Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic

Autores
Scolari, Ivana Romina; Paez, Paulina L.; Granero, Gladys Ester
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Impact Factor: 3.4
Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore the synergistic effects of zinc oxide nanoparticles (ZnO NPs) in combination with GEN on the bactericidal activity against various bacterial strains. Results showed ZnO NPs with MICs ranging from 0.002 to 1.5 μg/mL, while the precursor salt displayed a MIC range of 48.75–1560 μg/mL. Chitosan (CS)-capped ZnO NPs exhibited even lower MICs than their uncapped counterparts, with the CS-capped synthesized ZnO NPs demonstrating the lowest values. Minimal bactericidal concentrations (MBC) aligned with MIC trends. Combinations of CS-capped synthesized ZnO NPs and GEN proved highly effective, inhibiting bacterial growth at significantly lower concentrations than GEN or ZnO NPs alone. This phenomenon may be attributed to the conformation of CS on the ZnO NPs' surface, enhancing the positive particle surface charge. This possibly facilitates a more effective interaction between ZnO NPs and microorganisms, leading to increased accumulation of zinc and GEN within bacterial cells and an overproduction of reactive oxygen species (ROS). It's crucial to note that, while this study did not specifically involve resistant strains, its primary focus remains on enhancing the overall antimicrobial activity of gentamicin. The research aims to contribute to addressing the global challenge of antimicrobial resistance, recognizing the urgent need for effective strategies to combat this critical issue. The findings, particularly the observed synergy between ZnO NPs and GEN, hold significant implications for repositioning the first-line antibiotic GEN.
info:eu-repo/semantics/publishedVersion
Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Materia
Gentamicin
Zinc oxide nanoparticles (ZnO NPs)
Synergic bactericidal activity
Reactive oxygen species (ROS)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/552767

id RDUUNC_6a42f19785e6bab0db9250723e59a8a9
oai_identifier_str oai:rdu.unc.edu.ar:11086/552767
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibioticScolari, Ivana RominaPaez, Paulina L.Granero, Gladys EsterGentamicinZinc oxide nanoparticles (ZnO NPs)Synergic bactericidal activityReactive oxygen species (ROS)Impact Factor: 3.4Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore the synergistic effects of zinc oxide nanoparticles (ZnO NPs) in combination with GEN on the bactericidal activity against various bacterial strains. Results showed ZnO NPs with MICs ranging from 0.002 to 1.5 μg/mL, while the precursor salt displayed a MIC range of 48.75–1560 μg/mL. Chitosan (CS)-capped ZnO NPs exhibited even lower MICs than their uncapped counterparts, with the CS-capped synthesized ZnO NPs demonstrating the lowest values. Minimal bactericidal concentrations (MBC) aligned with MIC trends. Combinations of CS-capped synthesized ZnO NPs and GEN proved highly effective, inhibiting bacterial growth at significantly lower concentrations than GEN or ZnO NPs alone. This phenomenon may be attributed to the conformation of CS on the ZnO NPs' surface, enhancing the positive particle surface charge. This possibly facilitates a more effective interaction between ZnO NPs and microorganisms, leading to increased accumulation of zinc and GEN within bacterial cells and an overproduction of reactive oxygen species (ROS). It's crucial to note that, while this study did not specifically involve resistant strains, its primary focus remains on enhancing the overall antimicrobial activity of gentamicin. The research aims to contribute to addressing the global challenge of antimicrobial resistance, recognizing the urgent need for effective strategies to combat this critical issue. The findings, particularly the observed synergy between ZnO NPs and GEN, hold significant implications for repositioning the first-line antibiotic GEN.info:eu-repo/semantics/publishedVersionFil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.https://orcid.org/0009-0004-0570-7053https://orcid.org/0000-0003-4836-4842https://orcid.org/0000-0003-2142-16752024-02-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfScolari, I. R., Páez, P. L., & Granero, G. E. (2024). Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic. Heliyon, 10(3).http://hdl.handle.net/11086/5527672405-8440https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/http://doi.org/10.1016/j.heliyon.2024.e25604enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-16T09:29:55Zoai:rdu.unc.edu.ar:11086/552767Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-16 09:29:55.591Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
title Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
spellingShingle Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
Scolari, Ivana Romina
Gentamicin
Zinc oxide nanoparticles (ZnO NPs)
Synergic bactericidal activity
Reactive oxygen species (ROS)
title_short Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
title_full Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
title_fullStr Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
title_full_unstemmed Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
title_sort Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
dc.creator.none.fl_str_mv Scolari, Ivana Romina
Paez, Paulina L.
Granero, Gladys Ester
author Scolari, Ivana Romina
author_facet Scolari, Ivana Romina
Paez, Paulina L.
Granero, Gladys Ester
author_role author
author2 Paez, Paulina L.
Granero, Gladys Ester
author2_role author
author
dc.contributor.none.fl_str_mv https://orcid.org/0009-0004-0570-7053
https://orcid.org/0000-0003-4836-4842
https://orcid.org/0000-0003-2142-1675
dc.subject.none.fl_str_mv Gentamicin
Zinc oxide nanoparticles (ZnO NPs)
Synergic bactericidal activity
Reactive oxygen species (ROS)
topic Gentamicin
Zinc oxide nanoparticles (ZnO NPs)
Synergic bactericidal activity
Reactive oxygen species (ROS)
dc.description.none.fl_txt_mv Impact Factor: 3.4
Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore the synergistic effects of zinc oxide nanoparticles (ZnO NPs) in combination with GEN on the bactericidal activity against various bacterial strains. Results showed ZnO NPs with MICs ranging from 0.002 to 1.5 μg/mL, while the precursor salt displayed a MIC range of 48.75–1560 μg/mL. Chitosan (CS)-capped ZnO NPs exhibited even lower MICs than their uncapped counterparts, with the CS-capped synthesized ZnO NPs demonstrating the lowest values. Minimal bactericidal concentrations (MBC) aligned with MIC trends. Combinations of CS-capped synthesized ZnO NPs and GEN proved highly effective, inhibiting bacterial growth at significantly lower concentrations than GEN or ZnO NPs alone. This phenomenon may be attributed to the conformation of CS on the ZnO NPs' surface, enhancing the positive particle surface charge. This possibly facilitates a more effective interaction between ZnO NPs and microorganisms, leading to increased accumulation of zinc and GEN within bacterial cells and an overproduction of reactive oxygen species (ROS). It's crucial to note that, while this study did not specifically involve resistant strains, its primary focus remains on enhancing the overall antimicrobial activity of gentamicin. The research aims to contribute to addressing the global challenge of antimicrobial resistance, recognizing the urgent need for effective strategies to combat this critical issue. The findings, particularly the observed synergy between ZnO NPs and GEN, hold significant implications for repositioning the first-line antibiotic GEN.
info:eu-repo/semantics/publishedVersion
Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina.
description Impact Factor: 3.4
publishDate 2024
dc.date.none.fl_str_mv 2024-02-15
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
status_str publishedVersion
format article
dc.identifier.none.fl_str_mv Scolari, I. R., Páez, P. L., & Granero, G. E. (2024). Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic. Heliyon, 10(3).
http://hdl.handle.net/11086/552767
2405-8440
https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/
http://doi.org/10.1016/j.heliyon.2024.e25604
identifier_str_mv Scolari, I. R., Páez, P. L., & Granero, G. E. (2024). Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic. Heliyon, 10(3).
2405-8440
url http://hdl.handle.net/11086/552767
https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/
http://doi.org/10.1016/j.heliyon.2024.e25604
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
_version_ 1846143369527427072
score 12.712165