From genetic alterations to new molecular targets in pituitary disorders

Autores
Ferraris, Jimena; Perez Millan, María Inés; Petiti, Juan Pablo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
3.9 Impact Factor
Fil: Ferraris, Jimena. Stockholm University. Department of Biophysics and Biochemistry; Suecia.
Fil: Pérez Millan, María Inés. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biociencia, Biotecnología y Biología Traslacional. Departamento de Fisiología, Biología Molecular y Celular; Argentina.
Fil: Petiti, Juan Pablo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Centro de Microscopía Electrónica; Argentina.
Fil: Petiti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
The pituitary gland is a central regulator of growth, reproduction and stress among other physiological functions through the secretion of five different hormone-producing cells types. A main characteristic of the anterior pituitary gland is its plasticity, which allows to adjust to different physiological conditions related to endocrine demands. Hormones are secreted by specific cells in the pituitary gland and this secretion is pulsatile (1). Pulses of pituitary hormones are generated and modified at multiple levels. From a therapeutic point of view, efforts are being focused on the study of normal hypothalamic-pituitary axes function and how dysregulation occurs in a disease context. This is particularly relevant to pituitary tumors, where hormone output is largely independent of hypothalamic stimulation (2).
info:eu-repo/semantics/publishedVersion
Fil: Ferraris, Jimena. Stockholm University. Department of Biophysics and Biochemistry; Suecia.
Fil: Pérez Millan, María Inés. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biociencia, Biotecnología y Biología Traslacional. Departamento de Fisiología, Biología Molecular y Celular; Argentina.
Fil: Petiti, Juan Pablo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Centro de Microscopía Electrónica; Argentina.
Fil: Petiti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
Materia
Pituitary plasticity
Pituitary tumors
Wnt/b-catenin pathway
Sphingosine-1phosphate
Low blood testosterone level
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/552688
Acceder
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repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling From genetic alterations to new molecular targets in pituitary disordersFerraris, JimenaPerez Millan, María InésPetiti, Juan PabloPituitary plasticityPituitary tumorsWnt/b-catenin pathwaySphingosine-1phosphateLow blood testosterone level3.9 Impact FactorFil: Ferraris, Jimena. Stockholm University. Department of Biophysics and Biochemistry; Suecia.Fil: Pérez Millan, María Inés. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biociencia, Biotecnología y Biología Traslacional. Departamento de Fisiología, Biología Molecular y Celular; Argentina.Fil: Petiti, Juan Pablo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Centro de Microscopía Electrónica; Argentina.Fil: Petiti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.The pituitary gland is a central regulator of growth, reproduction and stress among other physiological functions through the secretion of five different hormone-producing cells types. A main characteristic of the anterior pituitary gland is its plasticity, which allows to adjust to different physiological conditions related to endocrine demands. Hormones are secreted by specific cells in the pituitary gland and this secretion is pulsatile (1). Pulses of pituitary hormones are generated and modified at multiple levels. From a therapeutic point of view, efforts are being focused on the study of normal hypothalamic-pituitary axes function and how dysregulation occurs in a disease context. This is particularly relevant to pituitary tumors, where hormone output is largely independent of hypothalamic stimulation (2).info:eu-repo/semantics/publishedVersionFil: Ferraris, Jimena. Stockholm University. Department of Biophysics and Biochemistry; Suecia.Fil: Pérez Millan, María Inés. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biociencia, Biotecnología y Biología Traslacional. Departamento de Fisiología, Biología Molecular y Celular; Argentina.Fil: Petiti, Juan Pablo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Centro de Microscopía Electrónica; Argentina.Fil: Petiti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.https://orcid.org/0000-0001-7472-0439https://orcid.org/0000-0002-0486-109Xhttps://orcid.org/0000-0002-8555-34262024-02-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfFerraris J, Perez-Millan MI and Petiti JP (2024) Editorial: From genetic alterations to new molecular targets in pituitary disorders. Front. Endocrinol. 15:1375475. doi: 10.3389/fendo.2024.13754751664-2392http://hdl.handle.net/11086/552688https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1375475/fullhttps://doi.org/10.3389/fendo.2024.1375475enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-04T12:34:00Zoai:rdu.unc.edu.ar:11086/552688Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-04 12:34:01.182Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv From genetic alterations to new molecular targets in pituitary disorders
title From genetic alterations to new molecular targets in pituitary disorders
spellingShingle From genetic alterations to new molecular targets in pituitary disorders
Ferraris, Jimena
Pituitary plasticity
Pituitary tumors
Wnt/b-catenin pathway
Sphingosine-1phosphate
Low blood testosterone level
title_short From genetic alterations to new molecular targets in pituitary disorders
title_full From genetic alterations to new molecular targets in pituitary disorders
title_fullStr From genetic alterations to new molecular targets in pituitary disorders
title_full_unstemmed From genetic alterations to new molecular targets in pituitary disorders
title_sort From genetic alterations to new molecular targets in pituitary disorders
dc.creator.none.fl_str_mv Ferraris, Jimena
Perez Millan, María Inés
Petiti, Juan Pablo
author Ferraris, Jimena
author_facet Ferraris, Jimena
Perez Millan, María Inés
Petiti, Juan Pablo
author_role author
author2 Perez Millan, María Inés
Petiti, Juan Pablo
author2_role author
author
dc.contributor.none.fl_str_mv https://orcid.org/0000-0001-7472-0439
https://orcid.org/0000-0002-0486-109X
https://orcid.org/0000-0002-8555-3426
dc.subject.none.fl_str_mv Pituitary plasticity
Pituitary tumors
Wnt/b-catenin pathway
Sphingosine-1phosphate
Low blood testosterone level
topic Pituitary plasticity
Pituitary tumors
Wnt/b-catenin pathway
Sphingosine-1phosphate
Low blood testosterone level
dc.description.none.fl_txt_mv 3.9 Impact Factor
Fil: Ferraris, Jimena. Stockholm University. Department of Biophysics and Biochemistry; Suecia.
Fil: Pérez Millan, María Inés. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biociencia, Biotecnología y Biología Traslacional. Departamento de Fisiología, Biología Molecular y Celular; Argentina.
Fil: Petiti, Juan Pablo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Centro de Microscopía Electrónica; Argentina.
Fil: Petiti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
The pituitary gland is a central regulator of growth, reproduction and stress among other physiological functions through the secretion of five different hormone-producing cells types. A main characteristic of the anterior pituitary gland is its plasticity, which allows to adjust to different physiological conditions related to endocrine demands. Hormones are secreted by specific cells in the pituitary gland and this secretion is pulsatile (1). Pulses of pituitary hormones are generated and modified at multiple levels. From a therapeutic point of view, efforts are being focused on the study of normal hypothalamic-pituitary axes function and how dysregulation occurs in a disease context. This is particularly relevant to pituitary tumors, where hormone output is largely independent of hypothalamic stimulation (2).
info:eu-repo/semantics/publishedVersion
Fil: Ferraris, Jimena. Stockholm University. Department of Biophysics and Biochemistry; Suecia.
Fil: Pérez Millan, María Inés. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biociencia, Biotecnología y Biología Traslacional. Departamento de Fisiología, Biología Molecular y Celular; Argentina.
Fil: Petiti, Juan Pablo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Centro de Microscopía Electrónica; Argentina.
Fil: Petiti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.
description 3.9 Impact Factor
publishDate 2024
dc.date.none.fl_str_mv 2024-02-07
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
status_str publishedVersion
format article
dc.identifier.none.fl_str_mv Ferraris J, Perez-Millan MI and Petiti JP (2024) Editorial: From genetic alterations to new molecular targets in pituitary disorders. Front. Endocrinol. 15:1375475. doi: 10.3389/fendo.2024.1375475
1664-2392
http://hdl.handle.net/11086/552688
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1375475/full
https://doi.org/10.3389/fendo.2024.1375475
identifier_str_mv Ferraris J, Perez-Millan MI and Petiti JP (2024) Editorial: From genetic alterations to new molecular targets in pituitary disorders. Front. Endocrinol. 15:1375475. doi: 10.3389/fendo.2024.1375475
1664-2392
url http://hdl.handle.net/11086/552688
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1375475/full
https://doi.org/10.3389/fendo.2024.1375475
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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score 13.13397

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