In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves

Autores
Hugo, Ayelén A.; Serradell, María De los Ángeles; Peri, Pablo Luis; Farina, Sebastián; Gomez-Zavaglia, Andrea
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress.
EEA Santa Cruz
Fil: Hugo, Ayelén A. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina.
Fil: Serradell, María De los Ángeles. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Microbiología; Argentina.
Fil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; Argentina.
Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Peri, Pablo Luis. Universidad Nacional de la Patagonia Austral; Argentina.
Fil: Farina, Sebastián. Gobierno de Tierra del Fuego, Antártida e Islas del Atlántico Sur. Ministerio de Producción y Ambiente. Secretaría de Desarrollo Productivo y PyME. Dirección General de Desarrollo Forestal; Argentina.
Fil: Gomez-Zavaglia, Andrea. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina.
Fuente
CyTA-Journal of Food 22 (1) : e2298569. (January 2024)
Materia
Nothofagus
Bosques Primarios
Uso Múltiple
Hojas
Infusión
Propiedades Antioxidantes
Toxicidad
Ratones
Polifenoles
Flavonoides
Ensayos de Toxicidad
Histopatología
Primary Forests
Multiple Use
Leaves
Infusion
Antioxidant Properties
Toxicity
Mice
Polyphenols
Flavonoids
Toxicity Tests
Histopathology
Antioxidant Activity
Animal Model
Biological Samples
Plasma Biochemistry
Antioxidant Capacity
Actividad Antioxidante
Ñire
Nothofagus antarctica
Modelo Animal
Muestras Biológicas
Bioquímica Plasmática
Capacidad Antioxidante
Región Patagónica
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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network_name_str INTA Digital (INTA)
spelling In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leavesHugo, Ayelén A.Serradell, María De los ÁngelesPeri, Pablo LuisFarina, SebastiánGomez-Zavaglia, AndreaNothofagusBosques PrimariosUso MúltipleHojasInfusiónPropiedades AntioxidantesToxicidadRatonesPolifenolesFlavonoidesEnsayos de ToxicidadHistopatologíaPrimary ForestsMultiple UseLeavesInfusionAntioxidant PropertiesToxicityMicePolyphenolsFlavonoidsToxicity TestsHistopathologyAntioxidant ActivityAnimal ModelBiological SamplesPlasma BiochemistryAntioxidant CapacityActividad AntioxidanteÑireNothofagus antarcticaModelo AnimalMuestras BiológicasBioquímica PlasmáticaCapacidad AntioxidanteRegión PatagónicaNothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress.EEA Santa CruzFil: Hugo, Ayelén A. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina.Fil: Serradell, María De los Ángeles. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Microbiología; Argentina.Fil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; Argentina.Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Peri, Pablo Luis. Universidad Nacional de la Patagonia Austral; Argentina.Fil: Farina, Sebastián. Gobierno de Tierra del Fuego, Antártida e Islas del Atlántico Sur. Ministerio de Producción y Ambiente. Secretaría de Desarrollo Productivo y PyME. Dirección General de Desarrollo Forestal; Argentina.Fil: Gomez-Zavaglia, Andrea. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina.Taylor & Francis Group2024-02-28T11:49:16Z2024-02-28T11:49:16Z2024-01-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/16818https://www.tandfonline.com/doi/full/10.1080/19476337.2023.2298569Hugo A.A.; Serradell M.A.; Peri P.L.; Farina S.; Gómez-Zavaglia A. (2024) In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves. CyTA-Journal of Food 22(1): e2298569. https://doi.org/10.1080/19476337.2023.22985691947-6345 (Online)1947-6337 (print)https://doi.org/10.1080/19476337.2023.2298569CyTA-Journal of Food 22 (1) : e2298569. (January 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:31:30Zoai:localhost:20.500.12123/16818instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:31:30.541INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
spellingShingle In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
Hugo, Ayelén A.
Nothofagus
Bosques Primarios
Uso Múltiple
Hojas
Infusión
Propiedades Antioxidantes
Toxicidad
Ratones
Polifenoles
Flavonoides
Ensayos de Toxicidad
Histopatología
Primary Forests
Multiple Use
Leaves
Infusion
Antioxidant Properties
Toxicity
Mice
Polyphenols
Flavonoids
Toxicity Tests
Histopathology
Antioxidant Activity
Animal Model
Biological Samples
Plasma Biochemistry
Antioxidant Capacity
Actividad Antioxidante
Ñire
Nothofagus antarctica
Modelo Animal
Muestras Biológicas
Bioquímica Plasmática
Capacidad Antioxidante
Región Patagónica
title_short In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_full In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_fullStr In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_full_unstemmed In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_sort In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
dc.creator.none.fl_str_mv Hugo, Ayelén A.
Serradell, María De los Ángeles
Peri, Pablo Luis
Farina, Sebastián
Gomez-Zavaglia, Andrea
author Hugo, Ayelén A.
author_facet Hugo, Ayelén A.
Serradell, María De los Ángeles
Peri, Pablo Luis
Farina, Sebastián
Gomez-Zavaglia, Andrea
author_role author
author2 Serradell, María De los Ángeles
Peri, Pablo Luis
Farina, Sebastián
Gomez-Zavaglia, Andrea
author2_role author
author
author
author
dc.subject.none.fl_str_mv Nothofagus
Bosques Primarios
Uso Múltiple
Hojas
Infusión
Propiedades Antioxidantes
Toxicidad
Ratones
Polifenoles
Flavonoides
Ensayos de Toxicidad
Histopatología
Primary Forests
Multiple Use
Leaves
Infusion
Antioxidant Properties
Toxicity
Mice
Polyphenols
Flavonoids
Toxicity Tests
Histopathology
Antioxidant Activity
Animal Model
Biological Samples
Plasma Biochemistry
Antioxidant Capacity
Actividad Antioxidante
Ñire
Nothofagus antarctica
Modelo Animal
Muestras Biológicas
Bioquímica Plasmática
Capacidad Antioxidante
Región Patagónica
topic Nothofagus
Bosques Primarios
Uso Múltiple
Hojas
Infusión
Propiedades Antioxidantes
Toxicidad
Ratones
Polifenoles
Flavonoides
Ensayos de Toxicidad
Histopatología
Primary Forests
Multiple Use
Leaves
Infusion
Antioxidant Properties
Toxicity
Mice
Polyphenols
Flavonoids
Toxicity Tests
Histopathology
Antioxidant Activity
Animal Model
Biological Samples
Plasma Biochemistry
Antioxidant Capacity
Actividad Antioxidante
Ñire
Nothofagus antarctica
Modelo Animal
Muestras Biológicas
Bioquímica Plasmática
Capacidad Antioxidante
Región Patagónica
dc.description.none.fl_txt_mv Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress.
EEA Santa Cruz
Fil: Hugo, Ayelén A. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina.
Fil: Serradell, María De los Ángeles. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Microbiología; Argentina.
Fil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; Argentina.
Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Peri, Pablo Luis. Universidad Nacional de la Patagonia Austral; Argentina.
Fil: Farina, Sebastián. Gobierno de Tierra del Fuego, Antártida e Islas del Atlántico Sur. Ministerio de Producción y Ambiente. Secretaría de Desarrollo Productivo y PyME. Dirección General de Desarrollo Forestal; Argentina.
Fil: Gomez-Zavaglia, Andrea. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina.
description Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-28T11:49:16Z
2024-02-28T11:49:16Z
2024-01-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/16818
https://www.tandfonline.com/doi/full/10.1080/19476337.2023.2298569
Hugo A.A.; Serradell M.A.; Peri P.L.; Farina S.; Gómez-Zavaglia A. (2024) In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves. CyTA-Journal of Food 22(1): e2298569. https://doi.org/10.1080/19476337.2023.2298569
1947-6345 (Online)
1947-6337 (print)
https://doi.org/10.1080/19476337.2023.2298569
url http://hdl.handle.net/20.500.12123/16818
https://www.tandfonline.com/doi/full/10.1080/19476337.2023.2298569
https://doi.org/10.1080/19476337.2023.2298569
identifier_str_mv Hugo A.A.; Serradell M.A.; Peri P.L.; Farina S.; Gómez-Zavaglia A. (2024) In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves. CyTA-Journal of Food 22(1): e2298569. https://doi.org/10.1080/19476337.2023.2298569
1947-6345 (Online)
1947-6337 (print)
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Group
publisher.none.fl_str_mv Taylor & Francis Group
dc.source.none.fl_str_mv CyTA-Journal of Food 22 (1) : e2298569. (January 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.712165

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