Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
- Autores
- Scolari, Ivana Romina; Paez, Paulina L.; Granero, Gladys Ester
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Impact Factor: 3.4
Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore the synergistic effects of zinc oxide nanoparticles (ZnO NPs) in combination with GEN on the bactericidal activity against various bacterial strains. Results showed ZnO NPs with MICs ranging from 0.002 to 1.5 μg/mL, while the precursor salt displayed a MIC range of 48.75–1560 μg/mL. Chitosan (CS)-capped ZnO NPs exhibited even lower MICs than their uncapped counterparts, with the CS-capped synthesized ZnO NPs demonstrating the lowest values. Minimal bactericidal concentrations (MBC) aligned with MIC trends. Combinations of CS-capped synthesized ZnO NPs and GEN proved highly effective, inhibiting bacterial growth at significantly lower concentrations than GEN or ZnO NPs alone. This phenomenon may be attributed to the conformation of CS on the ZnO NPs' surface, enhancing the positive particle surface charge. This possibly facilitates a more effective interaction between ZnO NPs and microorganisms, leading to increased accumulation of zinc and GEN within bacterial cells and an overproduction of reactive oxygen species (ROS). It's crucial to note that, while this study did not specifically involve resistant strains, its primary focus remains on enhancing the overall antimicrobial activity of gentamicin. The research aims to contribute to addressing the global challenge of antimicrobial resistance, recognizing the urgent need for effective strategies to combat this critical issue. The findings, particularly the observed synergy between ZnO NPs and GEN, hold significant implications for repositioning the first-line antibiotic GEN.
info:eu-repo/semantics/publishedVersion
Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. - Materia
-
Gentamicin
Zinc oxide nanoparticles (ZnO NPs)
Synergic bactericidal activity
Reactive oxygen species (ROS) - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Universidad Nacional de Córdoba
- OAI Identificador
- oai:rdu.unc.edu.ar:11086/552767
Ver los metadatos del registro completo
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Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibioticScolari, Ivana RominaPaez, Paulina L.Granero, Gladys EsterGentamicinZinc oxide nanoparticles (ZnO NPs)Synergic bactericidal activityReactive oxygen species (ROS)Impact Factor: 3.4Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore the synergistic effects of zinc oxide nanoparticles (ZnO NPs) in combination with GEN on the bactericidal activity against various bacterial strains. Results showed ZnO NPs with MICs ranging from 0.002 to 1.5 μg/mL, while the precursor salt displayed a MIC range of 48.75–1560 μg/mL. Chitosan (CS)-capped ZnO NPs exhibited even lower MICs than their uncapped counterparts, with the CS-capped synthesized ZnO NPs demonstrating the lowest values. Minimal bactericidal concentrations (MBC) aligned with MIC trends. Combinations of CS-capped synthesized ZnO NPs and GEN proved highly effective, inhibiting bacterial growth at significantly lower concentrations than GEN or ZnO NPs alone. This phenomenon may be attributed to the conformation of CS on the ZnO NPs' surface, enhancing the positive particle surface charge. This possibly facilitates a more effective interaction between ZnO NPs and microorganisms, leading to increased accumulation of zinc and GEN within bacterial cells and an overproduction of reactive oxygen species (ROS). It's crucial to note that, while this study did not specifically involve resistant strains, its primary focus remains on enhancing the overall antimicrobial activity of gentamicin. The research aims to contribute to addressing the global challenge of antimicrobial resistance, recognizing the urgent need for effective strategies to combat this critical issue. The findings, particularly the observed synergy between ZnO NPs and GEN, hold significant implications for repositioning the first-line antibiotic GEN.info:eu-repo/semantics/publishedVersionFil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.https://orcid.org/0009-0004-0570-7053https://orcid.org/0000-0003-4836-4842https://orcid.org/0000-0003-2142-16752024-02-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfScolari, I. R., Páez, P. L., & Granero, G. E. (2024). Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic. Heliyon, 10(3).http://hdl.handle.net/11086/5527672405-8440https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/http://doi.org/10.1016/j.heliyon.2024.e25604enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-16T09:29:55Zoai:rdu.unc.edu.ar:11086/552767Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-16 09:29:55.591Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse |
dc.title.none.fl_str_mv |
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
title |
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
spellingShingle |
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic Scolari, Ivana Romina Gentamicin Zinc oxide nanoparticles (ZnO NPs) Synergic bactericidal activity Reactive oxygen species (ROS) |
title_short |
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
title_full |
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
title_fullStr |
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
title_full_unstemmed |
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
title_sort |
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
dc.creator.none.fl_str_mv |
Scolari, Ivana Romina Paez, Paulina L. Granero, Gladys Ester |
author |
Scolari, Ivana Romina |
author_facet |
Scolari, Ivana Romina Paez, Paulina L. Granero, Gladys Ester |
author_role |
author |
author2 |
Paez, Paulina L. Granero, Gladys Ester |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
https://orcid.org/0009-0004-0570-7053 https://orcid.org/0000-0003-4836-4842 https://orcid.org/0000-0003-2142-1675 |
dc.subject.none.fl_str_mv |
Gentamicin Zinc oxide nanoparticles (ZnO NPs) Synergic bactericidal activity Reactive oxygen species (ROS) |
topic |
Gentamicin Zinc oxide nanoparticles (ZnO NPs) Synergic bactericidal activity Reactive oxygen species (ROS) |
dc.description.none.fl_txt_mv |
Impact Factor: 3.4 Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore the synergistic effects of zinc oxide nanoparticles (ZnO NPs) in combination with GEN on the bactericidal activity against various bacterial strains. Results showed ZnO NPs with MICs ranging from 0.002 to 1.5 μg/mL, while the precursor salt displayed a MIC range of 48.75–1560 μg/mL. Chitosan (CS)-capped ZnO NPs exhibited even lower MICs than their uncapped counterparts, with the CS-capped synthesized ZnO NPs demonstrating the lowest values. Minimal bactericidal concentrations (MBC) aligned with MIC trends. Combinations of CS-capped synthesized ZnO NPs and GEN proved highly effective, inhibiting bacterial growth at significantly lower concentrations than GEN or ZnO NPs alone. This phenomenon may be attributed to the conformation of CS on the ZnO NPs' surface, enhancing the positive particle surface charge. This possibly facilitates a more effective interaction between ZnO NPs and microorganisms, leading to increased accumulation of zinc and GEN within bacterial cells and an overproduction of reactive oxygen species (ROS). It's crucial to note that, while this study did not specifically involve resistant strains, its primary focus remains on enhancing the overall antimicrobial activity of gentamicin. The research aims to contribute to addressing the global challenge of antimicrobial resistance, recognizing the urgent need for effective strategies to combat this critical issue. The findings, particularly the observed synergy between ZnO NPs and GEN, hold significant implications for repositioning the first-line antibiotic GEN. info:eu-repo/semantics/publishedVersion Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. |
description |
Impact Factor: 3.4 |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
status_str |
publishedVersion |
format |
article |
dc.identifier.none.fl_str_mv |
Scolari, I. R., Páez, P. L., & Granero, G. E. (2024). Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic. Heliyon, 10(3). http://hdl.handle.net/11086/552767 2405-8440 https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/ http://doi.org/10.1016/j.heliyon.2024.e25604 |
identifier_str_mv |
Scolari, I. R., Páez, P. L., & Granero, G. E. (2024). Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic. Heliyon, 10(3). 2405-8440 |
url |
http://hdl.handle.net/11086/552767 https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/ http://doi.org/10.1016/j.heliyon.2024.e25604 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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openAccess |
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Repositorio Digital Universitario (UNC) |
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Universidad Nacional de Córdoba |
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UNC |
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Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba |
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