Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)

Autores
Trakal, Esteban; Guidi, Andrés Emilio; Butti, Abel Luis L.; Trakal, Juan José; Sambuelli, Rubén Horacio; Zárate, Fabián Eduardo
Año de publicación
2010
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
The rising incidence of adenocarcinoma in Barrett's esophagus has intensified the research into methods of early recognition of cancer risk, detecting cytological and architectural changes (dysplasia) or using biomarkers as predictive tests. The aim of this paper is to evaluate the involvement of two tumor markers: p53 (tumor suppressor gene) and Ki67 (proliferation marker), by means of immunohistochemical analysis with monoclonal antibodies designed for the specific localization of p53 and Ki67 antigens, in esophageal biopsies with columnar metaplasia of patients with and without dysplasia and adenocarcinoma, and to anticipate which ones are liable to suffer it in the future. Both markers were positive in all intestinal metaplasia patients with high-grade dysplasia and adenocarcinoma, and even in some cases with low grade or without dysplasia. In contrast, in those who have gastric metaplasia, tumor markers were negative. Expression of biomarkers next to dysplasia reduces interobserver variation. Patients with these abnormalities have to be included into a surveillance protocol.
Fil: Trakal, Esteban. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Guidi, Andrés Emilio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Butti, Abel Luis L. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Trakal, Juan José. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Sambuelli, Rubén Horacio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Zárate, Fabián Eduardo. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fuente
Trakal, Esteban ORCID: https://orcid.org/0000-0001-9786-6449 , Guidi, Andrés Emilio, Butti, Abel Luis L., Trakal, Juan José ORCID: https://orcid.org/0000-0003-4892-7449 , Sambuelli, Rubén Horacio and Zárate, Fabián Eduardo (2010) Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67). Acta Gastroenterológica Latinoamericana, 40 (3). pp. 211-215. ISSN 0300-9033
Materia
R Medicina (General)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Repositorio
Producción Académica (UCC)
Institución
Universidad Católica de Córdoba
OAI Identificador
oai:pa.bibdigital.uccor.edu.ar:3444
Acceder
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oai_identifier_str oai:pa.bibdigital.uccor.edu.ar:3444
network_acronym_str PAUCC
repository_id_str 2718
network_name_str Producción Académica (UCC)
spelling Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)Trakal, EstebanGuidi, Andrés EmilioButti, Abel Luis L.Trakal, Juan JoséSambuelli, Rubén HoracioZárate, Fabián EduardoR Medicina (General)The rising incidence of adenocarcinoma in Barrett's esophagus has intensified the research into methods of early recognition of cancer risk, detecting cytological and architectural changes (dysplasia) or using biomarkers as predictive tests. The aim of this paper is to evaluate the involvement of two tumor markers: p53 (tumor suppressor gene) and Ki67 (proliferation marker), by means of immunohistochemical analysis with monoclonal antibodies designed for the specific localization of p53 and Ki67 antigens, in esophageal biopsies with columnar metaplasia of patients with and without dysplasia and adenocarcinoma, and to anticipate which ones are liable to suffer it in the future. Both markers were positive in all intestinal metaplasia patients with high-grade dysplasia and adenocarcinoma, and even in some cases with low grade or without dysplasia. In contrast, in those who have gastric metaplasia, tumor markers were negative. Expression of biomarkers next to dysplasia reduces interobserver variation. Patients with these abnormalities have to be included into a surveillance protocol.Fil: Trakal, Esteban. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Guidi, Andrés Emilio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Butti, Abel Luis L. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Trakal, Juan José. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Sambuelli, Rubén Horacio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Zárate, Fabián Eduardo. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaSociedad Argentina de Gastroenterología2010-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://pa.bibdigital.ucc.edu.ar/3444/1/A_Trakal_Guidi_Butti_Trakal_Sambuelli_Zarate.pdf Trakal, Esteban ORCID: https://orcid.org/0000-0001-9786-6449 <https://orcid.org/0000-0001-9786-6449>, Guidi, Andrés Emilio, Butti, Abel Luis L., Trakal, Juan José ORCID: https://orcid.org/0000-0003-4892-7449 <https://orcid.org/0000-0003-4892-7449>, Sambuelli, Rubén Horacio and Zárate, Fabián Eduardo (2010) Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67). Acta Gastroenterológica Latinoamericana, 40 (3). pp. 211-215. ISSN 0300-9033 reponame:Producción Académica (UCC)instname:Universidad Católica de Córdobaspahttp://pa.bibdigital.ucc.edu.ar/3444/https://www.redalyc.org/articulo.oa?id=199314783006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es2025-10-23T11:17:50Zoai:pa.bibdigital.uccor.edu.ar:3444instacron:UCCInstitucionalhttp://pa.bibdigital.uccor.edu.ar/Universidad privadaNo correspondehttp://pa.bibdigital.uccor.edu.ar/cgi/oai2bibdir@uccor.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:27182025-10-23 11:17:51.342Producción Académica (UCC) - Universidad Católica de Córdobafalse
dc.title.none.fl_str_mv Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
spellingShingle Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
Trakal, Esteban
R Medicina (General)
title_short Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_full Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_fullStr Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_full_unstemmed Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_sort Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
dc.creator.none.fl_str_mv Trakal, Esteban
Guidi, Andrés Emilio
Butti, Abel Luis L.
Trakal, Juan José
Sambuelli, Rubén Horacio
Zárate, Fabián Eduardo
author Trakal, Esteban
author_facet Trakal, Esteban
Guidi, Andrés Emilio
Butti, Abel Luis L.
Trakal, Juan José
Sambuelli, Rubén Horacio
Zárate, Fabián Eduardo
author_role author
author2 Guidi, Andrés Emilio
Butti, Abel Luis L.
Trakal, Juan José
Sambuelli, Rubén Horacio
Zárate, Fabián Eduardo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv R Medicina (General)
topic R Medicina (General)
dc.description.none.fl_txt_mv The rising incidence of adenocarcinoma in Barrett's esophagus has intensified the research into methods of early recognition of cancer risk, detecting cytological and architectural changes (dysplasia) or using biomarkers as predictive tests. The aim of this paper is to evaluate the involvement of two tumor markers: p53 (tumor suppressor gene) and Ki67 (proliferation marker), by means of immunohistochemical analysis with monoclonal antibodies designed for the specific localization of p53 and Ki67 antigens, in esophageal biopsies with columnar metaplasia of patients with and without dysplasia and adenocarcinoma, and to anticipate which ones are liable to suffer it in the future. Both markers were positive in all intestinal metaplasia patients with high-grade dysplasia and adenocarcinoma, and even in some cases with low grade or without dysplasia. In contrast, in those who have gastric metaplasia, tumor markers were negative. Expression of biomarkers next to dysplasia reduces interobserver variation. Patients with these abnormalities have to be included into a surveillance protocol.
Fil: Trakal, Esteban. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Guidi, Andrés Emilio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Butti, Abel Luis L. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Trakal, Juan José. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Sambuelli, Rubén Horacio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Zárate, Fabián Eduardo. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
description The rising incidence of adenocarcinoma in Barrett's esophagus has intensified the research into methods of early recognition of cancer risk, detecting cytological and architectural changes (dysplasia) or using biomarkers as predictive tests. The aim of this paper is to evaluate the involvement of two tumor markers: p53 (tumor suppressor gene) and Ki67 (proliferation marker), by means of immunohistochemical analysis with monoclonal antibodies designed for the specific localization of p53 and Ki67 antigens, in esophageal biopsies with columnar metaplasia of patients with and without dysplasia and adenocarcinoma, and to anticipate which ones are liable to suffer it in the future. Both markers were positive in all intestinal metaplasia patients with high-grade dysplasia and adenocarcinoma, and even in some cases with low grade or without dysplasia. In contrast, in those who have gastric metaplasia, tumor markers were negative. Expression of biomarkers next to dysplasia reduces interobserver variation. Patients with these abnormalities have to be included into a surveillance protocol.
publishDate 2010
dc.date.none.fl_str_mv 2010-09-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://pa.bibdigital.ucc.edu.ar/3444/1/A_Trakal_Guidi_Butti_Trakal_Sambuelli_Zarate.pdf
url http://pa.bibdigital.ucc.edu.ar/3444/1/A_Trakal_Guidi_Butti_Trakal_Sambuelli_Zarate.pdf
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv http://pa.bibdigital.ucc.edu.ar/3444/
https://www.redalyc.org/articulo.oa?id=199314783006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Gastroenterología
publisher.none.fl_str_mv Sociedad Argentina de Gastroenterología
dc.source.none.fl_str_mv Trakal, Esteban ORCID: https://orcid.org/0000-0001-9786-6449 <https://orcid.org/0000-0001-9786-6449>, Guidi, Andrés Emilio, Butti, Abel Luis L., Trakal, Juan José ORCID: https://orcid.org/0000-0003-4892-7449 <https://orcid.org/0000-0003-4892-7449>, Sambuelli, Rubén Horacio and Zárate, Fabián Eduardo (2010) Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67). Acta Gastroenterológica Latinoamericana, 40 (3). pp. 211-215. ISSN 0300-9033
reponame:Producción Académica (UCC)
instname:Universidad Católica de Córdoba
reponame_str Producción Académica (UCC)
collection Producción Académica (UCC)
instname_str Universidad Católica de Córdoba
repository.name.fl_str_mv Producción Académica (UCC) - Universidad Católica de Córdoba
repository.mail.fl_str_mv bibdir@uccor.edu.ar
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score 12.982451

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