Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp

Autores
Decarlini, M. F.; Vázquez, A. M.; Aimar, M. L.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fil: Decarlini, M. F. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
Fil: Vázquez, A. M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
Fil: Aimar, M. L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Aplicada; Argentina.
Nowadays, biocatalytic stereoselective reduction of prochiral ketones is one of the most important methodologies in organic synthesis for the preparation of chiral alcohols. These enantiomerically pure alcohols are very important because they are key precursors in the obtaining of pharmaceutical compounds. Recently, a screening on fifty six strains of bacteria and fungi was made for our team toidentify microorganisms capable of performing the stereoselective reduction of acetophenone (AP) to 1-phenylethanol (1-PE). From this study a strain of Geotrichum spp.has been isolated and characterized, and this yeast has presented anexcellent conversion (>99%) and stereoselectivity (>99.9 e.e.%) in the preparation of (R)-1-PE from AP.
Fil: Decarlini, M. F. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
Fil: Vázquez, A. M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
Fil: Aimar, M. L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Aplicada; Argentina.
Otras Ciencias Químicas
Materia
Biocatalysis
Bioreduction
Prochiral ketones
Ciencias Químicas
Química Aplicada
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/550480
Acceder
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oai_identifier_str oai:rdu.unc.edu.ar:11086/550480
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum sppDecarlini, M. F.Vázquez, A. M.Aimar, M. L.BiocatalysisBioreductionProchiral ketonesCiencias QuímicasQuímica AplicadaFil: Decarlini, M. F. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Vázquez, A. M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Aimar, M. L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Aplicada; Argentina.Nowadays, biocatalytic stereoselective reduction of prochiral ketones is one of the most important methodologies in organic synthesis for the preparation of chiral alcohols. These enantiomerically pure alcohols are very important because they are key precursors in the obtaining of pharmaceutical compounds. Recently, a screening on fifty six strains of bacteria and fungi was made for our team toidentify microorganisms capable of performing the stereoselective reduction of acetophenone (AP) to 1-phenylethanol (1-PE). From this study a strain of Geotrichum spp.has been isolated and characterized, and this yeast has presented anexcellent conversion (>99%) and stereoselectivity (>99.9 e.e.%) in the preparation of (R)-1-PE from AP.Fil: Decarlini, M. F. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Vázquez, A. M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Aimar, M. L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Aplicada; Argentina.Otras Ciencias Químicas2015info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/550480enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-16T09:30:23Zoai:rdu.unc.edu.ar:11086/550480Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-16 09:30:23.888Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
title Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
spellingShingle Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
Decarlini, M. F.
Biocatalysis
Bioreduction
Prochiral ketones
Ciencias Químicas
Química Aplicada
title_short Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
title_full Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
title_fullStr Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
title_full_unstemmed Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
title_sort Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
dc.creator.none.fl_str_mv Decarlini, M. F.
Vázquez, A. M.
Aimar, M. L.
author Decarlini, M. F.
author_facet Decarlini, M. F.
Vázquez, A. M.
Aimar, M. L.
author_role author
author2 Vázquez, A. M.
Aimar, M. L.
author2_role author
author
dc.subject.none.fl_str_mv Biocatalysis
Bioreduction
Prochiral ketones
Ciencias Químicas
Química Aplicada
topic Biocatalysis
Bioreduction
Prochiral ketones
Ciencias Químicas
Química Aplicada
dc.description.none.fl_txt_mv Fil: Decarlini, M. F. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
Fil: Vázquez, A. M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
Fil: Aimar, M. L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Aplicada; Argentina.
Nowadays, biocatalytic stereoselective reduction of prochiral ketones is one of the most important methodologies in organic synthesis for the preparation of chiral alcohols. These enantiomerically pure alcohols are very important because they are key precursors in the obtaining of pharmaceutical compounds. Recently, a screening on fifty six strains of bacteria and fungi was made for our team toidentify microorganisms capable of performing the stereoselective reduction of acetophenone (AP) to 1-phenylethanol (1-PE). From this study a strain of Geotrichum spp.has been isolated and characterized, and this yeast has presented anexcellent conversion (>99%) and stereoselectivity (>99.9 e.e.%) in the preparation of (R)-1-PE from AP.
Fil: Decarlini, M. F. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
Fil: Vázquez, A. M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
Fil: Aimar, M. L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Aplicada; Argentina.
Otras Ciencias Químicas
description Fil: Decarlini, M. F. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
format conferenceObject
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11086/550480
url http://hdl.handle.net/11086/550480
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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