Gustavo; Carrica, Victoriano Andrés; Galíndez Costa, María Fernanda; et al.; Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients; Karger; Tumor Biology; 39; 5; 5-2017
1010-4283
1423-0380
CONICET Digital
CONICET
url http://hdl.handle.net/11336/57507
identifier_str_mv Zarate, Ana Maria; Don, Julieta; Secchi, Dante Gustavo; Carrica, Victoriano Andrés; Galíndez Costa, María Fernanda; et al.; Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients; Karger; Tumor Biology; 39; 5; 5-2017
1010-4283
1423-0380
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1010428317699113
info:eu-repo/semantics/altIdentifier/doi/10.1177/1010428317699113
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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