Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines
- Autores
- Bucafusco, Danilo; Di Giacomo, Sebastián; Pega, Juan Franco; Juncos, María Sol; Schammas, Juan Manuel; Perez Filgueira, Daniel Mariano; Capozzo, Alejandra Victoria
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred through colostrum (Mat-Abs) in the immune responses of vaccinated calves is less clear. Here, we report the anti-FMDV humoral responses elicited in calves with or without Mat-Abs that received one or two doses of the current tetravalent oil-adjuvanted commercial vaccine used in Argentina. Anti-FMDV (O1/Campos strain) antibodies (Abs) were evaluated by Liquid Phase Blocking ELISA (LPB-ELISA), virus neutralization test (VNT), isotype ELISA (IgG1, IgG2 and IgM) and avidity ELISA, to allow for the first time a more detailed description of the humoral responses elicited. Our results show that primary IgM responses to FMDV vaccination only became evident as Mat-Abs titers decreased. Likewise, prime and boost vaccination schedules, applied 35 days apart to groups of calves with high or low levels of Mat-Abs, showed that the levels of preexisting neutralizing Mat-Abs prevented the loss of total Abs measured by LPB-ELISA but negatively interfered with the induction of virus neutralizing responses. Altogether, these findings indicate that comprehensive serological characterization of immune responses generated after vaccination in calves may reveal important information on the actual effectiveness of vaccination strategies for young animals, particularly in endemic settings.
Instituto de Virología
Fil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Pega, Juan Franco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Juncos, María Sol. Médica Veterinaria Independiente; Argentina
Fil: Schammas, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Fuente
- Vaccine 32 (48) : 6576-6582. (November 2014)
- Materia
-
Ternero
Enfermedades de los Animales
Fiebre Aftosa
Anticuerpos
Calostro
Respuesta Inmunológica
Vacuna
Calves
Animal Diseases
Foot and Mouth Disease
Antibodies
Colostrum
Immune Response
Vaccines - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- Repositorio
.jpg)
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/2515
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Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccinesBucafusco, DaniloDi Giacomo, SebastiánPega, Juan FrancoJuncos, María SolSchammas, Juan ManuelPerez Filgueira, Daniel MarianoCapozzo, Alejandra VictoriaTerneroEnfermedades de los AnimalesFiebre AftosaAnticuerposCalostroRespuesta InmunológicaVacunaCalvesAnimal DiseasesFoot and Mouth DiseaseAntibodiesColostrumImmune ResponseVaccinesImmunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred through colostrum (Mat-Abs) in the immune responses of vaccinated calves is less clear. Here, we report the anti-FMDV humoral responses elicited in calves with or without Mat-Abs that received one or two doses of the current tetravalent oil-adjuvanted commercial vaccine used in Argentina. Anti-FMDV (O1/Campos strain) antibodies (Abs) were evaluated by Liquid Phase Blocking ELISA (LPB-ELISA), virus neutralization test (VNT), isotype ELISA (IgG1, IgG2 and IgM) and avidity ELISA, to allow for the first time a more detailed description of the humoral responses elicited. Our results show that primary IgM responses to FMDV vaccination only became evident as Mat-Abs titers decreased. Likewise, prime and boost vaccination schedules, applied 35 days apart to groups of calves with high or low levels of Mat-Abs, showed that the levels of preexisting neutralizing Mat-Abs prevented the loss of total Abs measured by LPB-ELISA but negatively interfered with the induction of virus neutralizing responses. Altogether, these findings indicate that comprehensive serological characterization of immune responses generated after vaccination in calves may reveal important information on the actual effectiveness of vaccination strategies for young animals, particularly in endemic settings.Instituto de VirologíaFil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Pega, Juan Franco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Juncos, María Sol. Médica Veterinaria Independiente; ArgentinaFil: Schammas, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina2018-05-30T13:15:25Z2018-05-30T13:15:25Z2014-11-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.sciencedirect.com/science/article/pii/S0264410X14008573http://hdl.handle.net/20.500.12123/25150264-410Xhttps://doi.org/10.1016/j.vaccine.2014.06.056Vaccine 32 (48) : 6576-6582. (November 2014)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-11-06T09:39:32Zoai:localhost:20.500.12123/2515instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-11-06 09:39:34.233INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
| dc.title.none.fl_str_mv |
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title |
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| spellingShingle |
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines Bucafusco, Danilo Ternero Enfermedades de los Animales Fiebre Aftosa Anticuerpos Calostro Respuesta Inmunológica Vacuna Calves Animal Diseases Foot and Mouth Disease Antibodies Colostrum Immune Response Vaccines |
| title_short |
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_full |
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_fullStr |
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_full_unstemmed |
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_sort |
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| dc.creator.none.fl_str_mv |
Bucafusco, Danilo Di Giacomo, Sebastián Pega, Juan Franco Juncos, María Sol Schammas, Juan Manuel Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria |
| author |
Bucafusco, Danilo |
| author_facet |
Bucafusco, Danilo Di Giacomo, Sebastián Pega, Juan Franco Juncos, María Sol Schammas, Juan Manuel Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria |
| author_role |
author |
| author2 |
Di Giacomo, Sebastián Pega, Juan Franco Juncos, María Sol Schammas, Juan Manuel Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Ternero Enfermedades de los Animales Fiebre Aftosa Anticuerpos Calostro Respuesta Inmunológica Vacuna Calves Animal Diseases Foot and Mouth Disease Antibodies Colostrum Immune Response Vaccines |
| topic |
Ternero Enfermedades de los Animales Fiebre Aftosa Anticuerpos Calostro Respuesta Inmunológica Vacuna Calves Animal Diseases Foot and Mouth Disease Antibodies Colostrum Immune Response Vaccines |
| dc.description.none.fl_txt_mv |
Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred through colostrum (Mat-Abs) in the immune responses of vaccinated calves is less clear. Here, we report the anti-FMDV humoral responses elicited in calves with or without Mat-Abs that received one or two doses of the current tetravalent oil-adjuvanted commercial vaccine used in Argentina. Anti-FMDV (O1/Campos strain) antibodies (Abs) were evaluated by Liquid Phase Blocking ELISA (LPB-ELISA), virus neutralization test (VNT), isotype ELISA (IgG1, IgG2 and IgM) and avidity ELISA, to allow for the first time a more detailed description of the humoral responses elicited. Our results show that primary IgM responses to FMDV vaccination only became evident as Mat-Abs titers decreased. Likewise, prime and boost vaccination schedules, applied 35 days apart to groups of calves with high or low levels of Mat-Abs, showed that the levels of preexisting neutralizing Mat-Abs prevented the loss of total Abs measured by LPB-ELISA but negatively interfered with the induction of virus neutralizing responses. Altogether, these findings indicate that comprehensive serological characterization of immune responses generated after vaccination in calves may reveal important information on the actual effectiveness of vaccination strategies for young animals, particularly in endemic settings. Instituto de Virología Fil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Pega, Juan Franco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Juncos, María Sol. Médica Veterinaria Independiente; Argentina Fil: Schammas, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| description |
Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred through colostrum (Mat-Abs) in the immune responses of vaccinated calves is less clear. Here, we report the anti-FMDV humoral responses elicited in calves with or without Mat-Abs that received one or two doses of the current tetravalent oil-adjuvanted commercial vaccine used in Argentina. Anti-FMDV (O1/Campos strain) antibodies (Abs) were evaluated by Liquid Phase Blocking ELISA (LPB-ELISA), virus neutralization test (VNT), isotype ELISA (IgG1, IgG2 and IgM) and avidity ELISA, to allow for the first time a more detailed description of the humoral responses elicited. Our results show that primary IgM responses to FMDV vaccination only became evident as Mat-Abs titers decreased. Likewise, prime and boost vaccination schedules, applied 35 days apart to groups of calves with high or low levels of Mat-Abs, showed that the levels of preexisting neutralizing Mat-Abs prevented the loss of total Abs measured by LPB-ELISA but negatively interfered with the induction of virus neutralizing responses. Altogether, these findings indicate that comprehensive serological characterization of immune responses generated after vaccination in calves may reveal important information on the actual effectiveness of vaccination strategies for young animals, particularly in endemic settings. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-11-12 2018-05-30T13:15:25Z 2018-05-30T13:15:25Z |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S0264410X14008573 http://hdl.handle.net/20.500.12123/2515 0264-410X https://doi.org/10.1016/j.vaccine.2014.06.056 |
| url |
https://www.sciencedirect.com/science/article/pii/S0264410X14008573 http://hdl.handle.net/20.500.12123/2515 https://doi.org/10.1016/j.vaccine.2014.06.056 |
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0264-410X |
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eng |
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eng |
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info:eu-repo/semantics/restrictedAccess |
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restrictedAccess |
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application/pdf |
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INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
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tripaldi.nicolas@inta.gob.ar |
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