Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins

Autores
Zampini, Iris Catiana; Isla, Maria Ines; Schmeda Hirschmann, Guillermo
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of "tola", Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionation of the polar extracts was carried out using the ABTS + autographic as well as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis bioautographic test. Seven compounds were isolated from the polar extracts and identifed as chlorogenic acid, 3',4',5,7-tetrahydroxyfavone; dicaffeoyl quinic acid; 3',4',5,7-tetrahydroxy-3,6-dimethoxyfavone; 3',4',5,7-tetrahydroxy-3,6,8-trimethoxy favone, 4',5,7-trihydroxy-3',3,6,8-tetramethoxyfavone and 4',5-dihydroxy-3',3,6,7,8-pentamethoxyfavone. The main constituents from the methanol extract and infusion were caffeic acid derivatives. This is the frst report on the constituents of B. incarum infusion and show clear differences with previous phytochemical studies on the same plant. All isolated compounds showed antioxidant activity with SC50 values of 1 to 10 µg/ml. The isolated favones were active against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis with MICs in the range 100 and >200 µg/ml.
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Schmeda Hirschmann, Guillermo. Universidad de Talca; Chile
Materia
Baccharis Incarum
Asteraceae
Infusion
Hplc-Ms
Polyphenols
Antimicrobial Activity
Antioxidant
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/45689
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/45689
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) PerkinsZampini, Iris CatianaIsla, Maria InesSchmeda Hirschmann, GuillermoBaccharis IncarumAsteraceaeInfusionHplc-MsPolyphenolsAntimicrobial ActivityAntioxidanthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of "tola", Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionation of the polar extracts was carried out using the ABTS + autographic as well as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis bioautographic test. Seven compounds were isolated from the polar extracts and identifed as chlorogenic acid, 3',4',5,7-tetrahydroxyfavone; dicaffeoyl quinic acid; 3',4',5,7-tetrahydroxy-3,6-dimethoxyfavone; 3',4',5,7-tetrahydroxy-3,6,8-trimethoxy favone, 4',5,7-trihydroxy-3',3,6,8-tetramethoxyfavone and 4',5-dihydroxy-3',3,6,7,8-pentamethoxyfavone. The main constituents from the methanol extract and infusion were caffeic acid derivatives. This is the frst report on the constituents of B. incarum infusion and show clear differences with previous phytochemical studies on the same plant. All isolated compounds showed antioxidant activity with SC50 values of 1 to 10 µg/ml. The isolated favones were active against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis with MICs in the range 100 and >200 µg/ml.Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Schmeda Hirschmann, Guillermo. Universidad de Talca; ChileSociedad Chilena de Química2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/45689Zampini, Iris Catiana; Isla, Maria Ines; Schmeda Hirschmann, Guillermo; Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins; Sociedad Chilena de Química; Journal of the Chilean Chemical Society; 54; 4; 12-2009; 289-2930717-93240717-9707CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400035info:eu-repo/semantics/altIdentifier/doi/10.4067/S0717-97072009000400035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:21Zoai:ri.conicet.gov.ar:11336/45689instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:21.307CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
title Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
spellingShingle Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
Zampini, Iris Catiana
Baccharis Incarum
Asteraceae
Infusion
Hplc-Ms
Polyphenols
Antimicrobial Activity
Antioxidant
title_short Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
title_full Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
title_fullStr Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
title_full_unstemmed Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
title_sort Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
dc.creator.none.fl_str_mv Zampini, Iris Catiana
Isla, Maria Ines
Schmeda Hirschmann, Guillermo
author Zampini, Iris Catiana
author_facet Zampini, Iris Catiana
Isla, Maria Ines
Schmeda Hirschmann, Guillermo
author_role author
author2 Isla, Maria Ines
Schmeda Hirschmann, Guillermo
author2_role author
author
dc.subject.none.fl_str_mv Baccharis Incarum
Asteraceae
Infusion
Hplc-Ms
Polyphenols
Antimicrobial Activity
Antioxidant
topic Baccharis Incarum
Asteraceae
Infusion
Hplc-Ms
Polyphenols
Antimicrobial Activity
Antioxidant
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of "tola", Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionation of the polar extracts was carried out using the ABTS + autographic as well as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis bioautographic test. Seven compounds were isolated from the polar extracts and identifed as chlorogenic acid, 3',4',5,7-tetrahydroxyfavone; dicaffeoyl quinic acid; 3',4',5,7-tetrahydroxy-3,6-dimethoxyfavone; 3',4',5,7-tetrahydroxy-3,6,8-trimethoxy favone, 4',5,7-trihydroxy-3',3,6,8-tetramethoxyfavone and 4',5-dihydroxy-3',3,6,7,8-pentamethoxyfavone. The main constituents from the methanol extract and infusion were caffeic acid derivatives. This is the frst report on the constituents of B. incarum infusion and show clear differences with previous phytochemical studies on the same plant. All isolated compounds showed antioxidant activity with SC50 values of 1 to 10 µg/ml. The isolated favones were active against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis with MICs in the range 100 and >200 µg/ml.
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Schmeda Hirschmann, Guillermo. Universidad de Talca; Chile
description In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of "tola", Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionation of the polar extracts was carried out using the ABTS + autographic as well as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis bioautographic test. Seven compounds were isolated from the polar extracts and identifed as chlorogenic acid, 3',4',5,7-tetrahydroxyfavone; dicaffeoyl quinic acid; 3',4',5,7-tetrahydroxy-3,6-dimethoxyfavone; 3',4',5,7-tetrahydroxy-3,6,8-trimethoxy favone, 4',5,7-trihydroxy-3',3,6,8-tetramethoxyfavone and 4',5-dihydroxy-3',3,6,7,8-pentamethoxyfavone. The main constituents from the methanol extract and infusion were caffeic acid derivatives. This is the frst report on the constituents of B. incarum infusion and show clear differences with previous phytochemical studies on the same plant. All isolated compounds showed antioxidant activity with SC50 values of 1 to 10 µg/ml. The isolated favones were active against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis with MICs in the range 100 and >200 µg/ml.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/45689
Zampini, Iris Catiana; Isla, Maria Ines; Schmeda Hirschmann, Guillermo; Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins; Sociedad Chilena de Química; Journal of the Chilean Chemical Society; 54; 4; 12-2009; 289-293
0717-9324
0717-9707
CONICET Digital
CONICET
url http://hdl.handle.net/11336/45689
identifier_str_mv Zampini, Iris Catiana; Isla, Maria Ines; Schmeda Hirschmann, Guillermo; Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins; Sociedad Chilena de Química; Journal of the Chilean Chemical Society; 54; 4; 12-2009; 289-293
0717-9324
0717-9707
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400035
info:eu-repo/semantics/altIdentifier/doi/10.4067/S0717-97072009000400035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Chilena de Química
publisher.none.fl_str_mv Sociedad Chilena de Química
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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