Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine

Autores
Caballero García, Melanie; Mendoza Espinoza, Alfredo; Ascanio, Silvia; Chero, Paula; Rojas, Rober; Huberman, Yosef Daniel
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Worldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, generally, without any information regarding their virulence. The characterization of the pathogenicity of 24 Av. paragallinarum strains of the three Page serogroups, including four variant strains of serogroup B, all isolated from infectious coryza outbreaks in Peru, was performed. After experimental inoculation into the infraorbital sinuses, information regarding their capacity to induce infectious coryza typical clinical signs, spreading, and colonization was recorded. Furthermore, after intraperitoneal inoculation, septicaemia and death were registered. Differences among strains in these parameters were observed, even within strains from the same serogroup. Finally, the four most pathogenic strains, one from each serogroup, were chosen to formulate an experimental vaccine that was tested successfully against homologous challenges in reducing clinical signs and colonization in vaccinated birds compared to unvaccinated ones. This is the first time that Av. paragallinarum strains from Peru were studied thoroughly for their virulence in a search for improving vaccine formulation.
EEA Balcarce
Fil: Caballero Garcia, Melanie. Quimtia. Research and Development; Perú.
Fil: Mendoza Espinoza, Alfredo. Quimtia. Research and Development; Perú.
Fil: Ascanio, Silvia. Quimtia. Research and Development; Perú.
Fil: Chero, Paula. Quimtia. Research and Development; Perú.
Fil: Rojas, Rober. Quimtia. Research and Development; Perú.
Fil: Huberman, Yosef Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fuente
Vaccines 10 (7) : 1043 (July 2022)
Materia
Aves de Corral
Coriza
Patogenicidad
Vacuna Inactivada
Poultry
Coryza
Pathogenicity
Inactivated Vaccines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/12506
Acceder
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oai_identifier_str oai:localhost:20.500.12123/12506
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network_name_str INTA Digital (INTA)
spelling Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccineCaballero García, MelanieMendoza Espinoza, AlfredoAscanio, SilviaChero, PaulaRojas, RoberHuberman, Yosef DanielAves de CorralCorizaPatogenicidadVacuna InactivadaPoultryCoryzaPathogenicityInactivated VaccinesWorldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, generally, without any information regarding their virulence. The characterization of the pathogenicity of 24 Av. paragallinarum strains of the three Page serogroups, including four variant strains of serogroup B, all isolated from infectious coryza outbreaks in Peru, was performed. After experimental inoculation into the infraorbital sinuses, information regarding their capacity to induce infectious coryza typical clinical signs, spreading, and colonization was recorded. Furthermore, after intraperitoneal inoculation, septicaemia and death were registered. Differences among strains in these parameters were observed, even within strains from the same serogroup. Finally, the four most pathogenic strains, one from each serogroup, were chosen to formulate an experimental vaccine that was tested successfully against homologous challenges in reducing clinical signs and colonization in vaccinated birds compared to unvaccinated ones. This is the first time that Av. paragallinarum strains from Peru were studied thoroughly for their virulence in a search for improving vaccine formulation.EEA BalcarceFil: Caballero Garcia, Melanie. Quimtia. Research and Development; Perú.Fil: Mendoza Espinoza, Alfredo. Quimtia. Research and Development; Perú.Fil: Ascanio, Silvia. Quimtia. Research and Development; Perú.Fil: Chero, Paula. Quimtia. Research and Development; Perú.Fil: Rojas, Rober. Quimtia. Research and Development; Perú.Fil: Huberman, Yosef Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.MDPI2022-08-05T11:28:46Z2022-08-05T11:28:46Z2022-06-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/12506https://www.mdpi.com/2076-393X/10/7/10432076-393Xhttps://doi.org/10.3390/vaccines10071043Vaccines 10 (7) : 1043 (July 2022)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:49:30Zoai:localhost:20.500.12123/12506instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:49:31.072INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
title Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
spellingShingle Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
Caballero García, Melanie
Aves de Corral
Coriza
Patogenicidad
Vacuna Inactivada
Poultry
Coryza
Pathogenicity
Inactivated Vaccines
title_short Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
title_full Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
title_fullStr Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
title_full_unstemmed Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
title_sort Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
dc.creator.none.fl_str_mv Caballero García, Melanie
Mendoza Espinoza, Alfredo
Ascanio, Silvia
Chero, Paula
Rojas, Rober
Huberman, Yosef Daniel
author Caballero García, Melanie
author_facet Caballero García, Melanie
Mendoza Espinoza, Alfredo
Ascanio, Silvia
Chero, Paula
Rojas, Rober
Huberman, Yosef Daniel
author_role author
author2 Mendoza Espinoza, Alfredo
Ascanio, Silvia
Chero, Paula
Rojas, Rober
Huberman, Yosef Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Aves de Corral
Coriza
Patogenicidad
Vacuna Inactivada
Poultry
Coryza
Pathogenicity
Inactivated Vaccines
topic Aves de Corral
Coriza
Patogenicidad
Vacuna Inactivada
Poultry
Coryza
Pathogenicity
Inactivated Vaccines
dc.description.none.fl_txt_mv Worldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, generally, without any information regarding their virulence. The characterization of the pathogenicity of 24 Av. paragallinarum strains of the three Page serogroups, including four variant strains of serogroup B, all isolated from infectious coryza outbreaks in Peru, was performed. After experimental inoculation into the infraorbital sinuses, information regarding their capacity to induce infectious coryza typical clinical signs, spreading, and colonization was recorded. Furthermore, after intraperitoneal inoculation, septicaemia and death were registered. Differences among strains in these parameters were observed, even within strains from the same serogroup. Finally, the four most pathogenic strains, one from each serogroup, were chosen to formulate an experimental vaccine that was tested successfully against homologous challenges in reducing clinical signs and colonization in vaccinated birds compared to unvaccinated ones. This is the first time that Av. paragallinarum strains from Peru were studied thoroughly for their virulence in a search for improving vaccine formulation.
EEA Balcarce
Fil: Caballero Garcia, Melanie. Quimtia. Research and Development; Perú.
Fil: Mendoza Espinoza, Alfredo. Quimtia. Research and Development; Perú.
Fil: Ascanio, Silvia. Quimtia. Research and Development; Perú.
Fil: Chero, Paula. Quimtia. Research and Development; Perú.
Fil: Rojas, Rober. Quimtia. Research and Development; Perú.
Fil: Huberman, Yosef Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
description Worldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, generally, without any information regarding their virulence. The characterization of the pathogenicity of 24 Av. paragallinarum strains of the three Page serogroups, including four variant strains of serogroup B, all isolated from infectious coryza outbreaks in Peru, was performed. After experimental inoculation into the infraorbital sinuses, information regarding their capacity to induce infectious coryza typical clinical signs, spreading, and colonization was recorded. Furthermore, after intraperitoneal inoculation, septicaemia and death were registered. Differences among strains in these parameters were observed, even within strains from the same serogroup. Finally, the four most pathogenic strains, one from each serogroup, were chosen to formulate an experimental vaccine that was tested successfully against homologous challenges in reducing clinical signs and colonization in vaccinated birds compared to unvaccinated ones. This is the first time that Av. paragallinarum strains from Peru were studied thoroughly for their virulence in a search for improving vaccine formulation.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-05T11:28:46Z
2022-08-05T11:28:46Z
2022-06-29
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/12506
https://www.mdpi.com/2076-393X/10/7/1043
2076-393X
https://doi.org/10.3390/vaccines10071043
url http://hdl.handle.net/20.500.12123/12506
https://www.mdpi.com/2076-393X/10/7/1043
https://doi.org/10.3390/vaccines10071043
identifier_str_mv 2076-393X
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Vaccines 10 (7) : 1043 (July 2022)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1842341399092002816
score 12.623145

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