Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America

Autores
Marandino, Ana; Vagnozzi, Ariel Eduardo; Tomás, Gonzalo; Techera, Claudia; Gerez Miranda, Rocio Del Carmen; Hernández, Martín; Williman, Joaquín; Realpe, Mauricio; Greif, Gonzalo; Panzera, Yanina; Pérez, Ruben
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America. GI-11 is endemic to South America, and the GI-16 is globally distributed. We obtained full-length IBV genomes from Argentine and Uruguayan farms using Illumina sequencing. Genomes of the GI-11 and GI-16 lineages from Argentina and Uruguay differ in part of the spike coding region. The remaining genome regions are similar to the Chinese and Italian strains of the GI-16 lineage that emerged in Asia or Europe in the 1970s. Our findings support that the indigenous GI-11 strains recombine extensively with the invasive GI-16 strains. During the recombination process, GI-11 acquired most of the sequences of the GI-16, retaining the original S1 sequence. GI-11 strains with recombinant genomes are circulating forms that underwent further local evolution. The current IBV scenario in South America includes the GI-16 lineage, recombinant GI-11 strains sharing high similarity with GI-16 outside S1, and Brazilian GI-11 strains with a divergent genomic background. There is also sporadic recombinant in the GI-11 and GI-16 lineages among vaccine and field strains. Our findings exemplified the ability of IBV to generate emergent lineage by using the S gene in different genomic backgrounds. This unique example of recombinational microevolution underscores the genomic plasticity of IBV in South America.
Instituto de Virología
Fil: Marandino, Ana. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Vagnozzi, Ariel Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Tomás, Gonzalo. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Techera, Claudia. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Gerez Miranda, Rocio Del Carmen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Hernández, Martín. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Williman, Joaquín. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Realpe, Mauricio. Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias; México
Fil: Greif, Gonzalo. Instituto Pasteur de Montevideo. Unidad de Biología Molecular; Uruguay
Fil: Panzera, Yanina. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Pérez, Ruben. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fuente
Viruses 14 (10) : 2095 (Octubre 2022)
Materia
Bronchitis
Lineage
Recombination
Mutation
Avian Infectious Bronchitis Virus
South America
Bronquitis
Linaje
Recombinación
Mutación
Virus Bronquitis Infecciosa Aviar
América del Sur
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/16368
Acceder
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oai_identifier_str oai:localhost:20.500.12123/16368
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South AmericaMarandino, AnaVagnozzi, Ariel EduardoTomás, GonzaloTechera, ClaudiaGerez Miranda, Rocio Del CarmenHernández, MartínWilliman, JoaquínRealpe, MauricioGreif, GonzaloPanzera, YaninaPérez, RubenBronchitisLineageRecombinationMutationAvian Infectious Bronchitis VirusSouth AmericaBronquitisLinajeRecombinaciónMutaciónVirus Bronquitis Infecciosa AviarAmérica del SurThe gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America. GI-11 is endemic to South America, and the GI-16 is globally distributed. We obtained full-length IBV genomes from Argentine and Uruguayan farms using Illumina sequencing. Genomes of the GI-11 and GI-16 lineages from Argentina and Uruguay differ in part of the spike coding region. The remaining genome regions are similar to the Chinese and Italian strains of the GI-16 lineage that emerged in Asia or Europe in the 1970s. Our findings support that the indigenous GI-11 strains recombine extensively with the invasive GI-16 strains. During the recombination process, GI-11 acquired most of the sequences of the GI-16, retaining the original S1 sequence. GI-11 strains with recombinant genomes are circulating forms that underwent further local evolution. The current IBV scenario in South America includes the GI-16 lineage, recombinant GI-11 strains sharing high similarity with GI-16 outside S1, and Brazilian GI-11 strains with a divergent genomic background. There is also sporadic recombinant in the GI-11 and GI-16 lineages among vaccine and field strains. Our findings exemplified the ability of IBV to generate emergent lineage by using the S gene in different genomic backgrounds. This unique example of recombinational microevolution underscores the genomic plasticity of IBV in South America.Instituto de VirologíaFil: Marandino, Ana. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Vagnozzi, Ariel Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Tomás, Gonzalo. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Techera, Claudia. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Gerez Miranda, Rocio Del Carmen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Hernández, Martín. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Williman, Joaquín. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Realpe, Mauricio. Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias; MéxicoFil: Greif, Gonzalo. Instituto Pasteur de Montevideo. Unidad de Biología Molecular; UruguayFil: Panzera, Yanina. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Pérez, Ruben. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; UruguayMDPI2023-12-27T14:38:15Z2023-12-27T14:38:15Z2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/16368https://www.mdpi.com/1999-4915/14/10/20951999-4915https://doi.org/10.3390/v14102095Viruses 14 (10) : 2095 (Octubre 2022)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:31:26Zoai:localhost:20.500.12123/16368instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:31:27.051INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
title Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
spellingShingle Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
Marandino, Ana
Bronchitis
Lineage
Recombination
Mutation
Avian Infectious Bronchitis Virus
South America
Bronquitis
Linaje
Recombinación
Mutación
Virus Bronquitis Infecciosa Aviar
América del Sur
title_short Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
title_full Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
title_fullStr Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
title_full_unstemmed Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
title_sort Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
dc.creator.none.fl_str_mv Marandino, Ana
Vagnozzi, Ariel Eduardo
Tomás, Gonzalo
Techera, Claudia
Gerez Miranda, Rocio Del Carmen
Hernández, Martín
Williman, Joaquín
Realpe, Mauricio
Greif, Gonzalo
Panzera, Yanina
Pérez, Ruben
author Marandino, Ana
author_facet Marandino, Ana
Vagnozzi, Ariel Eduardo
Tomás, Gonzalo
Techera, Claudia
Gerez Miranda, Rocio Del Carmen
Hernández, Martín
Williman, Joaquín
Realpe, Mauricio
Greif, Gonzalo
Panzera, Yanina
Pérez, Ruben
author_role author
author2 Vagnozzi, Ariel Eduardo
Tomás, Gonzalo
Techera, Claudia
Gerez Miranda, Rocio Del Carmen
Hernández, Martín
Williman, Joaquín
Realpe, Mauricio
Greif, Gonzalo
Panzera, Yanina
Pérez, Ruben
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bronchitis
Lineage
Recombination
Mutation
Avian Infectious Bronchitis Virus
South America
Bronquitis
Linaje
Recombinación
Mutación
Virus Bronquitis Infecciosa Aviar
América del Sur
topic Bronchitis
Lineage
Recombination
Mutation
Avian Infectious Bronchitis Virus
South America
Bronquitis
Linaje
Recombinación
Mutación
Virus Bronquitis Infecciosa Aviar
América del Sur
dc.description.none.fl_txt_mv The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America. GI-11 is endemic to South America, and the GI-16 is globally distributed. We obtained full-length IBV genomes from Argentine and Uruguayan farms using Illumina sequencing. Genomes of the GI-11 and GI-16 lineages from Argentina and Uruguay differ in part of the spike coding region. The remaining genome regions are similar to the Chinese and Italian strains of the GI-16 lineage that emerged in Asia or Europe in the 1970s. Our findings support that the indigenous GI-11 strains recombine extensively with the invasive GI-16 strains. During the recombination process, GI-11 acquired most of the sequences of the GI-16, retaining the original S1 sequence. GI-11 strains with recombinant genomes are circulating forms that underwent further local evolution. The current IBV scenario in South America includes the GI-16 lineage, recombinant GI-11 strains sharing high similarity with GI-16 outside S1, and Brazilian GI-11 strains with a divergent genomic background. There is also sporadic recombinant in the GI-11 and GI-16 lineages among vaccine and field strains. Our findings exemplified the ability of IBV to generate emergent lineage by using the S gene in different genomic backgrounds. This unique example of recombinational microevolution underscores the genomic plasticity of IBV in South America.
Instituto de Virología
Fil: Marandino, Ana. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Vagnozzi, Ariel Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Tomás, Gonzalo. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Techera, Claudia. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Gerez Miranda, Rocio Del Carmen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Hernández, Martín. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Williman, Joaquín. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Realpe, Mauricio. Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias; México
Fil: Greif, Gonzalo. Instituto Pasteur de Montevideo. Unidad de Biología Molecular; Uruguay
Fil: Panzera, Yanina. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Pérez, Ruben. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay
description The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America. GI-11 is endemic to South America, and the GI-16 is globally distributed. We obtained full-length IBV genomes from Argentine and Uruguayan farms using Illumina sequencing. Genomes of the GI-11 and GI-16 lineages from Argentina and Uruguay differ in part of the spike coding region. The remaining genome regions are similar to the Chinese and Italian strains of the GI-16 lineage that emerged in Asia or Europe in the 1970s. Our findings support that the indigenous GI-11 strains recombine extensively with the invasive GI-16 strains. During the recombination process, GI-11 acquired most of the sequences of the GI-16, retaining the original S1 sequence. GI-11 strains with recombinant genomes are circulating forms that underwent further local evolution. The current IBV scenario in South America includes the GI-16 lineage, recombinant GI-11 strains sharing high similarity with GI-16 outside S1, and Brazilian GI-11 strains with a divergent genomic background. There is also sporadic recombinant in the GI-11 and GI-16 lineages among vaccine and field strains. Our findings exemplified the ability of IBV to generate emergent lineage by using the S gene in different genomic backgrounds. This unique example of recombinational microevolution underscores the genomic plasticity of IBV in South America.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
2023-12-27T14:38:15Z
2023-12-27T14:38:15Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/16368
https://www.mdpi.com/1999-4915/14/10/2095
1999-4915
https://doi.org/10.3390/v14102095
url http://hdl.handle.net/20.500.12123/16368
https://www.mdpi.com/1999-4915/14/10/2095
https://doi.org/10.3390/v14102095
identifier_str_mv 1999-4915
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Viruses 14 (10) : 2095 (Octubre 2022)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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